Name | Cetostearyl Alcohol |
Synonyms | C1618 LANETTE AOK CETOSTEAROL heptadecan-1-ol CETEARYL ALCOHOL Alkohole, C16-18 Cetearyl alcohol Cetostearyl Alcohol C16-18-Alkylalcohol CETOSTEARYL ALCOHOL Ceto-stearyl alcohol CETYLSTEARYL ALCOHOL CETYL-STEARYL ALCOHOL tetratriacontan-17-ol CETYL ALCOHOL - STEARYL ALCOHOL |
CAS | 67762-27-0 |
EINECS | 267-008-6 |
InChI | InChI=1/C34H70O/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-34(35)32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h34-35H,3-33H2,1-2H3 |
Molecular Formula | C18H38O.C16H34O |
Molar Mass | 512.941 |
Density | 0.8[at 20℃] |
Melting Point | 51 - 53°C |
Boling Point | 330.79℃[at 101 325 Pa] |
Flash Point | 132.853°C |
Water Solubility | 72.197μg/L at 25℃ |
Solubility | Practically insoluble in water, soluble in ethanol (96 per cent) and in light petroleum. When melted, it is miscible with fatty oils, with liquid paraffin and with melted wool fat. |
Vapor Presure | 0.001Pa at 25℃ |
Appearance | Solid |
Color | White to Off-White |
pKa | 15.76[at 20 ℃] |
Storage Condition | Refrigerator |
Refractive Index | 1.46 |
Physical and Chemical Properties | White viscous lotion or yellow viscous lotion, with fine particles, good film formation and high film transparency, can be used for leather finishing to significantly improve and enhance the leather performance, diluted in any proportion, and free of insoluble substances. |
Use | As a leather finishing agent, it can form a film with anionic leather surface, with firm adhesion, difficult delamination, fine lotion particles, good film formation and high film transparency. Used for leather finishing, it can significantly improve and enhance leather performance, and enhance the grade of leather. Its coverage, feel, and gloss indicators reach the R-72 level of C-4/7 in the United States and R-72 in Italy. |
Caution | Sealed and stored in a cool and ventilated place, at room temperature (5-35 ℃), sun and frost proof, non hazardous, with a storage period of 12 months. |
Toxicity | The acute oral toxicity of cetostearyl alcohol was tested in Wistar rats. The LD 50 was greater than 10000 mg/kg bw. |
This product is a mixture of decanol and decanol. It shall contain not less than of decanol (c 1sh 38o) and not less than 90.0% of the sum of decanol (C1SH340) and decanol (C18H3R0).
The melting point of this product (General rule 0612 second method) is 49~56°C.
should not be greater than 1. 0 (General rule 0713).
take this product 20.0g, according to the operation (General 0713), should not be greater than 2 .0.
take 2.0g of this product, add chloroform 25ml, shake to dissolve, operate according to law (General rule 0713), should not be greater than 2.0.
should be 208 to 228 (General 0713).
Mix 20%~30% emulsified paraffin with surfactant, 10%~15% acrylic acid lotion (film forming agent), W-2 film forming agent and other additives evenly.
In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.
clarity and color of ethanol solution take this product 0 .5 0g, add ethanol 20 M l to dissolve, cool, check according to law (General Rule 0 9 0 1 and General Rule 0 9 0 2 ), the solution should be clear and colorless; if it is turbid, it should not be more concentrated compared with No. 1 turbidity standard solution (General rule 090 2 First method).
measured by gas chromatography (General 0521).
chromatographic conditions and system suitability test
with 100%-polydimethylsiloxane as the stationary liquid capillary column, the detector is hydrogen flame ionization detector; Column temperature 205C, injection port temperature 250T:, detector temperature 25(TC; the number of theoretical plates shall not be less than 10 000 based on the calculation of the ten-hexanol peak, and the separation degree of the peaks of ten-hexanol and ten-hexanol shall be in accordance with the regulations.
assay
take 100mg of this product, weigh it accurately, put it in a 100ml measuring flask, add anhydrous ethanol to dissolve and dilute it to the scale, shake it well, 1/^ 1 was injected into the gas chromatograph j, and the chromatogram was recorded. The appropriate amount of the reference substance of hexanol and the reference substance of decanol was accurately weighed, absolute ethanol was added to dissolve to prepare each containing 0. 5mg of mixed solution, shake, the same method of operation, according to the external standard method to calculate the peak area of the content and the sum of the content of the ten alcohol and the eight alcohol, that is.
pharmaceutical excipients, blockers and matrix.
sealed, stored in a cool and dry place.
LogP | 6.73 at 25℃ |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
properties | The alkyl C16-18 alcohol shall be a white granular or flaky solid with a specific odor. Do not dissolve in water, soluble in ethanol, ether, chloroform and other organic solvents, with the general nature of alcohols. |
Source | The Eighty-six alcohol series is prepared by reducing suitable fatty acids from plant or animal sources, it can also be produced directly from hydrocarbons. |
function | lubricant; Emulsifier; Tackifier. This product can be used in cosmetics and topical preparations. In a topical formulation, eighteen-hexanol increases the viscosity of the w/o and o/w emulsions. It stabilizes the emulsion and has a co-emulsifying effect, thereby reducing the amount of surfactant required to form a stable emulsion. Eighty-six alcohols are also used in the preparation of non-aqueous creams and lipsticks. It has been reported that eighty-six alcohols can be used to reduce the release of water-soluble drugs. In combination with a surfactant, it can form emulsions with complex microstructures including liquid crystals, plate-like structures, and gel phases. |
Use | C16-18 alcohol is obtained by esterification, hydrogenation and fractionation of natural oils as raw materials, leather, textile, synthetic detergent and other industries are suitable for all kinds of cosmetics, as a matrix, especially suitable for cream and emulsion; In medicine, can be directly used for W/O emulsifier paste, ointment matrix, etc, hair care, skin care. It is also used as a raw material for Textile Auxiliaries in industry. C16-18 alcohol is an oil and fat chemical raw material, which is mainly composed of C- hexanol and C- hexanol. There are three main ratios of 16-18 alcohols currently on the market: C16:C18 = 7:3, C16:C18 = 3:7 and C16:C18 = 5:5. C16:C18 = 3:7 is the most widely used. |
Application | can be used to prepare a makeup removal mask, using water as solvent, glycerin, cetyl palmitate, PEG-7 olive oil ester, glyceryl coconut Ester, isodecane, polydimethylsiloxane, polysorbate -80, polysorbate -20 as emulsifier, cetostearyl alcohol isonanoate, cetostearyl alcohol polyether -20, cetostearyl alcohol, Glyceryl stearate, cetostearyl alcohol polyether -12 as emollient, phenoxyethanol, hydroxymethyl ester as preservative; Sodium acrylate/sodium acryloyldimethyltaurate copolymer as thickener; purslane extract skin conditioner and flavor preparation. |
safety | C16-18 alcohol is mainly used in topical preparations and topical cosmetics. This product is generally regarded as a non-toxic substances. Although it is essentially non-irritating, allergic reactions have also been reported with respect to sixteen-Eighty-six-alcohol, ten-six-alcohol and ten-eight-alcohol. |