C13050

Name	CADP-RIBOSE
Synonyms	C13050 CADP-RIBOSE cADP-Ribose (cADPR) CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE CYCLIC ADENOSINE 5'-DIPHOSPHATE RIBOSE CYCLIC ADP RIBOSE POTENT INTRACELLULAR cyclicadenosinediphosphateribose(cadpr),sodiumsalt N-ALPHA-D-RIOFURANOSYL-P',5''-ESTER ADENOSINE 5'-(TRIHYDROGEN DIPHOSPHATE)
CAS	119340-53-3

Molecular Formula	C15H21N5O13P2
Molar Mass	541.3
Density	2.57±0.1 g/cm3(Predicted)
Boling Point	934.8±75.0 °C(Predicted)
Appearance	Morphological lyophilized powder
pKa	0.97±0.70(Predicted)
Storage Condition	-20°C
Physical and Chemical Properties	Bioactive Cyclic ADP-ribose (cADPR) is an effective calcium mobilization (calcium mobilization) second messenger, which is synthesized from NAD by ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly through Ryanodine receptor-mediated endoplasmic reticulum release and extracellular influx through TRPM2 channel opening.

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3

Raw Materials

Target

Calcium mobilization

TRPM2 channels

Endogenous metabolite

in vitro studies

cADPR (20 nM) elicits a large rapid Ca 2+ release in sea urchin eggs homogenates.

cADPR (100 µM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes.

cADPR (100 µM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture.

In vivo studies

cADPR (100 µM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice.

Last Update：2024-04-10 22:29:15

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C13050

Raw Materials for C13050