CACCINH-A01 - Names and Identifiers
Name | CaCCinh-A01
|
Synonyms | CACCINH-A01 CaCCinh-A01 TMEM16 BLOCKER I CaCC(inh)-A01, TMEM16 Blocker I. CACC(INH)-A01, TMEM16 BLOCKER I. 6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid Benzo[b]thiophene-3-carboxylic acid, 6-(1,1-dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-
|
CAS | 407587-33-1
|
CACCINH-A01 - Physico-chemical Properties
Molecular Formula | C18H21NO4S
|
Molar Mass | 347.43 |
Density | 1.305±0.06 g/cm3(Predicted) |
Boling Point | 429.7±45.0 °C(Predicted) |
Solubility | Soluble in DMSO |
Appearance | powder |
Color | white to beige |
pKa | 4.49±0.40(Predicted) |
Storage Condition | 2-8°C |
Use | CaCCinh-A01 are inhibitors of TMEM16A and calcium-activated chloride channels (CaCC) with IC50 values of 2.1 and 10 μM, respectively. |
CACCINH-A01 - Risk and Safety
CACCINH-A01 - Preparation solution concentration reference
| 1mg | 5mg | 10mg |
---|
1 mM | 2.878 ml | 14.391 ml | 28.783 ml |
5 mM | 0.576 ml | 2.878 ml | 5.757 ml |
10 mM | 0.288 ml | 1.439 ml | 2.878 ml |
5 mM | 0.058 ml | 0.288 ml | 0.576 ml |
Last Update:2024-01-02 23:10:35
CACCINH-A01 - Reference Information
biological activity | CaCCinh-A01 (TMEM16 Blocker I) is a TMEM16A Blocker with an IC50 value of 2.1 μm. CaCCinh-A01 is also an inhibitor of calcium-activated chloride channel (CaCC) with an IC50 value of approximately 10 μm. |
Target | Value |
TMEM16A
(Cell-free assay)
| 2.1 μM |
CaCC
(Cell-free assay)
| 10 μM |
Last Update:2024-04-09 21:04:16