Bisacodyl

Bisacodyl - Names and Identifiers

Name	Bisacodyl
Synonyms	Bisacodyl 2-(4,4'-diacetoxydiphenylmethyl)pyridine 2-(4,4'-Diacetoxydiphenylmethyl)pyridine 4,4'-(2-pyridylmethylene)-diphenolacetate 4,4'-(2-Pyridylmethylene)-diphenolace-tate 4,4'-(2-Pyridylmethylene)diphenol diacetate alpha-(2-pyridyl)benzhydryl-4,4-diyl di(acetate) 4,4'-(2-pyridylmethylene)di-phenodiacetate(ester) 4,4'-(2-Pyridylmethylene)diphenol diacetate (ester) 4,4'-(2-pyridinylmethylene)bis-phenodiacetate(ester)
CAS	603-50-9
EINECS	210-044-4
InChI	InChI=1/C22H19NO4/c1-15(24)26-19-10-6-17(7-11-19)22(21-5-3-4-14-23-21)18-8-12-20(13-9-18)27-16(2)25/h3-14,22H,1-2H3
InChIKey	KHOITXIGCFIULA-UHFFFAOYSA-N

Bisacodyl - Physico-chemical Properties

Molecular Formula	C22H19NO4
Molar Mass	361.39
Density	1.2545 (rough estimate)
Melting Point	138°C
Boling Point	493.21°C (rough estimate)
Water Solubility	Soluble in alcohol (slightly), ether (slightly), chloroform, and acetone. Insoluble in water.
Solubility	Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids.
Appearance	neat
Color	White to Off-White
Maximum wavelength(λmax)	['220nm(MeOH)(lit.)']
Merck	14,1242
pKa	4.69±0.10(Predicted)
Storage Condition	Sealed in dry,2-8°C
Stability	Stable. Incompatible with strong oxidizing agents.
Refractive Index	1.5614 (estimate)
Use	Is a safe and effective laxative for the treatment of constipation
In vitro study	Bisacodyl (10 μg/ml) increased mRNA expression levels of TNF-α,COX2 and PGE2 in Raw264.7 cells.
In vivo study	In the rat colon, Bisacodyl (20 mg/kg) caused a decrease in AQP3 protein expression and an increase in the mRNA expression level of TNF-α. Bisacodyl inhibited rat jejunum, ileum, and colon water uptake in the range of 0.05 mg to 2.0 mg/100 ml, with a linear correlation to the logarithm of bisacodyl concentration. Bisacodyl (10 mg/kg, gavage) caused a significant decrease in the activity of NOS in rat jejunum. Bisacodyl (10 mg/kg, gavage) increased travel distance for all time period markers. Bisacodyl (5.9 mg/kg) significantly reduced rat jejunum and colon (Na K) ATPase activity compared to saline-treated rats. Bisacodyl (5.9 mg/kg) significantly increased the content of PGE2 in jejunum and colon and stimulated the activity of adenylate cyclase in jejunum and colon compared with control rats which did not affect the content of cAMP. Bisacodyl (4.3 mg/kg) together with AOM increased the number of sacs per colony in rats, but not the number of tumors. Bisacodyl (4.3 mg/kg) significantly increased the number of sacs and tumors per colony in rats.

Bisacodyl - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
RTECS	SM8750000
TSCA	Yes
HS Code	2933399090
Toxicity	LD50 orally in rats: >3 g/kg (Schmidt)

Bisacodyl - Upstream Downstream Industry

Raw Materials

Phenol

Bisacodyl - Standard

Authoritative Data Verified Data

This product is 4,4 '(2-pyridylmethylene) diphenol diacetate. Calculated as dried product, the content of C22H19N04 shall not be less than 98.0%.

Last Update：2024-01-02 23:10:35

Bisacodyl - Trait

Authoritative Data Verified Data

This product is white or off-white crystalline powder; Odorless.
This product is soluble in chloroform, soluble in acetone, slightly soluble in ethanol or ether, insoluble in water.

melting point

The melting point of this product (General 0612) is 132~136°C.

Last Update：2022-01-01 11:32:14

Bisacodyl - Differential diagnosis

Authoritative Data Verified Data

take this product, add 0.1 mol / L methanol to potassium hydroxide solution is made into a solution containing 10ug per 1 ml, which is determined by ultraviolet-visible spectrophotometry (General rule 0401) and has the maximum absorption at the wavelength of 248nm, the absorbance was 0.62 to 0.68.
The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 35).

Last Update：2022-01-01 11:32:15

Bisacodyl - Exam

Authoritative Data Verified Data

pH

take l.Og of this product, add 20ml of water, heat to boiling, cool, filter, and determine the filtrate according to law (General rule 0631). The pH value should be 5.0~7.5.

