BMS986260
BMS-986260
CAS: 2001559-19-7
Molecular Formula: C18H12ClFN6O
BMS986260 - Names and Identifiers
| Name | BMS-986260 |
| Synonyms | BMS986260 BMS-986260 6-(4-(3-Chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidazol-5-yl)imidazo[1,2-b]pyridazine-3-carbonitrile |
| CAS | 2001559-19-7 |
BMS986260 - Physico-chemical Properties
| Molecular Formula | C18H12ClFN6O |
| Molar Mass | 382.78 |
| Solubility | Soluble in DMSO |
| Storage Condition | -20℃ |
| Use | BMS-986260 is a potent, selective, and orally bioavailable TGFβR1 inhibitor (IC50=1.6 nM). BMS-986260 demonstrated functional activity in multiple TGFβ- dependent cellular assays, excellent kinome selectivity, favorable pharmacokinetic properties, and curative in vivo efficacy in combination with anti-PD-1 antibody in murine colorectal cancer (CRC) models。 |
BMS986260 - Reference
| Reference Show more | Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology AgentUpender Velaparthi*Chetan Padmakar DarneJayakumar WarrierPeiying LiuHasibur RahamanKaren Augustine-RauchKaren ParrishZheng YangJesse SwansonJennifer BrownGopal DharAravind AnandamVinay K. HolenarsipurKamalavenkatesh PalanisamyBarri S. WautletMark P. FereshtehJonathan LippyAndrew J. TebbenSteven SheriffMax RuzanovChunhong YanAnuradha GuptaArun Kumar GuptaMuthalagu VetrichelvanArvind MathurMarina GelmanRajinder SinghTodd KinsellaAnwar MurtazaJoseph FargnoliGregory ViteRobert M. BorzilleriACS Medicinal Chemistry Letters, Articles ASAP (Letter)Subscribed AccessPublication Date (Web):January 28, 2020。 |
BMS986260 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.612 ml | 13.062 ml | 26.124 ml |
| 5 mM | 0.522 ml | 2.612 ml | 5.225 ml |
| 10 mM | 0.261 ml | 1.306 ml | 2.612 ml |
| 5 mM | 0.052 ml | 0.261 ml | 0.522 ml |
Last Update：2024-01-02 23:10:35
