Bardoxolone Methyl (RTA 402)
2-Cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid methyl ester
CAS: 218600-53-4
Molecular Formula: C32H43NO4
Bardoxolone Methyl (RTA 402) - Names and Identifiers
| Name | 2-Cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid methyl ester |
| Synonyms | TP155 TP-155 TP-155 RTA402 CDDOME TP 155 TP-155C CDDO-Me RTA-402 RTA 402 NSC 713200 NSC 713200 CDDO-METHYL ESTER BARDOXOLONE METHYL CDDO METHYL ESTER Bardoxolone Me ester Bardoxolone Methyl (RTA 402) methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate 2-Cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid methyl ester Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester Methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester (6aR,6bS,8aR,12aS,14aR,14bS)-11-Cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxylic acid methyl ester |
| CAS | 218600-53-4 |
| EINECS | 606-850-4 |
| InChI | InChI=1/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1 |
Bardoxolone Methyl (RTA 402) - Physico-chemical Properties
| Molecular Formula | C32H43NO4 |
| Molar Mass | 505.69 |
| Density | 1.15 |
| Melting Point | 215-223°C |
| Boling Point | 600.8±55.0 °C(Predicted) |
| Flash Point | 256.5°C |
| Solubility | Soluble in DMSO, not in water |
| Vapor Presure | 2.15E-14mmHg at 25°C |
| Appearance | White to off-white solid powder |
| Color | White to Light Brown |
| Storage Condition | Refrigerator |
| Refractive Index | 1.558 |
| MDL | MFCD11983137 |
| In vitro study | Bardoxolone Methyl acts on mouse macrophages and has a strong inhibitory activity on the production of nitric oxide induced by interferon, with an IC50 of 0.1 nM. Bardoxolone Methyl reduced the viability of leukemia HL-60,KG-1, and NB4 cells with IC50 of 0.4,0.4, and 0.27 μm, respectively. CDDO-ME induces pro-apoptotic Bax protein expression, inhibits the activation of ERK1/2, and it inhibits the phosphorylation of Bcl-2, which contributes to the induction of apoptosis. Bardoxolone Methyl potently inhibits (IL)-1beta, phorbol ester, okadaic acid, hydrogen peroxide, lipopolysacchar, and cigarette smoke activation of constitutive and inducible NF-κB tumor necrosis factor. |
| In vivo study | Bardoxolone Methyl(60 mg/kg), administered in vivo, reduces the number, size and severity of lung tumors. Bardoxolone Methyl can also significantly reduce the response of in vivo inflammatory factors stimulated by LPS, induce the expression of HO-1 protein in spleen, and protect mice against lethal doses of LPS. |
Supplier List
Spot supply
Product Name: RTA 402; NSC 713200; CDDO Methyl ester Visit Supplier Webpage Request for quotationCAS: 218600-53-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Bardoxolone methyl Visit Supplier Webpage Request for quotationCAS: 218600-53-4
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Bardoxolone Methyl Visit Supplier Webpage Request for quotationCAS: 218600-53-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Bardoxolone Methyl Visit Supplier Webpage Request for quotationCAS: 218600-53-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: RTA-402 Visit Supplier Webpage Request for quotationCAS: 218600-53-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: RTA 402; NSC 713200; CDDO Methyl ester Visit Supplier Webpage Request for quotationCAS: 218600-53-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Bardoxolone methyl Visit Supplier Webpage Request for quotationCAS: 218600-53-4
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Bardoxolone Methyl Visit Supplier Webpage Request for quotationCAS: 218600-53-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Bardoxolone Methyl Visit Supplier Webpage Request for quotationCAS: 218600-53-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: RTA-402 Visit Supplier Webpage Request for quotationCAS: 218600-53-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Bardoxolone Methyl (RTA 402)
3-Pyrrolidinol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (3R,4R)-
tributyl(pyrimidin-2-yl)stannane
磷酸奥司他韦
1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-AMINE
110763-09-2
(2R)-2-methylcyclohexanone
2-溴-2'-氯苯乙酮
Pentane-2,4-dicarboxylic acid diethyl ester
Benzaldehyde, 2-chloro-6-methoxy-
3-Pyrrolidinol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (3R,4R)-
tributyl(pyrimidin-2-yl)stannane
磷酸奥司他韦
1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-AMINE
110763-09-2
(2R)-2-methylcyclohexanone
2-溴-2'-氯苯乙酮
Pentane-2,4-dicarboxylic acid diethyl ester
Benzaldehyde, 2-chloro-6-methoxy-