Related substances

take this product and add acetone to make a solution containing about 20mg per lml as a test solution; Take an appropriate amount of precision and dilute with acetone to make a solution containing about 0.20mg per lml, as a control solution. Take about 40mg of this product, add acetone 1ml, shake to dissolve, add 30% hydrogen peroxide solution 0.5ml, shake, place for 1 hour, dilute to 2ml with acetone, shake, as a system suitability solution. According to the thin layer chromatography (General 0502) test, draw the applicable solution of the system, the test solution and the control solution l0ul, respectively, on the same silica gel GF254 thin layer plate, with xylene-methyl ethyl ketone (1:1) as the developing solvent, expand, dry, set the UV lamp (254mn) to view, the system is applicable. The impurity spots in the solution should be clearly separated from the spots of bisacodyl, the personal value of bisacodine should be about 0.7. Test solution such as impurity spots, compared with the control solution of the main spot, not deeper (1.0%).

loss on drying

take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).

ignition residue

not more than 0.1% (General rule 0841).

Last Update：2022-01-01 11:32:15

Bisacodyl - Content determination

Authoritative Data Verified Data

take this product about 0.3g, precision weighing, add glacial acetic acid 25ml dissolved, add naphthol benzyl alcohol indicator solution 2 drops, with perchloric acid titration solution (0.1 mol/L) titration to the solution yellow green, and the results of the titration with blank test correction. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 36.14 mg of C22H19NO4.

Last Update：2022-01-01 11:32:16

Bisacodyl - Category

Authoritative Data Verified Data

laxative.

Last Update：2022-01-01 11:32:16

Bisacodyl - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 11:32:16

Bisacodyl - Bisacodyl enteric-coated tablets

Authoritative Data Verified Data

This product contains 93.0% ~ 107.0% of the label amount of bisacodyl (C22H19N04).

trait

This product is an enteric-coated tablet, White after removing the coating.

identification

take an appropriate amount of fine powder of this product (about 50mg equivalent to bisacodyl), add chloroform 30ml, shake to dissolve Bisacodyl, filter, and evaporate the filtrate to dryness, 10ml of 1% sulfuric acid solution was added to dissolve the residue, and the test was carried out according to the following method. 2ml of the solution was taken, and 1 drop of the test solution of Mercury iodide was added to generate a white precipitate. 2ml of the solution was taken, and sulfuric acid was added dropwise, which showed a purplish red color. Take 2ml of the solution, add 1~2 drops of nitric acid, heat, yellow, cool, Dropwise add sodium hydroxide solution, yellow brown.
take an appropriate amount of fine powder of this product (about 20mg equivalent to bisacodyl), add 2ml of acetone, shake for 10 minutes, centrifuge, and take the supernatant as the test solution, A solution containing 10mg per 1 ml was prepared by adding acetone as a control solution. According to the thin layer chromatography (General 0502) test, absorb 2ul of each of the above two solutions, respectively point on the same silica gel GF254 thin layer plate, with xylene-methyl ethyl ketone (1:1) as the developing solvent, open, dry, and set the UV light (254nm) to view. The position and color of the main spot displayed by the test solution should be consistent with the main spot of the control solution.

examination

appropriate amount of fine powder under the content determination item (about 20mg equivalent to bisacodyl), add 2ml of acetone, shake for 10 minutes, centrifuge, and take the supernatant as the test solution; 0.3ml of the test solution was accurately collected and diluted with acetone to 10ml, and used as a control solution. Determination according to the method under related substances of bisacodyl. Test solution such as impurity spots, compared with the control solution of the main spot, not deeper (3.0%).
Content uniformity: Take 1 tablet of this product, remove the coating, put it in a mortar, grind it finely, add an appropriate amount of chloroform, grind it, and transfer it to a 25ml measuring flask in portions with chloroform, shake to dissolve Bisacodyl, dilute to the scale with chloroform, shake well, filter, Take 5ml of the continuous filtrate, place it in another 25ml measuring flask, dilute to the scale with chloroform, shake well, determination of content according to the method under the content determination item, should comply with the provisions (General 0941).
others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).

Content determination

Take 20 tablets of this product, remove the coating, precision weighing, fine, precision weighing an appropriate amount (equivalent to 20mg of bisacodyl), put it in a 50ml measuring flask, add an appropriate amount of chloroform, shake to dissolve Bisacodyl, dilute to the scale with chloroform, shake well, filter, Take 5ml of the continuous filtrate, place it in another 50ml measuring flask, dilute to the scale with chloroform, shake well, the absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (General Rule 148), and the absorbance was calculated as for C22H19N04.

specification

5mg

storage

protected from light and sealed.

