Benzhexol
Trihexylphenedyl
CAS: 144-11-6
Molecular Formula: C20H31NO
Benzhexol - Names and Identifiers
| Name | Trihexylphenedyl |
| Synonyms | Artane Benzhexol benzhexol Trihexyphenidyl rihexylphenedyl Trihexylphenedyl 1-Cyclohexyl-1-phenyl-3-piperidino-1-propanol 1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol α-Cyclohexyl-α-(2-piperidinoethyl)benzenemethanol 1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol 1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol (R)-1-Cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride |
| CAS | 144-11-6 |
| EINECS | 205-614-4 |
| InChI | InChI=1/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2 |
Benzhexol - Physico-chemical Properties
| Molecular Formula | C20H31NO |
| Molar Mass | 301.47 |
| Density | 0.9941 (rough estimate) |
| Melting Point | 258.5°C |
| Boling Point | 442.59°C (rough estimate) |
| Flash Point | 211°C |
| Vapor Presure | 8.34E-09mmHg at 25°C |
| pKa | 14.31±0.29(Predicted) |
| Refractive Index | 1.5614 (estimate) |
Benzhexol - Risk and Safety
| Toxicity | LD50 ipr-mus: 150 mg/kg ARZNAD 21,1727,71 |
Benzhexol - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) | |
| introduction | benhexol, as an anti-Parkinson's disease drug, was listed abroad in the 1950 s and began to be listed in China in the 1960 s. This product is a central anticholinergic and anti-Parkinson's disease drug. It is used to treat senile shock diseases. Its role is to selectively block the cholinergic nerve pathway in the striatum, and has less peripheral effect, which is beneficial to restore Parkinson's disease The balance of dopamine and acetylcholine in the brain of patients improves the symptoms of Parkinson's disease. | |
| clinical application | clinical application | clinical application is used for paralysis agitans, paralysis agitans caused by encephalitis or arteriosclerosis. it is effective for improving salivation, poor curative effect for relieving rigidity and retardation, and obvious improvement of tremor, but the overall curative effect is not as good as levodopa and amantadine. It is used in patients with mild illness and intolerance of levodopa, often combined with levodopa. Hepatolenticular degeneration. Deformed dystonia, epilepsy, chronic schizophrenia, akathisia caused by antipsychotic drugs. It can also be used for extrapyramidal diseases caused by drugs. benhexol is clinically used for tremor paralysis caused by encephalitis or arteriosclerosis. it is effective in improving salivation, and has poor curative effect on relieving rigidity and retardation. it has obvious improvement of tremor, but the overall curative effect is not as good as levodopa and amantadine. It is used in patients with mild illness and intolerance of levodopa, often combined with levodopa. Hepatolenticular degeneration. Deformed dystonia, epilepsy, chronic schizophrenia, akathisia caused by antipsychotic drugs. It can also be used for extrapyramidal diseases caused by drugs. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:49:11
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