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CEFPIROME

Cefpirome

CAS: 84957-29-9

Molecular Formula: C22H22N6O5S2

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CEFPIROME - Names and Identifiers

Name Cefpirome
Synonyms CEFPIROME
Cefpirome
CEFPIROME SULPHATE
Cefpirome main-ring
Cefpirome.HCl (Cefpirome)
3-[(2,3-cyclopenteno-1-pyridinium)methyl]-7-[2-syn-methoxyimino-2-(2-aminothiazol-4-yl)acetamido]ceph-3-em-4-carboxylate
(6R,7R)-7-(()-2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido)-8-oxo-3-(2beta-trimethylenpyridinio)methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carboxylat
1-(((6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydro-5H-1-pyridinium hydroxide, inner salt
1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-6,7-dihydro-5H-cyclopenta[b]pyrindinium inner salt
(6S,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(6,7-dihydro-5H-cyclopenta[b]pyridinium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(6R,7R)-7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(6,7-dihydro-5H-cyclopenta[b]pyridinium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(6,7-dihydro-5H-cyclopenta[b]pyridinium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
1-[[(6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-6,7-dihydro-5H-1-pyrindinium hydroxide, inner salt, 72-(Z)-(O-methyloxime)
5H-1-Pyrindinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydro-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-
5H-1-Pyrindinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-5,6,7,8-tetrahydro-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-
CAS 84957-29-9
EINECS 1592732-453-0
InChI InChI=1/C22H22N6O5S2/c1-33-26-15(13-10-35-22(23)24-13)18(29)25-16-19(30)28-17(21(31)32)12(9-34-20(16)28)8-27-7-3-5-11-4-2-6-14(11)27/h3,5,7,10,16,20H,2,4,6,8-9H2,1H3,(H3-,23,24,25,29,31,32)/b26-15-/t16-,20+/m1/s1

CEFPIROME - Physico-chemical Properties

Molecular FormulaC22H22N6O5S2
Molar Mass514.58
Storage Condition2-8°C(protect from light)
Physical and Chemical PropertiesWhite to yellowish white crystalline powder, slightly specific odor. More soluble in water, a few do not dissolve in ethanol or ether. When the pH value is 5~7, it is soluble in water, and its aqueous solution stability can be compared with that of cefotaxime and other third generation cephalosporins. Acute toxicity LD50 mice, rats (g/kg):1.9~2.4,1.9~2.15 intravenous injection; 3.8~4.2,5.8~6.55 intraperitoneal injection. Cefpirome Sulfate: 022H22N6O5S2? H2SO4. [98753-19-6]. Crystallization, melting point 198~202 C (decomposition). [Α] D23-4.7 °(C = 5, water). UV maximum absorption: 265MN (φ21100). Solubility was> 6.5 in buffer at Ph = 50%.

CEFPIROME - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk CodesR36/37/38 - Irritating to eyes, respiratory system and skin.
R42/43 - May cause sensitization by inhalation and skin contact.
Safety DescriptionS22 - Do not breathe dust.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
ToxicityLD50 in mice, rats (g/kg): 1.9-2.4, 1.9-2.15 i.v.; 3.8-4.2, 5.8-6.55 i.p. (Donaubauer, Mayer)

CEFPIROME - Nature

Open Data Verified Data

white to yellowish crystalline powder with slight specific odor. Soluble in water, almost insoluble in ethanol or ether.

Last Update：2024-01-02 23:10:35

CEFPIROME - Preparation Method

Open Data Verified Data

cefotaxime and 2,3 cyclopentenopyridine in the presence of potassium iodide, heated in water, cefpirome. Alternatively, cefpirome is also obtained by converting its side chain to iodide and refluxing 2, 3-cyclopentenopyridine in dichloromethane. Cefpirome was further salified with sulfuric acid to obtain cefpirome sulfate.

Last Update：2022-01-01 08:52:12

CEFPIROME - Use

Open Data Verified Data

cefpirome sulfate is a new type of cephalosporin antibiotics, the drug was successfully developed by the German Hoechst, and in 1992 first in Mexico, Sweden market, trade name Cefrom. Broad antibacterial spectrum, strong antibacterial activity, the antibacterial effect of Staphylococcus aureus and cefotiam the same I Pseudomonas aeruginosa and piperacillin, gentamicin similar. It is stable against β-lactamases, including various plastid-mediated penicillinase and chromosome-mediated cephalosporinase. For sepsis and severe urinary tract infection, respiratory tract infection.

Last Update：2022-01-01 08:52:13
CEFPIROME
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CAS: 84957-29-9
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Cefpirome Visit Supplier Webpage Request for quotation
CAS: 84957-29-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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CEFPIROME
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