BVT948

Name	4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE
Synonyms	BVT948 BVT 948 BVT-948(SPS8I-3) 4-HYDROXY-3,3-DIMETHYL-2H-BENZ[G]INDOLE-2,5(3H)-DIONE 4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE 2H-Benz[g]indole-2,5(3H)-dione, 4-hydroxy-3,3-dimethyl-
CAS	39674-97-0

Molecular Formula	C14H11NO3
Molar Mass	241.24
Density	1.39±0.1 g/cm3(Predicted)
Boling Point	400.8±55.0 °C(Predicted)
Solubility	DMSO: 18mg/mL
Appearance	solid
Color	red
pKa	5.78±0.40(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
In vitro study	Results show that the effect of BVT948 (BVT.948) is to strengthen the insulin signal and has no effects on the duration of the signal. BVT948 appears to be an effective inhibitor of both protein tyrosine phosphatases (PTP activity and P450 activity). BVT948 efficiently and selectively suppresses cellular H4 lysine 20 (H4K20me1) at doses lower than 5 μM within 24 h. The cells treated with BVT948 recapitulate cell-cycle-arrest phenotypes similar to what are reported for knocking down SETD8 by RNAi. Treatment of MCF-7 cells with 0.5, 1 or 5 μM of BVT948 for 24 h does not cause any significant changes in cell viability. BVT948 inhibits TPA-induced MMP-9 up-regulation in a dose-dependent manner. Treatment with BVT948 inhibits TPA-stimulated NF-κB binding activity, but not AP-1 binding activity. BVT948 does not affect the MAPK phosphorylation by TPA. Treatment with BVT948 diminishes the TPA-induced cell invasion by 50%.
In vivo study	Results show that 3 μmol/kg BVT948 (BVT.948) significantly enhances glucose clearance from the blood stream in response to insulin compare with vehicle-treated controls.

Hazard Symbols	Xi - Irritant
Risk Codes	43 - May cause sensitization by skin contact
Safety Description	36/37 - Wear suitable protective clothing and gloves.
WGK Germany	3

Last Update：2024-01-02 23:10:35

biological activity	BVT948 is an inhibitor of protein tyrosine phosphatase (PTP), several cytochrome P450 (P450) isomers and Lysine Methyltransferase SETD8 (KMT5A) can also be inhibited.
Target	PTP, P450, SETD8

Last Update：2024-04-09 19:05:16

Product Name: 4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE Visit Supplier Webpage Request for quotation
CAS: 39674-97-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Wechat: 18301782025

View History

BVT948

BVT948 Request for Quotation