BRD-9539
BRD9539
CAS: 1374601-41-8
Molecular Formula: C24H21N3O3
BRD-9539 - Names and Identifiers
BRD-9539 - Physico-chemical Properties
| Molecular Formula | C24H21N3O3 |
| Molar Mass | 399.44 |
| Solubility | DMSO: 10 mg/mL |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | 2-8°C |
| Use | BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 µM. |
| Target | G9a;PRC2 |
| In vitro study | BRD9539 decreases ATP levels in a dose-dependent manner in HeLa cells. BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration. However, BRD9539 has no activity in cell-based assays, presumably due to impaired cell permeability compared to that of BRD4770. In addition, the activities of 16 other chromatin-modifying enzymes and 100 kinases involved in cell-cycle regulation and cancer cell biology are tested for activity in the presence of 5 or 10 μM BRD9539; no activity is seen in any of these assays. |
BRD-9539 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
BRD-9539 - Reference
| Reference Show more | 1. Yuan, Y., Wang, Q., Paulk, J., et al. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma ACS Chem. Biol. 7(7), 1152-1157 (2012). |
BRD-9539 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.503 ml | 12.517 ml | 25.035 ml |
| 5 mM | 0.501 ml | 2.503 ml | 5.007 ml |
| 10 mM | 0.25 ml | 1.252 ml | 2.503 ml |
| 5 mM | 0.05 ml | 0.25 ml | 0.501 ml |
Last Update：2024-01-02 23:10:35
BRD-9539 - Reference Information
| biological activity | BRD9539 is a histone methyltransferase G9a inhibitor with IC50 of 6.3 μm. BRD9539 also inhibited PRC2 Activity and was inactive against SUV39H1,NSD2 and DNMT1. |
Last Update：2024-04-10 22:29:15
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Product Name: BRD9539 Visit Supplier Webpage Request for quotation
CAS: 1374601-41-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1374601-41-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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