BYK61359
Soraprazan
CAS: 261944-46-1
Molecular Formula: C21H25N3O3
BYK61359 - Names and Identifiers
| Name | Soraprazan |
| Synonyms | BYK61359 Soraprazan Imidazo[1,2-h][1,7]naphthyridin-8-ol, 7,8,9,10-tetrahydro-7-(2-methoxyethoxy)-2,3-dimethyl-9-phenyl-, (7R,8R,9R)- |
| CAS | 261944-46-1 |
BYK61359 - Physico-chemical Properties
| Molecular Formula | C21H25N3O3 |
| Molar Mass | 367.44 |
| Density | 1.29±0.1 g/cm3(Predicted) |
| Solubility | DMSO |
| pKa | 12.77±0.60(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Soraprazan (BYK61359) is a potent inhibitor of gastric H,K-ATPase, with an IC 50 of 0.1 μM when measured in ion-leaky vesicles in the presence of 1 mM potassium. Soraprazan (BYK61359) also effectively inhibits dibutyryl cAMP-stimulated [ 14 C]AP accumulation in isolated gastric glands with an IC 50 of 0.19 μM (0.09-0.40 μM geometric mean from n=6 with 95% confidence limits). |
| In vivo study | Soraprazan (1-27 μmol/kg; p.o.) shows rapid and consistent inhibition of acid secretion in dog . |
BYK61359 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.722 ml | 13.608 ml | 27.215 ml |
| 5 mM | 0.544 ml | 2.722 ml | 5.443 ml |
| 10 mM | 0.272 ml | 1.361 ml | 2.722 ml |
| 5 mM | 0.054 ml | 0.272 ml | 0.544 ml |
Last Update：2024-01-02 23:10:35
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