BOHEMINE
BOHEMINE
CAS: 189232-42-6
Molecular Formula: C18H24N6O
BOHEMINE - Names and Identifiers
BOHEMINE - Physico-chemical Properties
| Molecular Formula | C18H24N6O |
| Molar Mass | 340.42 |
| Density | 1.27±0.1 g/cm3(Predicted) |
| Melting Point | 101-103 °C |
| Boling Point | 589.4±60.0 °C(Predicted) |
| Solubility | chloroform: 50mg/mL, soluble |
| Appearance | powder |
| pKa | 14.94±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
BOHEMINE - Risk and Safety
| WGK Germany | 3 |
BOHEMINE - Reference Information
| biological activity | Bohemine is a CDK inhibitor, the IC50 values for Cdk2/cyclin A and Cdk9/cyclin T1 were 4.6, 83 and 2.7 μm, respectively. |
| Target | Value |
| Cdk9/cyclin T1 () | 2.7 μM |
| Cdk2/cyclin E () | 4.6 μM |
| Cdk2/cyclin A () | 83 μM |
| Cell Line: | Mouse hybridoma ME-750 cells |
| Concentration: | 0 µM, 1 µM, 3 µM, 10 µM and 30 µM |
| Incubation Time: | 72 hours |
| Result: | At 10 µM and 30 µM concentrations, the viable cell count was significantly lower with respect to control, i.e., 77% and 48%, respectively. C max is 72,308 nM, observed clearance is 0.23 L/h and T 1/2 is 1.39 h. |
| Animal Model: | BALB/c mice bearing the colon 26 murine tumor |
| Dosage: | 50 mg/kg |
| Administration: | Intravenous injection (Pharmacokinetic Analysis) |
Last Update：2024-04-10 22:29:15
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Product Name: BOHEMINE Visit Supplier Webpage Request for quotationCAS: 189232-42-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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