Bromobenzene
Bromobenzene
CAS: 108-86-1
Molecular Formula: C6H5Br
Bromobenzene - Names and Identifiers
| Name | Bromobenzene |
| Synonyms | Brombenzol NCI-C55492 Bromobenzol bromo-benzen Bromobenzene Phenylbromide PHENYL BROMIDE 1-Bromobenzene Benzene,bromo- MONOBROMOBENZENE |
| CAS | 108-86-1 |
| EINECS | 203-623-8 |
| InChI | InChI=1/C6H5Br/c7-6-4-2-1-3-5-6/h1-5H |
| InChIKey | QARVLSVVCXYDNA-UHFFFAOYSA-N |
Bromobenzene - Physico-chemical Properties
| Molecular Formula | C6H5Br |
| Molar Mass | 157.01 |
| Density | 1.491g/mLat 25°C(lit.) |
| Melting Point | -31 °C |
| Boling Point | 156°C(lit.) |
| Flash Point | 124°F |
| Water Solubility | insoluble. |
| Solubility | Miscible with diethyl ether, alcohol, carbon tetrachloride, chloroform and benzene. |
| Vapor Presure | 10 mm Hg ( 40 °C) |
| Vapor Density | 5.41 (vs air) |
| Appearance | Liquid |
| Color | Clear colorless to faintly yellow |
| Odor | Pleasant. |
| Merck | 14,1406 |
| BRN | 1236661 |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Explosive Limit | 0.5-2.5%(V) |
| Refractive Index | n20/D 1.559(lit.) |
| Physical and Chemical Properties | Colorless oily liquid. melting point -31 ℃ boiling point 156 ℃ relative density 1.49 refractive index 1.5590 solubility insoluble in water, soluble in benzene, alcohol, ether, chlorobenzene and other organic solvents. |
| Use | For the synthesis of pharmaceuticals, pesticides, dyes, etc |
Bromobenzene - Risk and Safety
| Risk Codes | R10 - Flammable R38 - Irritating to the skin R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2514 3/PG 3 |
| WGK Germany | 2 |
| RTECS | CY9000000 |
| TSCA | Yes |
| HS Code | 2903 99 80 |
| Hazard Class | 3 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 2383 mg/kg |
Bromobenzene - Nature
Open Data Verified Data
colorless oily liquid, boiling point 156 °c. Melting Point -31 °c. The relative density was 1. 49. Refractive index 5590. Insoluble in water, soluble in benzene, alcohol, ether, chlorobenzene and other organic solvents.
Last Update：2024-01-02 23:10:35
Bromobenzene - Preparation Method
Open Data Verified Data
from the role of benzene and bromine, the first iron powder and benzene into the reactor, slowly adding bromine under stirring, in 70~80 ℃ heat preservation reaction th, the obtained crude product was washed with water and 5% sodium hydroxide solution, left to stand and layered, distilled, dried, filtered, and then cut at 155-157 ° C. By fractionation to obtain a finished product.
Last Update：2022-01-01 10:40:27
Bromobenzene - Use
Open Data Verified Data
raw materials for organic synthesis. Pharmaceutical intermediates.
Last Update：2022-01-01 10:40:27
Bromobenzene - Safety
Open Data Verified Data
- on the skin, mucous membrane stimulation than chlorobenzene strong, narcotic, can make the central nervous system poisoning. Rat oral LD50 500mg/kg. See chlorobenzene. The operator should wear protective gear.
- This product is flammable, should be stored in a cool and ventilated warehouse, away from the heat source, no open flame, should be stored separately from the oxidant, light and light when handling, keep the package intact. According to the provisions of flammable materials storage and transportation.