Last Update：2022-01-01 11:32:17

Bisacodyl - Bisacodyl suppositories

Authoritative Data Verified Data

This product contains 90.0% ~ 110.0% of the label amount of bisacodyl (C22H19N04).

trait

This product is a white suppository made of water-soluble or fatty base.

identification

take 1 capsule of this product, add 3ml of 1% sulfuric acid solution, heat to melt, Dropwise add 4~5 drops of nitric acid, heat yellow, add 10 drops of 20% sodium hydroxide solution, brownish-red.
take 1 granule of this product, add 10ml of acetonitrile, melt at a slight temperature, let it cool, put it in an ice bath and precipitate out of the matrix, quickly filter it, and take the filtrate as the test solution; A control solution containing 1 mg per 1 ml was prepared by dissolving and diluting the reference substance with acetonitrile. According to the thin layer chromatography (General 0502) test, absorb 20 u1 of each of the above two solutions, respectively point on the same silica gel GF254 thin layer plate, with xylene-methyl ethyl ketone (1:1) as the developing solvent, expand, dry, and set the UV lamp (254mn) to view. The position and color of the main spot of the test solution should be consistent with the main spot of the reference solution.
the solution under the content measurement was measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at a wavelength of Nm.

examination

Content uniformity take 1 capsule of this product, put it in a 100ml measuring flask, add an appropriate amount of 1 mol/L hydrochloric acid solution, put it in a water bath, shake to dissolve Bisacodyl, cool it, dilute with 1 mol/L hydrochloric acid solution to the scale, shake well (such as for the suppository made of fatty matrix, filter); Take 10ml precision, put in 50ml measuring flask, dilute to the scale with lmol/L hydrochloric acid solution, shake well, and determine the content according to the method under the item of content determination, which shall comply with the regulations (General rule 0941).
others should comply with the relevant provisions under suppository (General rule 0107).

Content determination

Take 10 pieces of this product, put it in an evaporation dish, put it on a water bath and heat it to melt, cool it and stir it constantly to make it mix well. Add appropriate amount of hydrochloric acid solution (1 mol/L) to a 100ml measuring flask, place it in a water bath, shake to dissolve bisacodine, and cool, dilute with lmol/L hydrochloric acid solution to the scale, shake well (such as for the suppository made of fatty matrix, filter), take 10ml, put it in a 100ml measuring flask, dilute with lmol/L hydrochloric acid solution to the scale, shake well, measure absorbance at the wavelength of 264nm according to UV-visible spectrophotometry (General rule 0401), 1 mol/L hydrochloric acid solution was added to dissolve and quantitatively dilute to prepare a solution containing about 20ug per 1 ml, which was determined by the same method. It is obtained by calculation.

specification

lOmg

storage

sealed and stored at 30°C or less.

Last Update：2022-01-01 11:32:18

Hefei TNJ Chemical Industry Co.,Ltd.

Product Name: Bisacodyl Request for quotation
CAS: 603-50-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
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Shanghai Yuanye Bio-Technology Co., Ltd.

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Product Name: Bisacodyl Visit Supplier Webpage Request for quotation
CAS: 603-50-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Hefei TNJ Chemical Industry Co.,Ltd.

Product Name: Bisacodyl Request for quotation
CAS: 603-50-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840

Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog

Shanghai Yuanye Bio-Technology Co., Ltd.

Multiple SpecificationsSpot supply

Product Name: Bisacodyl Visit Supplier Webpage Request for quotation
CAS: 603-50-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

Bisacodyl
N-甲酰头孢泊肟酯

Raw Materials for Bisacodyl

Phenol

Bisacodyl Request for Quotation

Bisacodyl

CAS: 603-50-9

Molecular Formula: C22H19NO4

Bisacodyl - Names and Identifiers

Bisacodyl - Physico-chemical Properties

Bisacodyl - Risk and Safety

Bisacodyl - Upstream Downstream Industry

Bisacodyl - Standard

Authoritative Data Verified Data

Bisacodyl - Trait

Authoritative Data Verified Data

melting point

Bisacodyl - Differential diagnosis

Authoritative Data Verified Data

Bisacodyl - Exam

Authoritative Data Verified Data

pH

Related substances

loss on drying

ignition residue

Bisacodyl - Content determination

Authoritative Data Verified Data

Bisacodyl - Category

Authoritative Data Verified Data

Bisacodyl - Storage

Authoritative Data Verified Data

Bisacodyl - Bisacodyl enteric-coated tablets

Authoritative Data Verified Data

trait

identification

examination

Content determination

category

specification

storage

Bisacodyl - Bisacodyl suppositories

Authoritative Data Verified Data

trait

identification

examination

Content determination

category

specification

storage

Supplier List

Bisacodyl