C-178
N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide
CAS: 329198-87-0
Molecular Formula: C17H10N2O5
C-178 - Names and Identifiers
C-178 - Physico-chemical Properties
| Molecular Formula | C17H10N2O5 |
| Molar Mass | 322.27 |
| Density | 1.506±0.06 g/cm3(Predicted) |
| Melting Point | >225°C (dec.) |
| Boling Point | 448.3±35.0 °C(Predicted) |
| Solubility | DMSO : 41.67 mg/mL (129.30 mM; Need ultrasonic) |
| Appearance | solid |
| Color | Orange |
| pKa | 11.35±0.43(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| In vitro study | C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. Moreover, C-178 interferes with this process by inhibiting the palmitoylation of STING. C-178 does not appreciably affect STING responses in human cells.C-178 (0-1 μM; 1 hour) alone does not appreciably affect the gene expression profile of BMDMs. In addition, it inhibits the CMA-induced phosphorylation of TBK1.C-178 (1 μM; 1 hour) decreases cdG, dsDNA, CMA and LPS-induced Ifnb1 expression in mouse bone marrow-derived macrophages.C-178 (1 μM; 0.5-4 hours) inhibits the CMA-induced p-TBK1 and sting protein expression as a time-dependent manner in mouse embryonic fibroblasts. Western Blot Analysis Cell Line: Mouse bone marrow-derived macrophages (BMDMs) Concentration: 0 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM Incubation Time: 1 hour Result: Inhibited CMA-induced p-TBK1 expression as a does dependent manner. RT-PCR Cell Line: Mouse bone marrow-derived macrophages (BMDMs) Concentration: 1 μM Incubation Time: 1 hour Result: Downregulated Ifnb1 expression in BMDMs. |
C-178 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.103 ml | 15.515 ml | 31.03 ml |
| 5 mM | 0.621 ml | 3.103 ml | 6.206 ml |
| 10 mM | 0.31 ml | 1.551 ml | 3.103 ml |
| 5 mM | 0.062 ml | 0.31 ml | 0.621 ml |
Last Update：2024-01-02 23:10:35
C-178 - Introduction
N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide is an organic compound with the formula N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide. The following is a description of the properties, uses, formulation and safety information of N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide:
Nature:
N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide is a white solid with a unique chemical structure. Its physical properties such as density and melting point depend on specific structural details, because N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide is not a specific compound name, it is a reference number for a catalyst or ligand.
Use:
Because N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide can be used as a chemical reagent or catalyst, it has a wide range of applications in organic synthesis and chemical reactions. It may be used to catalyze organic reactions, synthesize organic compounds, or as a reactive intermediate.
Preparation Method:
The preparation method of N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide depends on the specific structural details, because this compound is used as a reference number rather than a specific chemical name. It is usually prepared by organic synthesis methods, including chemical reactions, ligand coordination and so on.
Safety Information:
For the security information of N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide, limited information is available for its specific structure. In general, please note the following safety measures:
-Wear appropriate personal protective equipment such as lab gloves, goggles and lab coats when operating N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide.
-Avoid direct contact with N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide, and keep the operation area well ventilated.
-Follow standard operating procedures for the storage and handling of chemicals.
-In the event of accidental exposure to or ingestion of N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide, seek immediate medical assistance and provide accurate information about the compound to your doctor.
It should be noted that since N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide is not a specific compound name, the above information is only a general introduction, it is not specific to a particular compound. Prior to actual use, the compound-specific literature or references should be consulted for more detailed and accurate information.
Nature:
N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide is a white solid with a unique chemical structure. Its physical properties such as density and melting point depend on specific structural details, because N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide is not a specific compound name, it is a reference number for a catalyst or ligand.
Use:
Because N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide can be used as a chemical reagent or catalyst, it has a wide range of applications in organic synthesis and chemical reactions. It may be used to catalyze organic reactions, synthesize organic compounds, or as a reactive intermediate.
Preparation Method:
The preparation method of N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide depends on the specific structural details, because this compound is used as a reference number rather than a specific chemical name. It is usually prepared by organic synthesis methods, including chemical reactions, ligand coordination and so on.
Safety Information:
For the security information of N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide, limited information is available for its specific structure. In general, please note the following safety measures:
-Wear appropriate personal protective equipment such as lab gloves, goggles and lab coats when operating N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide.
-Avoid direct contact with N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide, and keep the operation area well ventilated.
-Follow standard operating procedures for the storage and handling of chemicals.
-In the event of accidental exposure to or ingestion of N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide, seek immediate medical assistance and provide accurate information about the compound to your doctor.
It should be noted that since N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide is not a specific compound name, the above information is only a general introduction, it is not specific to a particular compound. Prior to actual use, the compound-specific literature or references should be consulted for more detailed and accurate information.
Last Update：2024-04-10 22:29:15
Supplier List
Spot supply
Product Name: N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide Visit Supplier Webpage Request for quotationCAS: 329198-87-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide Visit Supplier Webpage Request for quotationCAS: 329198-87-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History