Bromo(3,5-difluorobenzyl)zinc
3,5-Difluorobenzylzinc bromide
CAS: 308796-30-7
Molecular Formula: C7H5BrF2Zn
Bromo(3,5-difluorobenzyl)zinc - Names and Identifiers
Bromo(3,5-difluorobenzyl)zinc - Physico-chemical Properties
| Molecular Formula | C7H5BrF2Zn |
| Molar Mass | 272.41 |
| Density | 0.982g/mLat 25°C |
| Flash Point | 1°F |
| Storage Condition | 2-8°C |
Bromo(3,5-difluorobenzyl)zinc - Risk and Safety
| Risk Codes | R19 - May form explosive peroxides R22 - Harmful if swallowed R36/38 - Irritating to eyes and skin. R40 - Limited evidence of a carcinogenic effect R36/37 - Irritating to eyes and respiratory system. R14 - Reacts violently with water R11 - Highly Flammable |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33 - Take precautionary measures against static discharges. S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2056 3/PG 2 |
| WGK Germany | 1 |
| Hazard Note | Flammable |
Bromo(3,5-difluorobenzyl)zinc - Introduction
3,5-Difluorobenzylzine bromide (3,5-Difluorobenzylzine bromide) is an organic compound with the chemical formula C7H4BrF2Zn. It is a colorless to pale yellow liquid with a special odor.
This compound is mainly used as a strong base reagent and an organic zinc reagent in organic synthesis reactions. It can participate in alkylation reaction, electrophilic substitution reaction and reduction reaction of tertiary carbon center. It is also commonly used in the construction of carbon-carbon bond reaction, such as Cross-Coupling reaction and Suzuki-Miyaura reaction.
3,5-Difluorobenzylzinc bromide can be prepared by reacting 3,5-difluorobenzyl bromide with zinc powder in an organic solvent (such as dimethylformamide, DMF). Generally, the reaction will be carried out at a low temperature to ensure the purity of the product.
Regarding safety information, 3,5-Difluorobenzylzinc bromide should be stored in a dry place and avoid contact with water, acid and oxygen. It is irritating and corrosive and should be handled properly with personal protective equipment such as gloves, glasses and lab clothes. Be careful to avoid inhalation, skin contact and ingestion during use. If discomfort occurs, seek medical attention immediately. Operate under ventilated conditions if required. During handling and disposal, local safe operating procedures shall be observed.
This compound is mainly used as a strong base reagent and an organic zinc reagent in organic synthesis reactions. It can participate in alkylation reaction, electrophilic substitution reaction and reduction reaction of tertiary carbon center. It is also commonly used in the construction of carbon-carbon bond reaction, such as Cross-Coupling reaction and Suzuki-Miyaura reaction.
3,5-Difluorobenzylzinc bromide can be prepared by reacting 3,5-difluorobenzyl bromide with zinc powder in an organic solvent (such as dimethylformamide, DMF). Generally, the reaction will be carried out at a low temperature to ensure the purity of the product.
Regarding safety information, 3,5-Difluorobenzylzinc bromide should be stored in a dry place and avoid contact with water, acid and oxygen. It is irritating and corrosive and should be handled properly with personal protective equipment such as gloves, glasses and lab clothes. Be careful to avoid inhalation, skin contact and ingestion during use. If discomfort occurs, seek medical attention immediately. Operate under ventilated conditions if required. During handling and disposal, local safe operating procedures shall be observed.
Last Update：2024-04-10 22:29:15
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