BOC-L-ORN(BOC) - Names and Identifiers
Name | Boc-Orn(Boc)-OH
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Synonyms | BOC-L-ORN(BOC) BOC-ORN(BOC)-OH Boc-Orn(Boc)-OH BOC-L-ORN(BOC)-OH N,N'-Bis-Boc-L-ornithine N-ALPHA,DELTA-BIS-BOC-L-ORNITHINE N,N'-DI-(T-BUTYLOXYCARBONYL)-L-ORNITHINE N,N'-DI-(TERT-BUTYLOXYCARBONYL)-L-ORNITHINE N~2~,N~5~-bis(tert-butoxycarbonyl)-D-ornithine N-ALPHA,N-DELTA-DI-T-BUTOXYCARBONYL-L-ORNITHINE (2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentanoate (S)-2,5-Bis((tert-butoxycarbonyl)amino)pentanoic acid
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CAS | 57133-29-6
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InChI | InChI=1/C15H28N2O6/c1-14(2,3)22-12(20)16-9-7-8-10(11(18)19)17-13(21)23-15(4,5)6/h10H,7-9H2,1-6H3,(H,16,20)(H,17,21)(H,18,19)/p-1/t10-/m0/s1 |
BOC-L-ORN(BOC) - Physico-chemical Properties
Molecular Formula | C15H28N2O6
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Molar Mass | 332.39 |
Density | 1.123±0.06 g/cm3(Predicted) |
Boling Point | 504.1±45.0 °C(Predicted) |
Flash Point | 258.7°C |
Vapor Presure | 1.58E-11mmHg at 25°C |
pKa | 3.96±0.21(Predicted) |
Storage Condition | Sealed in dry,2-8°C |
BOC-L-ORN(BOC) - Introduction
(2S)-2,5-bis [(tert-butoxycarbonyl) amino] pentanoic acid (Boc-Orn(Boc)-OH) is an organic compound. The following is a detailed description of its nature, use, formulation and safety information:
Nature:
-Appearance: colorless crystal or white solid
-Solubility: Soluble in common organic solvents such as dimethyl sulfoxide (DMSO), methanol and ethanol
-Melting point: about 125-129°C (decomposition)
-Molecular formula: C18H35N3O6
-Molecular weight: 397.49
- CAS No.: 101027-56-6
Use:
Boc-Orn(Boc)-OH is a reagent commonly used in biochemistry and organic synthesis. The main uses include:
-Peptide and protein synthesis: as a protected amino acid based on solid phase synthesis for the synthesis of polypeptide chains
-Drug synthesis: for the synthesis of amino acid derivatives and peptide compounds, especially for the synthesis of antiviral and anticancer drugs
-Biological research: used as substrates or reaction intermediates in cell signaling, enzyme inhibitors and protein structure research
Preparation Method:
Boc-Orn(Boc)-OH can be prepared by the following steps:
1. Preparation of Boc-protecting group: reacting t-Boc (tert-butoxycarbonyl) chloroformate with tert-butyl diamine under acidic conditions to generate Boc-protecting group
2. introduction of tert-butoxycarbonyl protecting group: reacting Boc-protecting group with malic anhydride (Gould reagent) to introduce tert-butoxycarbonyl protecting group
3. Synthesis of Boc-Orn(Boc)-OH: The Boc-protecting group introduced into the tert-butoxycarbonyl protecting group reacts with L-ornithine (Orn(OH)) to generate the Boc-Orn(Boc)-OH product
Safety Information:
Boc-Orn(Boc)-OH is an organic compound. Pay attention to the following safety precautions when using it:
-Avoid inhalation, contact with skin and eyes, avoid ingestion
-Experiment should be operated in a well-ventilated environment, wear protective gloves and protective glasses
-In case of contact, rinse immediately with plenty of water and seek medical help if necessary
-waste disposal, follow the relevant provisions, not free discharge or dumping
Last Update:2024-04-09 15:17:58