BOC-D-SER(BZL)-OH

BOC-D-SER(BZL)-OH - Names and Identifiers

Name	N-Boc-O-benzyl-D-serine
Synonyms	Boc-D-Ser(Bzl) Boc-D-Ser(Bzl)-OH BOC-D-SER(BZL)-OH Boc-DL-Ser(Bzl)-OH BOC-D-SERINE(BZL)-OH N-Boc-O-benzyl-D-serine O-Benzyl-N-(tert-butoxycarbonyl)-D-serine (2R)-3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]propanoate L-Serine, N-((1,1-dimethylethoxy)carbonyl)-O-(phenylmethyl)- D-serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- (2R)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propionic acid (2R)-2-(tert-butoxycarbonylamino)-3-(phenylmethoxy)propanoic acid (2R)-2-[(tert-butoxy-oxomethyl)amino]-3-(phenylmethoxy)propanoic acid (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(phenylmethoxy)propanoic acid
CAS	47173-80-8
EINECS	827-299-8
InChI	InChI=1/C15H21NO5/c1-15(2,3)21-14(19)16-12(13(17)18)10-20-9-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,16,19)(H,17,18)/p-1/t12-/m1/s1
InChIKey	DMBKPDOAQVGTST-GFCCVEGCSA-N

BOC-D-SER(BZL)-OH - Physico-chemical Properties

Molecular Formula	C15H21NO5
Molar Mass	295.33
Density	1.1454 (rough estimate)
Melting Point	58-60°C(lit.)
Boling Point	437.02°C (rough estimate)
Specific Rotation(α)	-19 º (c=2 80% alcohol)
Flash Point	229.7°C
Solubility	almost transparency in Methanol
Vapor Presure	4.07E-09mmHg at 25°C
Appearance	Powder
Color	White
BRN	2665080
pKa	3.53±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	-20 ° (C=2, 80% EtOH

BOC-D-SER(BZL)-OH - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
HS Code	2924 29 70
Hazard Class	IRRITANT

BOC-D-SER(BZL)-OH - Introduction

N-Boc-O-benzyl-D-serine is a compound that has the following properties:

1. Appearance: colorless to yellowish solid.
2. Solubility: Soluble in some organic solvents, such as dimethylformamide (DMF) and dichloromethane.
3. Stability: Stable under dry conditions, but hydrolysis may occur in a humid environment.

One of the main uses of N-Boc-O-benzyl-D-serine is as an intermediate in organic synthesis. It is commonly used in the synthesis of biologically active natural products or drugs, and can be subsequently modified by other reactions.

The preparation of N-Boc-O-benzyl-D-serine can be carried out by the following steps:

1. Benzyl-serine reacts with di-tert-butyldimethylsilyl (Boc) chloride to generate N-Boc-benzyl-serine.
2. This intermediate can be further reacted with benzyl alcohol in dichloromethane to give N-Boc-O-benzyl-D-serine.

Pay attention to safety information when using N-Boc-O-benzyl-D-serine, prevent contact with skin and eyes, and avoid inhalation or intake. At the same time, sealed storage can prolong the stability of the compound.

Last Update：2024-04-09 21:11:58