Bis(O-trimethylsilyl)thymine - Names and Identifiers
Bis(O-trimethylsilyl)thymine - Physico-chemical Properties
| Molecular Formula | C11H22N2O2Si2
|
| Molar Mass | 270.476 |
| Density | 0.974g/cm3 |
| Melting Point | 73-75 °C(lit.) |
| Boling Point | 290.6°C at 760 mmHg |
| Flash Point | 129.6°C |
| Vapor Presure | 0.00356mmHg at 25°C |
| Appearance | morphological solid |
| pKa | 1.50±0.29(Predicted) |
| Refractive Index | 1.463 |
| Physical and Chemical Properties | EPA Chemical Information Pyrimidine, 5-methyl-2,4-bis[(trimethylsilyl)oxy]- (7288-28-0) |
Bis(O-trimethylsilyl)thymine - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
|
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
|
| WGK Germany | 3 |
| TSCA | No |
Bis(O-trimethylsilyl)thymine - Upstream Downstream Industry
Bis(O-trimethylsilyl)thymine - Introduction
Bis(O-trimethylsilyl)thymine is an organic compound with the chemical formula C16H32N2O2Si2.
The following are some of the properties and characteristics of Bis(O-trimethylsilyl)thymine:
1. Appearance: white or almost white crystal or powder.
2. melting point: about 143-146 c.
3. Solubility: Soluble in organic solvents such as methanol and dichloromethane, insoluble in water.
Bis(O-trimethylsilyl)thymine is often used in organic synthesis and biochemical research. Its main uses include the following:
1. Protecting group: Typically, it can be used as a protecting group in DNA and RNA bases to prevent other reactions from changing it.
2. Selectivity of amplification of specific base pairs: By acting as a selective probe of a specific base pair in a PCR reaction, it can be amplified at a specific position.
3. fluorescent probe: can be fluorescent staining or labeling for cell biology and molecular biology research.
The method for preparing Bis(O-trimethylsilyl)thymine is as follows:
The product can be obtained by placing 1-(O-tri (methyl) silyl) ethylthymidine in toluene treated with chlorine gas, using iron as a catalyst, and reacting at 60-80°C.
For safety information, please note the following:
1. Bis(O-trimethylsilyl)thymine, although widely used in the laboratory, should still be operated with caution.
2. During operation, please pay attention to personal protective measures, such as wearing chemical protective gloves, protective glasses and laboratory coats.
3. Avoid inhaling substances, so it is best to perform in a well-ventilated area during operation and wear suitable respiratory protective equipment.
4. Avoid contact with skin and eyes. In case of contact, rinse with plenty of water immediately and seek medical help.
5. When storing, the Bis(O-trimethylsilyl)thymine should be stored in a sealed container, away from oxidants and high temperatures.
Last Update：2024-04-10 22:41:03