Boc-D-Arg(pdf)-OH
Fmoc-D-Arg(Pbf)-OH
CAS: 187618-60-6
Molecular Formula: C34H40N4O7S
Boc-D-Arg(pdf)-OH - Names and Identifiers
| Name | Fmoc-D-Arg(Pbf)-OH |
| Synonyms | Boc-D-Arg(pdf)-OH Fmoc-D-Arg(pbf)-OH Fmoc-D-Arg(Pbf)-OH N-ALPHA-FMOC-N-OMEGA-PBF-D-ARGININE N-ALPHA-FMOC-N-OMEGA-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-D-ARGININE N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-NG-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-D-ARGININE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N'-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-D-ARGININE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-OMEGA-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-D-ARGININE N'-[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-arginine 2R)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-{N'-[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]carbamimidamido}pentanoic acid |
| CAS | 187618-60-6 |
| InChI | InChI=1/C24H38N4O7S/c1-13-14(2)19(15(3)16-12-24(7,8)34-18(13)16)36(32,33)28-21(25)26-11-9-10-17(20(29)30)27-22(31)35-23(4,5)6/h17H,9-12H2,1-8H3,(H,27,31)(H,29,30)(H3,25,26,28)/t17-/m1/s1 |
| InChIKey | HNICLNKVURBTKV-MUUNZHRXSA-N |
Boc-D-Arg(pdf)-OH - Physico-chemical Properties
| Molecular Formula | C34H40N4O7S |
| Molar Mass | 648.77 |
| Density | 1.37±0.1 g/cm3(Predicted) |
| Melting Point | 94 to 98℃ |
| Appearance | Crystalline Powder |
| Color | White to Almost white |
| BRN | 9537282 |
| pKa | 3.83±0.21(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Sensitive to heat |
| Refractive Index | 1.581 |
| MDL | MFCD00237010 |
Boc-D-Arg(pdf)-OH - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29350090 |
| Hazard Class | IRRITANT |
Boc-D-Arg(pdf)-OH - Reference Information
| Overview | N'-[(2, 3-dihydro-2, 2,4,6, 7-pentamethylbenzofuran-5-yl) sulfonyl]-N-fluorenomethoxycarbonyl-D-arginine is an amino acid derivative that can be used as a pharmaceutical intermediate. |
| preparation | a6. H-Arg(Pbf)-OH, water 120L and THF were added to the reaction kettle, and the PH = 8.5 was adjusted by Na2CO3. B6. Gradually add Fmoc-Osu (fluorene methoxycarbonyl succinimide), control the temperature 15-20 ℃,PH = 8-9 to finish the reaction of Arg(Pbf), and try to avoid excessive Fmoc-Osu. TLC point plate tracks the reaction, starting from the addition of the Fmoc-Osu, the reaction time is 6 hours. C6. Purification: Extraction with petroleum ether/ethyl acetate (2:1); The aqueous phase was acidified with HCl to pH = 3 and stirred for 2 hours. Acidification temperature 0-10 ℃; Add ethyl acetate to extract the product; Wash with saturated salt water until pH 6; Dry anhydrous sodium sulfate, vacuum filter to remove solids, concentrate filtrate, concentrate under reduced pressure to obtain solids, and vacuum dry to obtain products. The purity of the product is 99.6%, the maximum mono-hybrid 0.09%, and the L-type isomer is 0.15%. |
Last Update：2024-04-10 22:29:15
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