CGAMP游离态
c-GpAp
CAS: 849214-04-6
Molecular Formula: C20H24N10O13P2
CGAMP游离态 - Names and Identifiers
| Name | c-GpAp |
| Synonyms | cGAMP c-GpAp C-GPAP di-GAMP di-cGAMP 3'3'-cGAMP cGAMP (Cyclic GMP-AMP 3''-Guanylic acid, adenylyl-(3''?5'')-, cyclic nucleotide 3',3'-Cyclic guanosine monophosphate-adenosine monophosphate |
| CAS | 849214-04-6 |
CGAMP游离态 - Physico-chemical Properties
| Molecular Formula | C20H24N10O13P2 |
| Molar Mass | 674.41 |
| Density | 2.61±0.1 g/cm3(Predicted) |
| Boling Point | 1159.9±75.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| Appearance | Morphological powder |
| Color | white to beige |
| pKa | 0.96±0.70(Predicted) |
| Storage Condition | -20°C |
| Physical and Chemical Properties | Bioactive 3 ',3'-cGAMP (3 ',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates endoplasmic reticulum (ER) endogenous receptor stimulator of interferon genes (STING), thereby inducing antiviral state and type I IFN secretion. |
| In vitro study | cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice. cGAMP directly activates murine and human dendritic cells in vitro. On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF). cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs. |
| In vivo study | cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice. Animal Model: Female C57BL/6 (H-2b) mice 6–8 weeks old Dosage: 5 µg Administration: Nostril mucosal adjuvant Result: Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice. |
CGAMP游离态 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.483 ml | 7.414 ml | 14.828 ml |
| 5 mM | 0.297 ml | 1.483 ml | 2.966 ml |
| 10 mM | 0.148 ml | 0.741 ml | 1.483 ml |
| 5 mM | 0.03 ml | 0.148 ml | 0.297 ml |
Last Update：2024-01-02 23:10:35
CGAMP游离态 - Uses and synthesis methods
Target
Target Value
STING
in vitro studies
cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice.
cGAMP directly activates murine and human dendritic cells in vitro.
On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF).
cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs.
In vivo studies
cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice.
Animal Model: Female C57BL/6 (H-2b) mice 6-8 weeks old
Dosage: 5 µg
Administration: Nostril mucosal adjuvant
Result: Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.
Last Update：2024-04-10 22:29:15
CGAMP游离态 - Introduction
c-GpAp is a chimeric exogenous DNA molecule known as Cyclic adenylyl diphosphate (Cyclic GMP-AMP ammonium salt). Its structure is a cyclic molecule consisting of two guanylic acid (GMP) and two adenylic acid (AMP) units linked by phosphodiester bonds.
c-GpAp can act as an immunomodulator and play an important role in the immune system. It can induce cells to produce interferon beta and other immune cytokines, thereby enhancing the body's anti-viral and anti-tumor immune responses. This makes c-GpAp have potential application value in tumor immunotherapy and immune vaccine research.
The preparation of c-GpAp is generally achieved by chemical synthesis. The specific preparation method includes synthesizing CGAMP molecules by reacting appropriate guanosine and adenosine units under appropriate reaction conditions, and reacting them with ammonium salts to obtain c-GpAp.
c-GpAp need to pay attention to some safety matters during use. It is a chemical substance that can cause irritation to the skin, eyes and respiratory system, so it is necessary to wear appropriate protective equipment during operation, such as laboratory gloves, goggles and masks. At the same time, to avoid its contact with fire and oxidant, so as not to cause fire or explosion. In the process of storage and handling, should be away from high temperature, humidity and fire and other dangerous factors.
Please note that the relevant laboratory safety guidelines and hazardous material handling requirements should be followed for specific laboratory operation and use details.
c-GpAp can act as an immunomodulator and play an important role in the immune system. It can induce cells to produce interferon beta and other immune cytokines, thereby enhancing the body's anti-viral and anti-tumor immune responses. This makes c-GpAp have potential application value in tumor immunotherapy and immune vaccine research.
The preparation of c-GpAp is generally achieved by chemical synthesis. The specific preparation method includes synthesizing CGAMP molecules by reacting appropriate guanosine and adenosine units under appropriate reaction conditions, and reacting them with ammonium salts to obtain c-GpAp.
c-GpAp need to pay attention to some safety matters during use. It is a chemical substance that can cause irritation to the skin, eyes and respiratory system, so it is necessary to wear appropriate protective equipment during operation, such as laboratory gloves, goggles and masks. At the same time, to avoid its contact with fire and oxidant, so as not to cause fire or explosion. In the process of storage and handling, should be away from high temperature, humidity and fire and other dangerous factors.
Please note that the relevant laboratory safety guidelines and hazardous material handling requirements should be followed for specific laboratory operation and use details.
Last Update：2024-04-09 21:11:58
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Spot supply
Product Name: cGAMP Visit Supplier Webpage Request for quotationCAS: 849214-04-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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