Last Update：2022-01-01 10:40:28
Bromobenzene - Protective and Antioxidant Effects of Umbrella Water Extract on Liver Injury in Bromobenzene Mice
from HowNet
Author:
Summary:
Objective To investigate the protective effect and antioxidant effect of two kinds of extracts (F Ⅰ,F) on the hepatotoxicity of bromobenzene. Methods Mice were administered for 7 days to prevent ig, and bromobenzene (3 mmol kg-1) was given again for 8 hours. Plasma ALT, liver homogenate MDA and T-SOD were used as indicators of bromobenzene-induced liver injury to observe the effect of water roxa extract. In addition, aged mice were continuously treated with ig for 14 days, and red blood cell superoxide dismutase (SOD), plasma vitamin C and T-AOC were used as antioxidant indexes to observe the anti-free radical effect of water roxa extract. Results F Ⅰ can significantly reduce ALT activity in plasma and increase MDA content in liver of mice with bromobenzene-induced liver injury, while F can reduce MDA content in liver homogenate. Both F Ⅰ and F can significantly increase erythrocyte SOD activity and plasma vitamin C content in aged mice, while F Ⅰ can improve the total oxidation capacity of plasma. Conclusion Both extracts F Ⅰ and F can improve the anti-free radical ability of aged mice, and the extract (especially F Ⅰ) has protective effect on bromobenzene liver injury.
keywords:
water umbrella extract bromobenzene liver injury antioxidant effect
DOI:
10.3321/j.issn:1001-1978.2004.11.007
cited:
Year:
2004
Last Update：2023-08-16 23:40:12
Bromobenzene - Mechanism of sodium ferulate against experimental liver damage of bromobenzene
from HowNet
Author:
Summary:
The effective effect of sodium ferulate (SF) on bromobenzene (BB) liver damage was observed. The results showed that SALT, liver homogenate MDA and liver microsomal cytochrome P-450 enzyme activities were increased during BB liver damage, while liver microsomal and mitochondrial membrane fluidity was also increased. SF100mg/kg oral administration can significantly reduce the increase of the above indexes caused by BB, and restore the fluidity of liver plastoma and mitochondrial membrane to normal, suggesting that SF has a protective effect on BB liver damage, and its mechanism may be related to anti-lipid peroxidation, stabilizing cell membrane and reducing liver drug metabolism enzyme activity.
keywords:
sodium ferulate bromobenzene angelica liver damage "https://xueshu.baidu.com/s?wd=保护作用&tn=SE_baiduxueshu_c1gjeupa&ie=utf-8" target = "_blank"> protection
DOI:
CNKI:SUN:ZGYX. 0.1995-10-007
cited:
Year:
1995
Last Update：2023-08-16 23:40:12
Bromobenzene - Reference Information
| Henry's Law Constant | 2.47 at 25 °C (gas stripping-GC, Shiu and Mackay, 1997) |
| LogP | 3.14 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| uses | used as solvents, automotive fuels, raw materials for organic synthesis, pharmaceutical intermediates, etc. used in the synthesis of pharmaceuticals, pesticides, dyes, etc. bromobenzene is the raw material of fine chemicals, but also the basic raw material for the preparation of pesticides. raw materials for organic synthesis. Pharmaceutical intermediates. used as a solvent, analytical reagent, organic synthesis, etc. |
| production method | from the reaction of benzene and bromine. Firstly, iron powder and benzene were added into the reactor, and bromine was slowly added under stirring. After addition, the reaction was maintained at 70-80 ℃ for 1H, and the crude product was washed with water and 5% sodium hydroxide solution, then allowed to stand for stratification, distilled, drying, filtration, and finally often pressure fractionation, take 155-157 deg C fraction and the product. The preparation method is to use benzene and bromine reaction, using iron powder as catalyst for bromination, after adding bromine in 70~80 ℃ heat preservation reaction for 1H, then washed with water, dried, the product was obtained by distillation. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 2699 mg/kg; Oral-mouse LD50: 2700 mg/kg |
| explosive hazard characteristics | explosive when mixed with air |
| flammability hazard characteristics | flammable in open flame, high temperature, strong oxidant; toxic bromide smoke from combustion |
| storage and transportation characteristics | The package is complete, light, light; The warehouse is ventilated, away from open flame, high temperature, separate from oxidant |
| fire extinguishing agent | foam, carbon dioxide, dry powder, sand, water mist |
| Occupational Standard | TWA 3 mg/m3; Tel 6 mg/m3 |
| spontaneous combustion temperature | 565°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-28 11:18:10
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