Blaes
BLASTICIDIN S
CAS: 2079-00-7
Molecular Formula: C17H26N8O5
Blaes - Names and Identifiers
| Name | BLASTICIDIN S |
| Synonyms | bab Blas Blaes BLASTICIDIN S 1(1'-Cytosinyl)-4-[L-3'-amino-5'(1''-N-methylguanidino)valerlamino]1,2,3,4-te-tradeoxy-D-erythro-hex-2-enuronicacid 1(1'-Cytosinyl)-4-[L-3'-amino-5'(1''-N-methylguanidino)valerlamino]1,2,3,4-te-tradeoxy-D-erythro-hex-2-enuronic acid .beta.-D-erythro-Hex-2-enopyranuronic acid, 4-3-amino-5-(aminoiminomethyl)methylamino-1-oxopentylamino-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-, (S)- |
| CAS | 2079-00-7 |
Blaes - Physico-chemical Properties
| Molecular Formula | C17H26N8O5 |
| Molar Mass | 422.45 |
| Density | 1.1690 (rough estimate) |
| Melting Point | 235°C |
| Boling Point | 539.06°C (rough estimate) |
| Specific Rotation(α) | D11 +108.4° (water) |
| Water Solubility | >30 g l-1(20 °C) |
| Vapor Presure | Low |
| pKa | 2.4 (carboxyl), 4.6,8.0 and>12.5 (three bases) |
| Stability | Incompatible with strong oxidizing agents. |
| Refractive Index | 1.6910 (estimate) |
| Physical and Chemical Properties | Chemical properties white needle crystal, m.p.253 ~ 255 ℃,[α]D +108.4o, hydrochloride white crystal, m.p.202 ~ 204 ℃ (decomposition). It is soluble in acetic acid, hardly soluble in most organic solvents, and has 12.5% solubility in water. Chemical properties are stable. |
| Use | Use of agricultural antibiotics. It has the effect of inhalation therapy, mainly used for the prevention and control of rice blast, can inhibit the growth of spores and hyphae of rice production, and can also inhibit a variety of bacteria and other fungi, such as tobacco mosaic disease and Rice stripe Virus also inhibited. 500~1000 times of 2% emulsifiable concentrate can be used to control rice leaf blast and panicle neck blast. |
Blaes - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | 28 - Very Toxic if swallowed |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3172 |
| HS Code | 29349990 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
| Toxicity | LD50 i.v. in mice: 2.82 mg/kg (Takeuchi) |
Blaes - Upstream Downstream Industry
Blaes - Nature
| specific rotation | D11 108.4° (water) |
| acidity coefficient (pKa) | 2.4 (carboxyl), 4.6,8.0 and>12.5 (three bases) |
| water solubility | >30g l-1(20 °C) |
| stability | Incompatible with strong oxidizing agents. |
| EPA chemical information | Blasticidin S (2079-00-7) |
Last Update：2024-04-10 22:29:15
Blaes - Uses and synthesis methods
Toxicity
the original drug was used for acute oral LD5056.8mg/kg in male rats, 5055.9mg/kg in female rats, acute percutaneous LD50>500mg/kg in rats, and acute inhalation of LC50<0.0032mg/L (4h) in rats. With regard to the acute toxicity of desquamate, there are also reports that soda ash crystallization has an acute oral LD5022.5 mg/kg for mice, which is 158 mg/kg and 53.5 mg/kg for benzyl sulfamate after being made into hydrochloride. It is irritating to human eyes and skin. Inadvertently entering the eyes can cause conjunctivitis and rash on the skin. No carcinogenic, teratogenic and mutagenic effects were found in animal experiments. Carp LC50>40mg/L (48h).
use
agricultural antibiotics. Mainly used to prevent and control rice blast, including seedling rice blast, leaf blast, ear neck blast, etc., have significant effects, in the effective concentration range of 20-40ppm, safe to use, harmless to crops. The product also has a certain control effect on rice flax leaf spot and sclerotiby, and can also reduce the infection rate of rice stripe disease.
production method
1. plant protein is used as the nutrient source, fermented with actinomycetes, separated from its metabolites, and processed to obtain blast control. The original drug is pyridoxine benzyl benzene sulfonate (containing effective ingredient 90%), and its 2% emulsifiable concentrate is reddish brown transparent liquid, containing effective ingredient ≥ 2.0%.
