BUCHE
BUCHE
CAS: 9001-08-5
Molecular Formula:
BUCHE - Names and Identifiers
| Name | BUCHE |
| Synonyms | BUCHE BUTYRYL CHOLINESTERASE BUTYRYLCHOLINE ESTERASE ACYLCHOLINE ACYL-HYDROLASE BUTYRYLCHOLINESTERASE, HUMAN CHOLINESTERASE BUTYRYL FROM HUMAN SERUM |
| CAS | 9001-08-5 |
| EINECS | 232-579-2 |
BUCHE - Physico-chemical Properties
| Melting Point | 177-178.1 °C(Solv: ligroine (8032-32-4)) |
| Solubility | cold water: soluble60 U/mL |
| Appearance | powder |
| Color | light brown |
| Merck | 13,2229 |
| Storage Condition | -20°C |
| MDL | MFCD00081455 |
| Use | Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities. BChE can, unlike AChE, efficiently hydrolyze larger esters of choline |
BUCHE - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
BUCHE - Reference
| Reference Show more | 1. Wang Miaomiao, Yan Huan, Tian He, et al. Antioxidant activity and enzyme inhibitory activity of lavender extract in vitro [J]. Science and Technology of food industry, 2019, 40(16). 2. Hao yarru, Li Ting, Zhang Wei, Li Shuguo. Rapid determination of malachite green in aquatic products by graphene-based butyrylcholinesterase biosensor [J]. Modern food science and technology, 2020,36(12):267-273. 3. [IF = 6.543] Zhang Jing et al."Studies of the Anti-amp Effects and Mechanisms of Single and Combined Use of Donepezil and gingko Ketoester Tablet on Scopolamine-Induced Memory impact in Mice." Oxid Med Cell Longev. 2019;2019:8636835 4. [IF = 4.379] Zhou Bohang et al."New 2-Aryl-9-methyl-β-carbolinium salts as Potential Acetylcholinesterase Inhibitor agents: Synthesis, Bioactivity and Structure-Activity Relationship."Sci Rep-Uk. 2018 Jan;8(1):1-18 5. [IF=7.46] Yue Zhang et al."A dual-signal sensing platform based on nanosheet materials for ratiometric fluorescence and colorimetric detection of enzyme activities in human blood."Sensor Actuat B- Chem. 2021 Nov;346:130531 6. [IF=6.514] Bohang Zhou et al."Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase."Eur J Med Chem. 2020 Aug;200:112415 |
BUCHE - Trait
Lyophilized powder containing buffer salts。
Last Update：2023-08-16 21:32:38
BUCHE - Source
Horse serum
Last Update：2023-08-16 21:32:38
BUCHE - Vitality
10 units/mg protein
Last Update：2023-08-16 21:32:38
BUCHE - Definition of enzyme activity
One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.
Last Update：2023-08-16 21:32:38
BUCHE - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Overview | Cholinesterase is a general term for a class of enzymes that decompose choline esters into choline and organic acids. It is a glycoprotein that exists in the body in the form of a variety of isoenzymes. Generally, it can be divided into true cholinesterase and pseudo-cholinesterase. True cholinesterase, also known as acetylcholinesterase (Acetylcholinesterase), mainly exists in the synaptic cleft of cholinergic nerve endings, especially in the folds of the postsynaptic membrane of the motor nerve endplate. It also exists in cholinergic neurons and red blood cells. |
| biological characteristics | cholinesterase is acetylcholinesterase (AChE), which is mainly distributed in nerve tissues, such as white matter and gray matter, nerve cells and neuromuscular junctions in ganglia, and non-nerve tissues such as red blood cells and serum. Under physiological conditions, the physiological function of AChE located on the membrane before and after synapses is mainly to catalyze the hydrolysis of acetylcholine. |
| Hydrolysis process | The process of acetylcholine hydrolysis by cholinesterase can be divided into three steps: ① The positively charged quaternary ammonium cation in the molecular structure of acetylcholine is combined with the anion site of cholinesterase by electrostatic attraction; at the same time, the carbonyl carbon in the acetylcholine molecule is combined with the hydroxyl group of serine at the cholinesterase esterification site in the form of covalent bonds, A complex of acetylcholine and cholinesterase is formed. ② Acetylcholine and cholinesterase complex cleaved into choline and acetylcholinesterase. (3) Acetylcholinesterase was rapidly hydrolyzed, acetic acid was isolated, and the activity of the enzyme was restored. |
| use | commonly used diagnostic enzymes. The activity of serum cholinesterase was determined. Cholinesterase assay kit. |
Last Update：2024-04-09 02:00:08
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Product Name: BUCHE Visit Supplier Webpage Request for quotationCAS: 9001-08-5
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Product Name: Butyrylcholinesterase Request for quotation
CAS: 9001/8/5
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Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 9001/8/5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
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