Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite - Names and Identifiers

Name	bis(2-cyanoethyl) diisopropylphosphoramidite
Synonyms	bis(2-cyanoethyl) diisopropylphosphoramidite Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite Bis(2-cyanoethyl) N,N-bis(isopropyl)phosphoramidite PhosphoraMidous acid,N,N-bis(1-Methylethyl)-, bis(2-cyanoethyl) ester Bis(2-cyanoethoxy)(diisopropylamino)phosphine, Bis(2-cyanoethoxy)-N,N-diisopropylaminophosphine Bis(2-cyanoethyl) di(prop-2-yl)phosphoramidoite, Bis(2-cyanoethyl) N,N-diisopropylphosphoramidite
CAS	102690-88-0
EINECS	802-449-5

Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite - Physico-chemical Properties

Molecular Formula	C12H22N3O2P
Molar Mass	271.296
Density	1.039 g/mL at 25 °C
Boling Point	335.3±27.0 °C(Predicted)
Flash Point	73℃
Appearance	Clear or slightly yellow Liquid
pKa	3.11±0.70(Predicted)
Storage Condition	-20°C
Refractive Index	n20/D1.465

Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite - Risk and Safety

Risk Codes	R23 - Toxic by inhalation R24 - Toxic in contact with skin R25 - Toxic if swallowed R36 - Irritating to the eyes R38 - Irritating to the skin
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37 - Wear suitable gloves. S39 - Wear eye / face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2810 6.1 / PGIII
WGK Germany	3
Hazard Class	IRRITANT

Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite - Introduction

bis(2-cyanoethyl) diisopropylphosphoramidite is an organophosphorus compound with the chemical formula C10H18N3OP. Here is some information about it:

Nature:
-Appearance: colorless liquid
-Molecular weight: 227.26g/mol
-Boiling point: 160-165 ° C
-Melting point:-57 ° C

Use:
bis(2-cyanoethyl) diisopropylphosphoramidite is commonly used as an important reagent in the chemical synthesis of nucleic acids. It can be used as a phosphorylating reagent in the synthesis of DNA and RNA, and also in solid-phase synthesis reactions.

Method:
bis(2-cyanoethyl) diisopropylphosphoramidite can be prepared by the reaction of triethylamino chlorocyanophos and diisopropyl alcohol. Specific steps involve mixing and heating the reactants, followed by crystallization or distillation purification.

Safety Information:
- bis(2-cyanoethyl) diisopropylphosphoramidite is an irritating chemical. Contact with skin and eyes may cause irritation and burns. Please be careful to avoid direct contact.
-Wear appropriate personal protective equipment such as laboratory gloves and goggles during use.
-should be in a well ventilated place to operate, avoid inhalation of gas or steam.
-Should be stored in a closed container, away from fire and oxidizing agents.

Please note that the above information is for reference only. Refer to the official Chemical Safety Data Sheet (MSDS) and other relevant safety guidelines when using or handling this compound.

Last Update：2024-04-10 22:29:15