Bromopropane

Bromopropane - Names and Identifiers

Name	1-Bromopropane
Synonyms	n-propyl Brompropan Bromopropane 1-Brompropan bromo propane 1-bromo-propan 1-Bromopropane Propyl bromide 1,3-Br-propane N-bromopropane n-propylbromide n-Propyl bromide Bromopropane, 1-
CAS	106-94-5
EINECS	203-445-0
InChI	InChI=1/C3H7Br/c1-2-3-4/h2-3H2,1H3

Bromopropane - Physico-chemical Properties

Molecular Formula	C3H7Br
Molar Mass	122.99
Density	1.354g/mLat 25°C(lit.)
Melting Point	-110 °C
Boling Point	71°C(lit.)
Flash Point	72°F
Water Solubility	2.5 g/L (20 ºC)
Solubility	Soluble in acetone, ethanol, ether, benzene, chloroform, carbon tetrachloride
Vapor Presure	146 mm Hg ( 20 °C)
Vapor Density	4.3 (vs air)
Appearance	clear liquid
Color	Colorless to Almost colorless
Exposure Limit	ACGIH: TWA 0.1 ppm
Merck	14,7845
BRN	505936
Storage Condition	Store below +30°C.
Stability	Stability Flammable - note low flash point. Incompatible with strong oxidizing agents, strong bases.
Sensitive	Light Sensitive
Explosive Limit	3.4-9.1%(V)
Refractive Index	n20/D 1.434(lit.)
Physical and Chemical Properties	Melting Point:-110 ℃ Boiling Point: 71 ℃ flash point: 26 ℃ relative density (d204):1.343-1.355 refractive index (n20D):1.433-1.436
Use	For the synthesis of medicines, pesticides, dyes, spices, etc

Bromopropane - Risk and Safety

Risk Codes	R60 - May impair fertility R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R48/20 - R63 - Possible risk of harm to the unborn child R67 - Vapors may cause drowsiness and dizziness
Safety Description	S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2344 3/PG 2
WGK Germany	2
RTECS	TX4110000
FLUKA BRAND F CODES	8
TSCA	Yes
HS Code	29033036
Hazard Class	3
Packing Group	II
Toxicity	LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rat > 2000 mg/kg

Bromopropane - Nature

Open Data Verified Data

colorless flammable liquid. The relative density is 1. 3537(20 ℃). Melting Point -110 °c. Boiling point 71. Refractive index 434. Flash point 25 °c. It is slightly soluble in water and miscible with alcohol and ether.

Last Update：2024-01-02 23:10:35

Bromopropane - Preparation Method

Open Data Verified Data

hydrobromic acid method
sodium bromide method
bromination method

Last Update：2022-01-01 10:14:32

Bromopropane - Use

Open Data Verified Data

It is used in the manufacture of medicines, pesticides, dyes, spices, etc.; It is also used as a raw material of Grignard reagent.

Last Update：2022-01-01 10:14:31

Bromopropane - Safety

Open Data Verified Data

toxicity is similar to that of bromoethane, and exposure of animals to anesthetic concentrations can cause lung and liver damage.
250kg iron barrel, or glass bottle outside the wooden box or calcium plastic box reinforcement, lining bedding. Store in a cool, ventilated warehouse. Keep away from the fire, heat source, and Isolation storage and transportation with oxidant. Avoid sun exposure.

