BUDDLEOSIDE
7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-4'-methoxyflavone
CAS: 480-36-4
Molecular Formula: C28H32O14
BUDDLEOSIDE - Names and Identifiers
| Name | 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-4'-methoxyflavone |
| Synonyms | linarin LINARIN BUDDLOSIDE BUDDLEOSIDE ACACETIN-7-RUTINOSIDE ACACETIN-7-O-RUTINOSIDE 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-4'-methoxyflavone 5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside 7-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one |
| CAS | 480-36-4 |
| EINECS | 207-547-6 |
| InChI | InChI=1/C28H32O14/c1-11-21(31)23(33)25(35)27(39-11)38-10-19-22(32)24(34)26(36)28(42-19)40-14-7-15(29)20-16(30)9-17(41-18(20)8-14)12-3-5-13(37-2)6-4-12/h3-9,11,19,21-29,31-36H,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1 |
BUDDLEOSIDE - Physico-chemical Properties
| Molecular Formula | C28H32O14 |
| Molar Mass | 592.55 |
| Density | 1.62±0.1 g/cm3(Predicted) |
| Melting Point | 258-260°C |
| Boling Point | 885.2±65.0 °C(Predicted) |
| Specific Rotation(α) | (Py)-90.3 |
| Flash Point | 292.2°C |
| Solubility | Soluble in hot methanol and DMSO, insoluble in petroleum ether and chloroform. |
| Vapor Presure | 1.36E-33mmHg at 25°C |
| Appearance | White powder |
| Color | White to Pale Beige |
| pKa | 6.11±0.40(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| Refractive Index | 1.693 |
| MDL | MFCD00151178 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, almost insoluble in ether, from the wild chrysanthemum, Thistle, Thistle. |
BUDDLEOSIDE - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
BUDDLEOSIDE - Reference
| Reference Show more | 1. Ma, Wen, Fang, Deng, Hui, Lian, Tang, Yurong, et al. Simultaneous determination of scutellarin and linarin in qiangyao sugar grass by HPLC [J]. China Pharmacy 2016 027(027):3845-3846 3847. 2. Xin Ying. Determination of linarin in Xiaoyan tablets by HPLC [J]. Science and Technology Innovation 2012(29):13-13. 3. Zhou Qingjun, Wang Tao, Guo Qiaosheng, et al. Effects of N P K regulation on medicinal part traits and active component content of Chrysanthemum indicum [J]. Chinese herbal medicine 2019 v.50;No.637(02):276-281. 4. Yuxiang Gong Qianfeng, Ye Yaohui, etc. Optimization of processing technology of Thistle by response surface methodology [J]. Chinese Pharmaceutical Journal 2012(24):1983-1986. 5. Zuozhiqin, Zeng Wenxue, Ding Yan, et al. Effect of linarin on MCF-7 androgen receptor [J]. Jiangxi traditional Chinese medicine, 2019, 050(001):62-64. 6. Sun Yuming, Wang Yuemei, Cai Rui, et al. Identification of chemical constituents in Verbena officinalis L. Extract by high performance liquid chromatography-photodiode array-high resolution mass spectrometry [J]. Chromatography, 2017, 35(009):987-994. 7. Xu Yiming, Wu Qi, Nan Lewei, et al. Analysis of organic acids and flavonoids in peppermint from different habitats [J]. Chinese herbal medicine 2018(2):299-302. 8. Zhang Jing, Zhang Jianyu, Li Da, et al. Correlation between microscopic characteristic constants and chemical components of Chrysanthemum indicum [J]. Shi Zhen, National Medicine, 2015, 026(005):1257-1259. 9. Zhi, Wang Xiaolin, Teng Songsong, Ma Chunhui, Yu Yinxian, Yi Chengqing. Linarin exerts anti-aging effect by eliminating aging phenotype of senescent bone marrow mesenchymal stem cells [J]. Advances in modern biomedicine, 2020,20(18):3407-3412. 10. Wang, Junshen, et al. "Inhibition receptor activator of nuclear factor kappa B ligand-induced NF-κB pathway." Biochemical and biomedical research communications 495.3 (2018): 2133-2138.https:// doi.org/10.1016/ 11. Jiang, Yanfeng Yang, et al. "Gene mining and identification of a flavone synthase II involved in flavones biosynthesis by transcriptomic analysis and targeted flavonoid profiling in Chrysanthemum indicum L." Industrial Crops and Products 134 (2019): 244-256 12. [IF=5.396] Bing-Xin Ma et al."Protective effects of Coptis chinensis inflorescence extract and linarin against carbon tetrachloride-induced damage in HepG2 cells through the MAPK/Keap1-Nrf2 pathway."Food Funct. 2018 Apr;9(4):2353-2361 13. [IF=2.985] Junsheng Wang et al."Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway."Biochem Bioph Res Co. 2018 Jan;495:2133 14. [IF=5.645] Yanfengyang Jiang et al."Gene mining and identification of a flavone synthase II involved in flavones biosynthesis by transcriptomic analysis and targeted flavonoid profiling in Chrysanthemum indicum L.."Ind Crop Prod. 2019 Aug;134:244 15. [IF=3.738] Yang Yating et al."Linarin Protects against Cadmium-Induced Osteoporosis Via Reducing Oxidative Stress and Inflammation and Altering RANK/RANKL/OPG Pathway."Biological Trace Element Research. 2021 Oct 21 16. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 17. [IF=2.629] Wang Ting et al."Network Pharmacology Prediction and Pharmacological Verification Mechanism of Yeju Jiangya Decoction on Hypertension."Evid-Based Compl Alt. 2021;2021:5579129 18. [IF=2.63] Sun Ke-han et al."Comparative Pharmacokinetics of Seven Major Compounds in Normal and Atherosclerosis Mice after Oral Administration of Simiao Yong'an Decoction."Evidence-based Complementary and Alternative Medicine. 2022;2022:4604601 19. [IF=4.36] Zhenhui Guo et al."Study on the mechanism of Cortex Lycii on lung cancer based on network pharmacology combined with experimental validation."J Ethnopharmacol. 2022 Apr;:115280 |
BUDDLEOSIDE - Reference Information
| action | linarin has anti-staphylococcus aureus and hemolytic streptococcus, anti-aging effect, anti-hypoxia effect, anti-adverse stimulation effect, two-way regulation of the body, anti-fatigue effect, inhibition of elevated blood sugar, toxicity and mutagenicity teratogenicity research, on learning and memory effects. |
| biological activity | Linarin (Buddleoside) is isolated from peppermint extract and selectively inhibits acetylcholinesterase (AChE). |
| use | linarin has anti-aging, anti-hypoxia, anti-adverse stimulation, two-way regulation of the body, anti-fatigue, inhibition of elevated blood sugar, toxicity and mutagenicity teratogenic effects. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: anti-aging effect, anti-hypoxia effect, anti-adverse stimulation effect, two-way regulation of the body, anti-fatigue effect, inhibition of blood sugar rise, toxicity and mutagenicity teratogenicity research, learning and memory impact. |
Last Update：2024-04-09 20:52:54
Supplier List
Spot supply
Product Name: Diosmin Impurity 5 (Diosmin EP Impurity E)(Linarin) Visit Supplier Webpage Request for quotationCAS: 480-36-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Buddleoside Visit Supplier Webpage Request for quotationCAS: 480-36-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Diosmin Impurity 5 (Diosmin EP Impurity E)(Linarin) Visit Supplier Webpage Request for quotationCAS: 480-36-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Buddleoside Visit Supplier Webpage Request for quotationCAS: 480-36-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History