Bromodiphenylmethane
Bromodiphenylmethane
CAS: 776-74-9
Molecular Formula: C13H11Br
Bromodiphenylmethane - Names and Identifiers
| Name | Bromodiphenylmethane |
| Synonyms | BENZHYDRYL BROMIDE Benzhydryl bromide DIPHENYLBROMOMETHANE Bromodiphenylmethane BROMODIPHENYLMETHANE diphenylbromomethane DIPHENYLMETHYL BROMIDE Diphenylmethyl bromide α-Bromodiphenylmethane 1-benzyl-2-bromobenzene Methane, bromodiphenyl- Diphenylmethyl bromide) ALPHA-BROMODIPHENYLMETHANE [Bromo(phenyl)methyl]benzene 1,1'(Bromomethylene)bisbenzene 1,1'(Bromomethylene)bisbenzene 1,1'-(bromomethylene)bis-benzen 1,1'-(bromomethylene)bis-benzen 1,1'-(bromomethanediyl)dibenzene Benzhydryl bromide, (Bromodiphenylmathane 9,10-Dihydro-4H-Benzo[4,5] Cyclohepta[1,2-B] Thiophene |
| CAS | 776-74-9 |
| EINECS | 212-279-8 |
| InChI | InChI=1/C12H10.CH3Br/c1-3-7-11(8-4-1)12-9-5-2-6-10-12;1-2/h1-10H;1H3 |
Bromodiphenylmethane - Physico-chemical Properties
| Molecular Formula | C13H11Br |
| Molar Mass | 247.13 |
| Density | 0,9 g/cm3 |
| Melting Point | 35-39°C(lit.) |
| Boling Point | 184°C20mm Hg(lit.) |
| Flash Point | >230°F |
| Water Solubility | Insoluble |
| Solubility | 0.45g/l |
| Vapor Presure | 0.000358mmHg at 25°C |
| Appearance | powder to lump to clear liquid |
| Color | White to cream to yellow to orange to brown crystals or fused solid |
| BRN | 638544 |
| PH | 2 (H2O, 20℃)(saturated aqueous solution) |
| Storage Condition | Store below +30°C. |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.6290 (estimate) |
| Physical and Chemical Properties | Melting point 47. Boiling point of 184 deg C (2.67kPa),150-155 deg C (0.267kPa). |
Bromodiphenylmethane - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R34 - Causes burns R37 - Irritating to the respiratory system |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1770 8/PG 2 |
| WGK Germany | 3 |
| RTECS | PA5350000 |
| FLUKA BRAND F CODES | 19-21 |
| TSCA | Yes |
| HS Code | 29036990 |
| Hazard Class | 8 |
| Packing Group | II |
Bromodiphenylmethane - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | diphenylbromomethane is an intermediate for the preparation of Modafinil (I). Modafinil is the common name for 2-(diphenylmethylsulfinyl) acetamide. Modafinil, a new type of refreshing drug for the central nervous system, developed by French Lafon company, was first launched in France in 1994, it is mainly used for the treatment of narcolepsy and spontaneous hypersomnia. |
| Use | diphenylbromomethane is an intermediate for the preparation of Modafinil (Modafinil,I). Modafinil is the common name for 2-(diphenylmethylsulfinyl) acetamide. Modafinil, a new type of refreshing drug for the central nervous system, developed by French Lafon company, was first launched in France in 1994, it is mainly used for the treatment of narcolepsy and spontaneous hypersomnia. diphenylmethyl bromide is used as a reagent for the synthesis of O-(triazolyl) methyl carbamate and as a novel and effective fatty acid amide hydrolase (FAAH) inhibitor. pharmaceutical intermediates. With anhydrous piperazine, propylene chloride condensation available long-acting multi-functional vasoconstrictor antagonist cinnamizine. |
| preparation | add 33.6g(0.2mol) of diphenylmethane, 8g(0.2mol) of sodium hydroxide, heat to an internal temperature of 95-105 °c. 33.6 (0.21mol) of bromine was slowly added dropwise, and the addition was completed, and the temperature was maintained at 100-110 ° C. For 3 hours. After cooling to room temperature, add 150ml of dichloromethane, mix well, wash with 5% sodium bicarbonate solution, then wash with water until the aqueous layer is neutral, dry the organic layer with anhydrous sodium sulfate, and recover dichloromethane under reduced pressure, the oily product, diphenylmethyl bromide, was poured into a brown bottle and sealed for storage. Yield: 92.8%. |
| production method | diphenylmethane is heated under illumination, Dropwise added with bromine, and kept at 130 ℃ for 1H to obtain brominated diphenylmethane. |
| category | corrosive article |
| flammability hazard characteristics | flammable; Toxic hydrogen bromide gas |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant |
| extinguishing agent | dry powder, carbon dioxide |
Last Update：2024-04-09 02:00:11
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