2. Antibiotic is an antibiotic isolated from the metabolites of actinomycetes (Streptomyces greseochromogenes). It is a base with very complex chemical structure. The production process is made by fermenting, filtering, drying, ball milling and filler from strain culture.
category
Pesticides
toxicity classification
highly toxic
acute toxicity
oral-rat LD50: 16 mg/kg; oral-mouse LD50: 38 mg/kg
flammability hazard characteristics
Combustion produces toxic nitrogen oxide gas
storage and transportation features
The warehouse is ventilated and dry at low temperature; stored and transported separately from food raw materials
fire extinguishing agent
Dry powder, foam, sand
Last Update：2024-04-10 22:29:15
Blaes - Security information
| HazardClass | 6.1(a) |
| PackingGroup | II |
| customs code | 29349990 |
| toxic substance data | 2079-00-7(Hazardous Substances Data) |
| Toxicity | LD50 I .v. in mice: 2.82 mg/kg (Takeuchi) |
Last Update：2024-04-10 22:29:15
Blaes - Reference Information
| toxicity | the original drug has acute oral LD5056.8 mg/kg for male rats, 5055.9 mg/kg for female rats, acute percutaneous LD50>500 mg/kg for rats, and acute inhalation of LC50<0.0032mg/L (4h) for rats. With regard to the acute toxicity of dampenin, there are also reports that soda ash crystallization has an acute oral LD5022.5 mg/kg for mice, which is 158 mg/kg and benzyl sulfamate is 53.5 mg/kg after hydrochloride is made. It is irritating to human eyes and skin. Insight into the eyes can cause conjunctivitis and rash on the skin. Animal experiments showed no carcinogenic, teratogenic and mutagenic effects. Carp LC50>40mg/L (48h). | |
| chemical properties | white needle crystal, m.p.253 ~ 255 ℃,[α]D +108.4o, hydrochloride is white crystal, m.p.202 ~ 204 ℃ (decomposition). It is soluble in acetic acid, hardly soluble in most organic solvents, and has the 12.5% solubility in water. Chemical properties are stable. | |
| use | agricultural antibiotics. It has a systemic therapeutic effect, mainly used to prevent and control rice blast, can inhibit the growth of spores and hyphae of rice-producing bacteria, and can also inhibit a variety of bacteria and other fungi, such as tobacco mosaic disease and rice stripe virus. Rice leaf blast and ear neck blast can be controlled with 2% emulsifiable concentrate 500~1000 times solution. agricultural antibiotics. Mainly used to prevent and control rice blast, including seedling rice blast, leaf blast, ear neck blast, etc., all have significant effects. Within the effective concentration range of 20-40ppm, it is safe to use and harmless to crops. The product also has a certain control effect on rice flax leaf spot and sclerotinia micronae, and can also reduce the infection rate of rice stripe disease. | |
| production method | plant protein is used as nutrient source, fermented with actinomycetes, separated from its metabolites, and processed to obtain blast-killing element. The original drug is benzyl benzene sulfonate (containing effective ingredient 90%), and 2% emulsifiable concentrate is red brown transparent liquid, containing effective ingredient ≥ 2.0%. blast-killing element is an antibiotic isolated from the metabolites of actinomycetes (Streptomyces greseochromogenes). it is a kind of alkali with complex chemical structure. The production process is made by fermentation, filtration, drying, ball milling and filler from strain culture. | |
| category | pesticide | |
| toxicity classification | highly toxic | |
| acute toxicity | oral administration-rat LD50: 16 mg/kg; Oral administration-mouse LD50: 38 mg/kg | |
| flammability hazard characteristics | toxic nitrogen oxide gas generated by combustion | |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Separate storage and transportation from food raw materials | |
| fire extinguishing agent | dry powder, foam, sand | |
| EPA chemical substance information | The information is: ofmpub.epa.gov provides (external link) | |
| toxic substance data | The information is: pubchem.ncbi.nlm.nih.gov Provide (external link) |
Last Update：2024-04-09 20:52:54
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