BOC-PHG(4-CN)-(C*CH2)OH
Boc-(R)-3-Amino-3-(4-Cyano phenyl)-propionic acid
CAS:
Molecular Formula: C15H18N2O4
BOC-PHG(4-CN)-(C*CH2)OH - Names and Identifiers
BOC-PHG(4-CN)-(C*CH2)OH - Physico-chemical Properties
| Molecular Formula | C15H18N2O4 |
| Molar Mass | 290.31 |
BOC-PHG(4-CN)-(C*CH2)OH - Risk and Safety
| WGK Germany | 3 |
BOC-PHG(4-CN)-(C*CH2)OH - Introduction
Boc-(R)-3-Amino-3-(4-Cyano phenyl)-propionic acid, also known as Boc-(R)-3-Amino-3-(4-Cyano phenyl)-propionic acid, is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
1. Appearance: usually white to light yellow crystalline solid;
2. molecular formula: C16H18N2O4;
3. Molecular weight: 302.33g/mol;
4. melting point: about 110-115 degrees Celsius;
5. Solubility: It has good solubility in common organic solvents such as methanol and dimethylformamide.
Use:
1. Boc-(R)-3-Amino-3-(4-Cyano phenyl)-propionic acid is an important organic synthesis intermediate, which is commonly used in pharmaceutical and medical fields for the synthesis of various bioactive molecules;
2. In the synthesis of amine compounds, Boc-(R)-3-Amino-3-(4-Cyano phenyl)-propionic acid can be used as a protecting group to protect amine groups;
3. can also be used for the synthesis of organic compounds with special functions.
Preparation Method:
The preparation of Boc-(R)-3-Amino-3-(4-Cyano phenyl)-propionic acid can usually be accomplished by the following steps:
1. Using acetone as solvent, 4-cyanophenylacetic acid and isobutyraldehyde were Knoevenagel condensed to synthesize barfenketone;
2. The Grignard reagent reaction of barfenone and ethyl tranexamate generates Boc-locked-Boc-(R)-3-amino -3-(4-cyanophenyl) propionate;
3. hydrolyze the product under appropriate conditions to remove the Boc protecting group to obtain Boc-(R)-3-Amino-3-(4-Cyano phenyl)-propionic acid.
Safety Information:
1. Boc-(R)-3-Amino-3-(4-Cyano phenyl)-propionic acid is an organic synthetic intermediate, which may have certain irritation. Prolonged exposure to skin, eyes and environment should be avoided;
2. in use and handling, should take appropriate safety measures, such as wearing chemical protective gloves, glasses and respiratory protective equipment;
3. should be stored in a dry, cool place, avoid contact with oxidants and strong acid.
Nature:
1. Appearance: usually white to light yellow crystalline solid;
2. molecular formula: C16H18N2O4;
3. Molecular weight: 302.33g/mol;
4. melting point: about 110-115 degrees Celsius;
5. Solubility: It has good solubility in common organic solvents such as methanol and dimethylformamide.
Use:
1. Boc-(R)-3-Amino-3-(4-Cyano phenyl)-propionic acid is an important organic synthesis intermediate, which is commonly used in pharmaceutical and medical fields for the synthesis of various bioactive molecules;
2. In the synthesis of amine compounds, Boc-(R)-3-Amino-3-(4-Cyano phenyl)-propionic acid can be used as a protecting group to protect amine groups;
3. can also be used for the synthesis of organic compounds with special functions.
Preparation Method:
The preparation of Boc-(R)-3-Amino-3-(4-Cyano phenyl)-propionic acid can usually be accomplished by the following steps:
1. Using acetone as solvent, 4-cyanophenylacetic acid and isobutyraldehyde were Knoevenagel condensed to synthesize barfenketone;
2. The Grignard reagent reaction of barfenone and ethyl tranexamate generates Boc-locked-Boc-(R)-3-amino -3-(4-cyanophenyl) propionate;
3. hydrolyze the product under appropriate conditions to remove the Boc protecting group to obtain Boc-(R)-3-Amino-3-(4-Cyano phenyl)-propionic acid.
Safety Information:
1. Boc-(R)-3-Amino-3-(4-Cyano phenyl)-propionic acid is an organic synthetic intermediate, which may have certain irritation. Prolonged exposure to skin, eyes and environment should be avoided;
2. in use and handling, should take appropriate safety measures, such as wearing chemical protective gloves, glasses and respiratory protective equipment;
3. should be stored in a dry, cool place, avoid contact with oxidants and strong acid.
Last Update：2024-04-09 02:00:49
