C12189
ungeremine
CAS: 2121-12-2
Molecular Formula: C16H12NO3
C12189 - Names and Identifiers
| Name | ungeremine |
| Synonyms | C12189 Ungerimine ungeremine [1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridinium, 4,5-dihydro-2-hydroxy- |
| CAS | 2121-12-2 |
C12189 - Physico-chemical Properties
| Molecular Formula | C16H12NO3 |
| Molar Mass | 266.275 |
| Density | 1.1727 (rough estimate) |
| Melting Point | 270-272℃ (dec.) |
| Boling Point | 409.48°C (rough estimate) |
| Storage Condition | -20 ℃, sealed, dry |
| Refractive Index | 1.5300 (estimate) |
C12189 - References
| Overview | Lycoris radiata is a perennial herb with stripy or banded leaves, red flowers, some white in color, and thick underground bulbs. Root and bulb can be used as medicine. The underground bulb of the plant Narcissus, as early as in the "Compendium of Materia Medica", has been recorded for the treatment of swollen, healing sores and malignant nuclear and other diseases. Narcissus contains a variety of alkaloids, among which the content of lycorine is the most. Lycorine is a large amount of by-product in the production of poliomyelitis drugs and cyanidamine, which has not been used so far. It has been reported in the data that lycorine has inhibitory effect on human leukemia cells cultured in vitro and has certain curative effect on animal tumors. |
| Related research | The ammonium salt in lycorine is an effective anticancer substance, at the therapeutic dose of 40 mg/kg, the percentage of G1 phase cells decreased, and the G2 M phase cells increased significantly, which blocked the transition of G2 phase cells to G1 phase. After administration of 8~72h, the mitotic index of cancer cells decreased significantly. On the 6th day, the trend was recovering. The inhibitory effect of this drug on cell division in the early and middle stages was strong, especially at 8h after administration, and the effect on the Late and Terminal stages was not obvious. |
Last Update：2024-04-10 22:29:15
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CAS: 2121-12-2
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Mobile: 18021002903
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