Butylamin
n-Butylamine
CAS: 109-73-9
Molecular Formula: C4H11N
Butylamin - Names and Identifiers
| Name | n-Butylamine |
| Synonyms | MBA tutane Butylamin n-C4H9NH2 Butylamine Butyl amine aminobutane norralamine N-Butylamin 1-Butanamine n-Butilamina n-Butylamine Butylamine, n butan-1-amine 1-Aminobutane Monobutylamine Monobutilamina butan-1-aminium femanumber3130. mono-n-butylamine butan-1-aminium chloride |
| CAS | 109-73-9 |
| EINECS | 203-699-2 |
| InChI | InChI=1/C4H11N/c1-2-3-4-5/h2-5H2,1H3/p+1 |
| InChIKey | HQABUPZFAYXKJW-UHFFFAOYSA-N |
Butylamin - Physico-chemical Properties
| Molecular Formula | C4H11N |
| Molar Mass | 73.14 |
| Density | 0.74g/mLat 25°C(lit.) |
| Melting Point | −49°C(lit.) |
| Boling Point | 78°C(lit.) |
| Flash Point | 30°F |
| JECFA Number | 1582 |
| Water Solubility | MISCIBLE |
| Solubility | water: miscible |
| Vapor Presure | 68 mm Hg ( 20 °C) |
| Vapor Density | 2.5 (vs air) |
| Appearance | Liquid |
| Color | Clear |
| Odor | Fish-like; ammonia-like. |
| Exposure Limit | Ceiling 5 ppm (～15 mg/m3) (ACGIH,MSHA, and OSHA); IDLH 2000 ppm(NIOSH). |
| Merck | 14,1543 |
| BRN | 605269 |
| pKa | 10.77(at 20℃) |
| PH | 12.6 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Incompatible with oxidizing agents, aluminium, copper, copper alloys, acids. Highly flammable. |
| Sensitive | Air Sensitive |
| Explosive Limit | 1.5-9.8%(V) |
| Refractive Index | n20/D 1.401(lit.) |
| Physical and Chemical Properties | Characteristics of colorless, transparent, volatile, irritating ammonia liquid. melting point -50.5 ℃ boiling point 77.8 ℃ relative density 0.7414 refractive index 1.4031 flash point -8 ℃ , ethanol and ether were miscible. |
| Use | Used in the manufacture of pharmaceuticals, pesticides, herbicides, dyes, surfactants, rubber processing aids |
Butylamin - Risk and Safety
| Risk Codes | R11 - Highly Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R35 - Causes severe burns |
| Safety Description | S3 - Keep in a cool place. S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S29 - Do not empty into drains. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1125 3/PG 2 |
| WGK Germany | 1 |
| RTECS | EO2975000 |
| FLUKA BRAND F CODES | 34 |
| TSCA | Yes |
| HS Code | 29211980 |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 orally in rats: 500 mg/kg (Hine) |
Butylamin - Upstream Downstream Industry
| Raw Materials | 1-Butanol Ammonia |
| Downstream Products | Tolbutamide |
Butylamin - Nature
Open Data Verified Data
colorless, transparent, volatile, irritating ammonia liquid. The relative density was 0. 7414. Boiling point 77.8 °c. Melting Point -50.5 °c. Refractive index 4031. Flash point -8 °c. The vapor pressure was 9. 6kPa at 20 ℃. Can be miscible with water, ethanol, ether. The solubility of N-butylamine in water is greater than that of n-butanol.
Last Update：2024-01-02 23:10:35
Butylamin - Preparation Method
Open Data Verified Data
- The butanol hydrogenation method reacts n-butanol vapor with ammonia at 170~200 ℃ under normal pressure by heating a catalyst such as alumina and molybdenum oxide to form a mixed solution of butylamine, the product is then isolated by distillation and may be a final product of mono-, di-and tri-butylamine.
- butanol chlorination and nitridation method ethanol, ammonia and chlorobutane were pressed into the autoclave, stirred and heated to 85~95 ° C. Under the pressure of 54~0.64MPA, the temperature was maintained for 6 hours and cooled. The reaction solution was heated to recover ammonia gas, and then hydrochloric acid was added to adjust the pH value to 3~4, and then ethanol was recovered. Thereafter, liquid alkali was added to the reaction solution to adjust the pH to 11N 12. Finally, the upper layer liquid was separated, and the fraction below 95 ° C. Was cut off by distillation to obtain the crude N-butylamine.
In addition, this product can also be directly prepared by using n-butane chloride in ethanol and ammonium hydroxide.
Last Update：2022-01-01 10:35:09
Butylamin - Use
Open Data Verified Data
This product is a raw material for organic synthesis, used for the preparation of cracking gasoline anti-gelling agent, gasoline antioxidant, rubber polymerization inhibitor, silicone elastomer vulcanizing agent, soap emulsifier, color film developer, and the manufacture of flotation agent, pesticide, herbicides and drugs for the treatment of diabetes, etc.
Last Update：2022-01-01 10:35:09
Butylamin - Safety
Open Data Verified Data
- This product is toxic, strong alkaline and corrosive, and the solution or its vapor strongly irritates the human eye, skin and mucous membranes. Inhalation of large amounts of steam can cause Head Pain, Nausea, severe cases cause pulmonary edema. After contact with the skin, apply a large amount of water to rinse, splash into the eyes, rinse with running water for at least 15 minutes. The inhaler should immediately move to the fresh air and ask a doctor for treatment. Rat oral LD50500mg/kg. The maximum allowable concentration of N-butylamine at the operation site is 1.5 mg/m3. Production equipment should be sealed to prevent running, run, drip and leak. The operation site should be well ventilated, and the operator should wear protective equipment.
