CALCEINE
Calcein
CAS: 1461-15-0
Molecular Formula: C30H26N2O13
CALCEINE - Names and Identifiers
| Name | Calcein |
| Synonyms | Calcein CALCEIN CALCEINE Oftasceine CALCEIN, INDICATOR FLUORESCEIN COMPLEXON FLUORESCEIN COMPLEXONE FLUORESCEIN-METHYLENE-IMINODIACETIC ACID BIS[N,N-BIS(CARBOXYMETHYL)AMINOMETHYL]FLUORESCEIN FLUORESCEIN-2,7-BIS-METHYLIMINODIACETIC SODIUM SALT 2,2',2'',2'''-[(3',6'-dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-2',7'-diyl)bis(methanediylnitrilo)]tetraacetic acid |
| CAS | 1461-15-0 |
| EINECS | 215-957-1 |
| InChI | InChI=1/C30H26N2O13/c33-21-7-23-19(5-15(21)9-31(11-25(35)36)12-26(37)38)30(18-4-2-1-3-17(18)29(43)45-30)20-6-16(22(34)8-24(20)44-23)10-32(13-27(39)40)14-28(41)42/h1-8,33-34H,9-14H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42) |
CALCEINE - Physico-chemical Properties
| Molecular Formula | C30H26N2O13 |
| Molar Mass | 622.53 |
| Density | 1.4388 (rough estimate) |
| Melting Point | 200 °C |
| Boling Point | 662.7°C (rough estimate) |
| Flash Point | 530°C |
| Water Solubility | insoluble |
| Solubility | H2O: soluble |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Yellow powder |
| Color | Yellow-orange to orange-brown |
| Maximum wavelength(λmax) | ['494nm'] |
| pKa | 6.67(at 25℃) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.5800 (estimate) |
| MDL | MFCD00005049 |
| Use | Determination of calcium, steel, strontium, copper and manganese by complexing indicator |
| In vitro study | Calcein accumulates intracellularly in coelomocytes incubated in coelomic fluid or ISO-EDTA. Coelomocytes incubated in CF show an increase in the calcein fluorescence intensity compared to the control. |
CALCEINE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 32041900 |
CALCEINE - Reference
| Reference Show more | 1. Tian Tao, Fu Qiang, Zhu Jiankui et al. Observation on the Benefit of Erzhi Pill in Treating Zebrafish Osteoporosis Model and the Mechanism of Osteoclast Autophagy [J]. Journal of Nanjing University of Traditional Chinese Medicine 2020 v.36(03):78-83. 2. Lin Ziwei, Yang Fei, Huang Tianyi, et al. Study on the Effect of Paeoniflorin on Osteoblast Apoptosis and Anti-osteoporosis [J]: 426-431. 3. Yan, Xiao-Xiao; Liu, Jing-Quan; Jiang, Shui-Dong; Yang, Bin; Yang, Chun-Sheng: 'Tapered metal microneedles fabricated by the human process of mechanical dicing and electrochemical corrosion for drug delivery', Micro & Nano Letters, 2012, 7, (12), p. 1 4. Yan, Xiao-Xiao, et al. "Fabrication and testing analysis of tapered silicon microneedles for drug delivery applications." Microelectronic engineering 111 (2013): 33-38.https:// doi.org/10.1016/j.mee. 2013.04.039 5. [IF=2.523] Xiao-Xiao Yan et al."Fabrication and testing analysis of tapered silicon microneedles for drug delivery applications."Microelectron Eng. 2013 Nov;111:33 6. [IF=8.694] Zheng Zhang et al."FOS/GOS attenuates high-fat diet induced bone loss via reversing microbiota dysbiosis, high intestinal permeability and systemic inflammation in mice."Metabolism. 2021 Jun;119:154767 7. [IF=7.514] Linlin Fan et al."Stable vesicle self-assembled from phospholipid and mannosylerythritol lipid and its application in encapsulating anthocyanins."Food Chem. 2021 May;344:128649 8. [IF=6.529] Wei-ni Qin et al."The toxicity mechanism of toxic compounds from Euphorbiae pekinensis Radix on zebrafish embryos."Biomed Pharmacother. 2021 Jun;138:111521 9. [IF=4.011] Yang F. et al."Ligustilide, a major bioactive component of Angelica sinensis , promotes bone formation via the GPR30/EGFR pathway."Sci Rep-Uk. 2019 May;9(1):1-10 10. [IF=3.935] Hui Jiang et al."Preparation of covalently bonded liposome capillary column and its application in evaluation of drug membrane permeability."J Pharmaceut Biomed. 2022 Feb;209:114513 |
CALCEINE - Reference Information
| pH indicator color change ph range | Weak green 'uorescence (6.0) to strong green 'uorescence (7.2) |
| biological application | Calcium indicator; fluoride indicator; iron indicator; mercury indicator; detecting nucleic acids,proteins; treating osteoporosis; drug delivery systems |
| main applications | Chemical-mechanical polishing, stabilizing liposomes, cell motility say, detecting nucleic acids, virus, screening safety of gastric mcosa, MDR inhibitors, delivery, imaging atherosclerotic plaque |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | Calcein is a fluorescent dye and self-extinguishing probe, which can be used as an indicator of lipid vesicle leakage, and can also be used as a complexing indicator for EDTA calcium ion titration and fluorescence determination of calcium ions. |
| Use | Complexation indicator is used for the determination of calcium, steel, strontium, copper, manganese, etc. Used for fluorescence determination of calcium, or EDTA titration of calcium in the presence of magnesium. |
Last Update：2024-04-09 21:22:08
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