Last Update：2022-01-01 10:14:32

Bromopropane - Reference Information

Henry's Law Constant	7.3*10-3 atm-m3/mol (estimated)
LogP	2.1
(IARC) carcinogen classification	2B (Vol. 115) 2018
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Introduction	n-propyl bromide is a colorless transparent liquid, is a kind of industrial chemical products. 1-bromopropane is a colorless or light yellow transparent liquid, neutral or slightly acidic, sensitive to light, M. P.-110 ℃, B. P. 71 ℃, the relative density of 1.357(20 ℃),n20D is 1.4341, can be mixed with alcohol, ether in any proportion, slightly soluble in water.
Application	n-propyl bromide can be used in the manufacture of medicines, pesticides, dyes, spices, etc, it is also used as a Grignard reagent raw material and an alkylating agent for aromatic compounds, an intermediate for the drug propylthiamine, and probenecid.
preparation	hydrobromic acid was added to concentrated sulfuric acid, followed by addition of N-propanol and heating under reflux for 0.5h. All of the generated bromopropane was distilled off at 70-75 °c, then washed with concentrated hydrochloric acid and neutralized to pH 7 with sodium carbonate. It was dried over anhydrous sodium sulfate, filtered, and the filtrate was Distilled. The 69-74 ° C. Fraction was collected to obtain bromopropane.
Use	1-bromopropane as a raw material for organic synthesis, used in the synthesis of organic phosphorus insecticide, propylsulphur phosphorus, propylphosphine bromide, etc., can also be used in medicine, dyes, perfume industry, as well as Grignard reagent raw materials. It is used in the manufacture of medicines, pesticides, dyes, spices, etc. It is also used as the raw material of Grignard reagent, the drug propylthiamine, and the intermediate of probenecid. used in organic synthesis and pharmaceutical industry 1-bromopropane as a raw material for organic synthesis, it is used in the synthesis of organophosphorus insecticides and acaricides, such as sulfur, phosphorus, can also be used in medicine, dyes, spices industry, and as raw materials for the synthesis of Grignard reagents for medicine, pesticides, dyes, spices and other organic synthesis and pharmaceutical industry for medicine, pesticides, dyes, it is also used as a raw material of Grignard reagent, a drug propylthiamine, and an intermediate of probenecid.
production method	(1) from N-propanol and hydrobromic acid reaction. Hydrobromic acid was added to concentrated sulfuric acid, then n-propanol was added, and the mixture was heated under reflux for 0.5h. All of the generated bromopropane was distilled off at 70-75 °c, then washed with concentrated hydrochloric acid and neutralized to pH 7 with sodium carbonate. It was dried over anhydrous sodium sulfate, filtered, and the filtrate was Distilled. The 69-74 ° C. Fraction was collected to obtain bromopropane. (2) from N-propanol and sodium bromide reaction. N-propanol, water and sodium bromide were heated to reflux, and sulfuric acid was added dropwise at a temperature of 69-72 ° C. After addition, reflux was continued for 2 hours. The distillate at 68-100 °c was collected by distillation, washed with sodium carbonate solution until neutral, and then distilled to collect the distillate at 68-76 °c, namely bromopropane. In addition, n-propanol can also be reacted with bromine in the presence of red phosphorus to produce bromopropane. There are two main methods for preparing bromopropane. (1) from n-Propyl alcohol and hydrobromic acid in the presence of sulfuric acid derived from the role. CH3CH2CH2OH[HBr]→ [H2SO4]CH3CH2CH2Br hydrobromic acid was added to concentrated sulfuric acid, then n-propanol was added, and the mixture was heated to reflux for 0.5h. The generated bromopropane was distilled off at 70-75 ℃, and then washed with concentrated hydrochloric acid, then, the mixture was neutralized with sodium carbonate to pH = 7, dried over anhydrous sodium sulfate, filtered, and the filtrate was Distilled. The 69-74 ° C. Fraction was collected to obtain bromopropane. (2) from N-propanol and sodium bromide reaction. CH3CH2CH2OH[NaBr]→[H2SO4]CH3CH2CH2Br N-propanol, water and sodium bromide were heated to reflux, and sulfuric acid was added dropwise at 69~72 °c for 2H. Distillate at 68~100 °c was collected by distillation, washing with sodium carbonate solution until neutral, and then distillation, 68~76 deg C distillate is collected as bromopropane.
category	flammable liquid
toxicity grade	poisoning
Acute toxicity	oral-rat LD50: 4000 mg/kg; Intraperitoneal-mouse LD50: 2530 mg/kg
explosive hazard characteristics	explosive when mixed with air
flammability hazard characteristics	in case of fire, high temperature, oxidant flammable; toxic bromide smoke from combustion
storage and transportation characteristics	The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant
fire extinguishing agent	water, dry powder, carbon dioxide, foam
spontaneous combustion temperature	914 ° F.
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)