- This product is flammable and can form an explosive mixture in contact with air. Packaged in glass bottles, external use of wooden frame fixed, each bottle of 12kg. Watch out for container leaks. Store in a cool and ventilated place, no pyrotechnic, should be stored with the oxidant Isolation.
Last Update：2022-01-01 10:35:10
Butylamin - Reference Information
| FEMA | 3130 | BUTYLAMINE |
| olfactory Threshold | 0.17ppm |
| Henry's Law Constant | 1.76 (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999) |
| LogP | 0 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Application | n-butylamine is an important chemical raw materials and organic synthesis intermediates, widely used in industry, in the fields of agriculture and medicine, for example, in the petroleum industry, it can be used as an anti-gelling agent, an additive, a gasoline antioxidant, a rubber polymerization inhibitor, a silicone elastomer vulcanizing agent, a soap emulsifier, and a pharmaceutical intermediate, for the production of antidiabetic drugs; Pesticide intermediates for the production of carbamate herbicides. |
| health hazard | n-butylamine can be absorbed into the body by inhalation of its vapor, through the skin, and by ingestion. Short-term removal of N-butylamine and its vapors are corrosive to the eyes, skin and respiratory tract. Inhalation of steam may cause pulmonary edema. Effects may be delayed. Medical observation was required. |
| Use | n-butylamine is an intermediate of the fungicide benomyl and also a raw material of n-butyl isocyanate for the production of sulfonylurea herbicides. n-butylamine can be used as an analytical reagent for the detection of cyanide and certain platinum metals, can also be used as emulsifiers and dye intermediates, can also be used in the preparation of pharmaceuticals, pesticides, herbicides, dyes, surfactants, rubber processing aids, etc. pharmaceutical intermediates, for the production of anti-diabetic drugs; Pesticide intermediates, for the production of carbamate herbicides, pesticides; Auxiliary intermediates, for the preparation of cracking gasoline anti-gelling agent, additives, gasoline antioxidant, rubber polymerization inhibitor, silicone elastomer vulcanizing agent, soap emulsifier; N-butylamine neutralization of the acidity of the carrier agent can control the viscosity of alkyd and urea enamel; N-butylamine fatty acid soap is a non-ferrous metal flotation agent; N-butylamine is also a developer for color photographs. U. S. Continental Oil Company uses N-butylamine as a selective solvent for dewaxing and a surface tension inhibitor for demulsification of crude oil. |
| production method | 1. Butanol ammoniation of n-butanol vapor and ammonia in atmospheric pressure, at 170-200 ℃, by heating the catalyst such as alumina, molybdenum oxide reaction to form butylamine mixture, and then the product is separated by distillation, can be a, two, tributylamine finished products. 2. Butanol chlorination and ammonification method ethanol, ammonia water and chlorobutane are added into the autoclave, stirred and heated to 85-95 ℃, with a pressure of about 0.54-0.64MPa, maintained for 6h, cooled and depressurized. The reaction liquid is heated to recover ammonia gas, then hydrochloric acid is added to pH = 3-4, and then ethanol is recovered. Liquid alkali is added to this crude liquid to pH11-12, and the upper liquid is separated, the fractions below 95 ° C. Were collected by distillation to obtain N-butylamine as a finished product with a yield of 50%. Raw material consumption quota: chlorobutane (80%) 2295kg/t, ethanol (95%)840kg/t, ammonia (20%)1500kg/t, liquid ammonia 546kg/t, hydrochloric acid (30%) 1170kg/t, liquid alkali (30%)4515kg/t, Solid alkali 1670kg/t. In addition, this product can also be used directly with n-butane chloride in ethanol and ammonium hydroxide in the role of the system. The preparation method is to pass butanol, ammonia and hydrogen at 170~200 ℃ through a Cu-Ni catalyst with a carrier of clay to obtain a mixture of three amines, namely, n-butylamine, di-n-butylamine and Tri-N-butylamine, the product was subjected to fractional distillation to give products of N-butylamine, di-n-butylamine and Tri-N-butylamine. Reaction equation: C4H9OH + NH3[H2]→ C4H9NH2[C4H9OH]→(C4H9)2NH[C4H9OH]→(C4H9)3N or butanol is used as raw material to form chlorobutane by reaction with hydrogen chloride, the ammonia-containing ethanol, ammonia water and chlorobutane are pressed into the autoclave, stirred and heated to 85~95 ℃, the pressure is 539 ~ 637kPa, maintained for 6h, cooled, the reaction is completed, the reaction solution is heated and ammonia gas is recovered, then hydrochloric acid was added to pH = 3~4, and then ethanol was recovered, The alkali solution was added to this crude liquid to pH = 11 to 12, and the upper layer liquid was separated, and the fraction below 95 ° C. Was collected by distillation as N-butylamine product. Reaction equation: C4H9OH + HCl → C4H9Cl + H2OC4H9Cl + NH3[C2H5OH]→ CH3(CH2)3NH2 + HCl |
| category | flammable liquid |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 366 mg/kg; Oral-mouse LD50: 430 mg/kg |
| stimulation data | eyes-severe at 250 μg/24 h in rabbits; cutaneous-rabbit 500 mg severe |
| explosive hazard characteristics | explosive when mixed with air |
| flammability hazard characteristics | in case of open flame, high temperature, flammable oxidant; Toxic nitrogen oxide smoke generated by combustion; corrosive |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from oxidants and acids |
| extinguishing agent | dry powder, carbon dioxide, foam |
| Occupational Standard | TWA 15 mg/m3 |
| spontaneous combustion temperature | 594 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
| immediate life-and health-threatening concentration | 300 ppm |
Last Update：2024-04-09 21:21:28
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Raw Materials for Butylamin
Downstream Products for Butylamin