C14H15O2NS

C14H15O2NS - Names and Identifiers

Name	Sildenafil Citrate Tablets
Synonyms	Sildenafil Citrate Tablets jinyangjian Jinyang Alkali jinyang base jinyangj Powerful V1 Alcohol soluble alkaline material JinYang C14H15O2NS
EINECS	530-106-7

C14H15O2NS - Physico-chemical Properties

Molecular Formula	C28H38N6O11S
Molar Mass	666.69992
Melting Point	226
Use	Jinyang alkali is the name of the drug. It is yellow or light yellow crystalline powder, odorless, tasteless, soluble in water and alcohol. It is suitable for the treatment of penile erectile dysfunction (ED). It is effective for impotence caused by antidepressants, antipsychotics and antihypertensive drugs, and impotence caused by surgery or trauma.

C14H15O2NS - Pharmacology

During sexual stimulation, parasympathetic nerves, non-adrenergic non-cholinergic nerves (NANC) terminals and vascular endothelial cells release nitric oxide (NO) under the action of nitric oxide synthase (nitricoxide synthase,NOS). In blood vessels, soluble guanylate cyclase (soluble guanlykcyckase,sGC) is usually activated by NO. SGC acts on guanosine triphosphate to produce cyclic guanosine monophosphate cGMP. The cGMP in the cavernous body of the penis produces a strong vasodilatory effect by reducing the concentration of Ca2 in the vascular smooth muscle cells of the cavernous body of the penis, which relaxes the vascular smooth muscle of the cavernous body of the penis, and increases the blood flow in the cavernous body of the penis and induces erection. Gyrine reduces the degree of degradation of cGMP, thereby preserving the role of cGMP in dilating the corpus cavernosum and making the penis erect. In vivo cGMP is deactivated by PDE5 degradation.

Last Update：2023-08-16 23:22:23

C14H15O2NS - Preparation

Jinyang alkali is an important chemical raw material, which has a wide range of uses in organic synthesis, pigments, polymers, fine chemicals, pesticides, dyes and other fields. With the development of the society, the raw material of jinyang alkali has been paid more and more attention by the market and has become an important part of the specific chemical industry.

gold positive alkali raw materials can be obtained from a variety of raw materials, of which the most commonly finished raw materials are lime and sulfuric acid, nitric acid and other oxidants. Lime is the main raw material of gold positive alkali raw material, accounting for 80 ~ 90% of the raw material, composed of organic and inorganic compounds, the main component is Ca0. Sulfuric acid and nitric acid are important auxiliary raw materials of gold positive alkali, accounting for 10 ~ 20% of gold positive alkali raw materials.

The preparation process of gold positive alkali raw materials is mainly calcination, condensation and rolling steps. First, lime, sulfuric acid, nitric acid and other raw materials are mixed and stirred, and then the mixture is calcined at a temperature of 900°C-1000°C to generate a reaction to form a golden positive alkali ortho base; then the positive alkali is put into water to condense, and the condensate is evaporated to obtain a golden positive alkali body; finally, the golden positive alkali crystal is rolled to obtain a golden positive alkali raw material with a required particle size.

Last Update：2023-08-16 23:22:23