Britannilactone
Britannilactone
CAS: 33627-41-7
Molecular Formula: C17H24O5
Britannilactone - Names and Identifiers
Britannilactone - Physico-chemical Properties
| Molecular Formula | C17H24O5 |
| Molar Mass | 308.37 |
| Density | 1.16 |
| Melting Point | 124.0-126.1 °C |
| Boling Point | 481.7±45.0 °C(Predicted) |
| Specific Rotation(α) | +101.6 (c, 0.264 in CHCl3) |
| Solubility | Ethanol : 50 mg/mL (162.14 mM; Need ultrasonic) |
| Appearance | Powder |
| pKa | 13.71±0.60(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD30207877 |
| In vitro study | Inulicin (1-O-Acetylbritannilactone) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling. Inulicin dose-dependently inhibits vascular endothelial growth factor (VEGF)-induced proliferation, migration, and capillary structure formation of cultured human umbilical vascular endothelial cells (HUVECs). Treatment of A549 NSCLC cells with Inulicin results in cell growth inhibition and Src-FAK in-activation. The potential effect of Inulicin is tested ton Src and FAK phosphorylation in A549 lung cancer cells. Significant high levels of Src and FAK phosphorylations are noticed a in A549 cells, which are both inhibited by treatment of Inulicin (5 μM and 10 μM). Src and FAK are both important for cancer cell proliferation. Thus, A549 cell growth, tested by MTT assay and clonogenicity assay,is remarkably inhibited by corresponding Inulicin treatment. The anti-A549 cell growth activity of Inulicin is again dose-dependent. Inulicin (1-O-Acetylbritannilactone) isolated from Inula britannica-F. , inhibits inflammatory responses in vascular smooth muscle cells (VSMCs). Inulicin (5, 10, 20 μM) has several concentration dependent effects, including inhibition of lipopolysaccharide (LPS)-induced PGE 2 production and COX-2 expression, and blockade of NF-κB activation and translocation. In addition, Inulicin directly inhibits the binding of active NF-κB to specific DNA cis-element. |
| In vivo study | Administration of a single dose of Inulicin (1-O-Acetylbritannilactone; 12 mg/kg/day) remarkably suppresses growth of A549 xenografts in nude mice. In vivo microvessels formation and Src activation are also significantly inhibited in Inulicin-treated xenograft tumors. To investigate the potential activity of Inulicin in vivo, a nude mice xenograft model is applied. A single dose of Inulicin (12 mg/kg/day, i.p.) dramatically inhibits the growth of A549 xenografts in nude mice. Further, the weights of Inulicin-treated tumors are remarkably lighter than that of vehicle-treated tumors. Notably, Inulicin administration does not affect mice body weights. |
Britannilactone - Reference
| Reference Show more | 1. [IF=6.762] Caiping Tian et al."Multiplexed Thiol Reactivity Profiling for Target Discovery of Electrophilic Natural Products."Cell Chem Biol. 2017 Nov;24:1416 |
Britannilactone - Reference Information
| biological activity | inulilin (1-o-ac etyl Britan nactione) is an active compound isolated from Inula Brita Nica L. Inulilin (1-o-ac etyl Britan nilactone) inhibits VEGF-mediated activation of Src and FAK. Inulilin (1-o-ac etyl Britan nilactone) also inhibits LPS-induced PGE2 production and COX-2 expression, as well as inhibiting NF-κB activation and translocation. |
Last Update：2024-04-09 21:32:09
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Product Name: inulicin Visit Supplier Webpage Request for quotationCAS: 33627-41-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Britannilactone Visit Supplier Webpage Request for quotationCAS: 33627-41-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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