Buparvaquone
Buparvaquone
CAS: 88426-33-9
Molecular Formula: C21H26O3
Buparvaquone - Names and Identifiers
| Name | Buparvaquone |
| Synonyms | BW-720C CS-1178 butalex Buparvaquone Buparvaquone-d4 2-((4-tert-butylcyclohexyl)methyl)-3-hydroxy-1,4-naphthoquinone 2-((4-tert-butylcyclohexyl)Methyl)-3-hydroxynaphthalene-1,4-dione 2-[(4-tert-butylcyclohexyl)methyl]-3-hydroxynaphthalene-1,4-dione 3-[(4-tert-butylcyclohexyl)methyl]-4-hydroxynaphthalene-1,2-dione 2-((4-(1,1-dimethylethyl)cyclohexyl)methyl)-3-hydroxy-4-naphthalenedione 2-[[4-(1,1-dimethylethyl)cyclohexyl]methyl]-3-hydroxy-1,4-naphthalenedione |
| CAS | 88426-33-9 |
| EINECS | 618-162-1 |
| InChI | InChI=1/C21H26O3/c1-21(2,3)14-10-8-13(9-11-14)12-17-18(22)15-6-4-5-7-16(15)19(23)20(17)24/h4-7,13-14,24H,8-12H2,1-3H3 |
Buparvaquone - Physico-chemical Properties
| Molecular Formula | C21H26O3 |
| Molar Mass | 326.43 |
| Density | 1.158±0.06 g/cm3(Predicted) |
| Melting Point | 178-184°C |
| Boling Point | 460.7±45.0 °C(Predicted) |
| Flash Point | 246.536°C |
| Solubility | DMSO: soluble |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | powder |
| Color | Yellow |
| pKa | 5.04±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.574 |
| In vitro study | In 4-day proliferation assays, buparvaquone efficiently inhibits N. caninum tachyzoite replication(IC 50 =4.9 nM; IC 100 =100 nM). Buparvaquone is significantly selective against L. (L.) infantum chagasi intracellular amastigotes, with an IC 50 value of 1.5 μM. Other cutaneous species are also susceptible to buparvaquone, with IC 50 values in the range 1-4 μM. |
| In vivo study | Buparvaquone has a long plasma half-life (at least 7 days) and a low toxic effect (LD50 greater than 8000 mg/kg orally in rats). |
Buparvaquone - Risk and Safety
| WGK Germany | 3 |
| RTECS | QJ5766600 |
| Toxicity | LD50 orally in rats: >2 g/kg (Hudson) |
Buparvaquone - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.063 ml | 15.317 ml | 30.634 ml |
| 5 mM | 0.613 ml | 3.063 ml | 6.127 ml |
| 10 mM | 0.306 ml | 1.532 ml | 3.063 ml |
| 5 mM | 0.061 ml | 0.306 ml | 0.613 ml |
Last Update：2024-01-02 23:10:35
Buparvaquone - Reference Information
| Overview | bopavaquone is named Buparvaquone and chemical name is 2-[(4-tert-butylcyclohexyl) methyl] -3-hydroxy-1, 4-naphthalenedione. Quinone compound is a kind of aromatic organic compounds containing two double bonds of six carbon ring diketone structure, widely exists in nature, many important active ingredients of traditional Chinese medicine contains quinone compounds, many quinone compounds have antibacterial, antiviral or antitumor activity. |
| Usage | the application of budafaxone can be used for the treatment of bovine pyroliasis, and is currently the most effective drug for the treatment of bovine pyroliasis. |
| biological activity | Buparvaquone (buttex) is a second-generation hydroxynaphthoquinone compound with promise for the treatment and prevention of Taylor's disease. |
Last Update：2024-04-10 22:29:15
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