BRIVUDINE
Brivudine
CAS: 69304-47-8
Molecular Formula: C11H13BrN2O5
BRIVUDINE - Names and Identifiers
| Name | Brivudine |
| Synonyms | BVDU Helpin BRIVUDINE Brivudine (E)-(5)-BROMOVINYL-2-DEOXYURIDINE E-5-(2-Bromovinyl)-2'-Deoxy-Uridine 5-(E)-(2-Bromovinyl)-2-deoxyuridine (E)-5-(2-bromovinyl)-2'-deoxyuridine (E)-5-(2-Bromovinyl)-2'-deoxyuridine (E)-5-(2-BROMOVINYL)-2'-DEOXY-URIDINE 5-[(E)-2-bromoethenyl]-2'-deoxyuridine Uridine,5-[(1E)-2-broMoethenyl]-2'-deoxy- 5-[(E)-2-bromoethenyl]-1-(2-deoxy-beta-L-erythro-pentofuranosyl)pyrimidine-2,4(1H,3H)-dione N-(2,6-dichloro-4-{[(2-chloroethyl)(methyl)amino]methyl}phenyl)-4,5-dihydro-1H-imidazol-2-amine dihydrochloride |
| CAS | 69304-47-8 |
| EINECS | 1806241-263-5 |
| InChI | InChI=1/C13H17Cl3N4.2ClH/c1-20(5-2-14)8-9-6-10(15)12(11(16)7-9)19-13-17-3-4-18-13;;/h6-7H,2-5,8H2,1H3,(H2,17,18,19);2*1H |
| InChIKey | ODZBBRURCPAEIQ-CXYVBZRVSA-N |
BRIVUDINE - Physico-chemical Properties
| Molecular Formula | C11H13BrN2O5 |
| Molar Mass | 333.14 |
| Density | 1.7800 (rough estimate) |
| Melting Point | 165°C |
| Boling Point | 382.9°C at 760 mmHg |
| Flash Point | 185.4°C |
| Water Solubility | Soluble in water and methanol. |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 4.56E-06mmHg at 25°C |
| Appearance | Solid |
| Color | Off-White |
| Merck | 14,1378 |
| pKa | 8.37±0.10(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.6520 (estimate) |
| MDL | MFCD00058585 |
| In vitro study | Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage. |
| In vivo study | At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia. |
BRIVUDINE - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | YU7355000 |
| HS Code | 29349990 |
BRIVUDINE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.002 ml | 15.009 ml | 30.017 ml |
| 5 mM | 0.6 ml | 3.002 ml | 6.003 ml |
| 10 mM | 0.3 ml | 1.501 ml | 3.002 ml |
| 5 mM | 0.06 ml | 0.3 ml | 0.6 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Spot supply
Product Name: Brivudine Visit Supplier Webpage Request for quotationCAS: 69304-47-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Brivudine Visit Supplier Webpage Request for quotationCAS: 69304-47-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History