Bemegride

Name	Bemegride
Synonyms	NP-13 EUKRATON Bemegride 3,3-Methylethylilotarimide β,β-Methylethylglutarimide 3-Ethyl-3-methylglutarimide 3-Methyl-3-ethylglutarimide 4-Ethyl-4-methyl-2,6-piperidinedione 4-ethyl-4-methylpiperidine-2,6-dione 2,6-DIOXO-4-METHYL-4-ETHYLPIPERIDINE 4-Ethyl-4-methylpiperidine -2,6-dione 2,6-Piperidinedione, 4-ethyl-4-methyl-
CAS	64-65-3
EINECS	200-588-0
InChI	InChI=1/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2,1-2H3,(H,9,10,11)

Molecular Formula	C8H13NO2
Molar Mass	155.19
Density	1.1174 (rough estimate)
Melting Point	126-127°C(lit.)
Boling Point	279°C (rough estimate)
Flash Point	125.8°C
Water Solubility	Soluble in water
Solubility	Soluble in water, acetone, slightly soluble in ethanol.
Vapor Presure	0.00344mmHg at 25°C
Appearance	White crystalline powder or flake crystal
Color	white
Merck	14,1027
pKa	pKa 11.7 (Uncertain)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.4860 (estimate)
MDL	MFCD00006673
Physical and Chemical Properties	White crystalline powder or flake Crystal, odorless, bitter taste. Melting point 127 °c. Sublimation at 100 ℃, 0.267kPa, soluble in water, acetone, slightly soluble in ethanol.
In vitro study	Bemegride has an antagonistic effect on GABA A receptors and is able to inhibit GABA-and pentobarbital-induced whole-cell currents with similar amplitudes.
In vivo study	Barbital alone, or in combination with the stimulants bemegride or pentylenetetrazol in rats chronically administered orally, the intensity of the withdrawal syndrome is roughly parallel to the degree of associated central nervous system depression.

Hazard Symbols	T - Toxic
Risk Codes	23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
Safety Description	S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	MA4550000
Hazard Class	6.1(a)
Packing Group	II
Toxicity	LD50 in male mice (mg/kg): 20.1 ±1.41 i.v., 43.0 ±1.8 s.c.; LD50 in male rats (mg/kg): 16.3 ±1.24 i.v., 23.5 ±1.67 i.p (Hahn, Oberdorf)