CGP71683HCl
CGP71683 hydrochloride
CAS: 192322-50-2
Molecular Formula: C26H30ClN5O2S
CGP71683HCl - Names and Identifiers
CGP71683HCl - Physico-chemical Properties
| Molecular Formula | C26H30ClN5O2S |
| Molar Mass | 512.07 |
| Solubility | DMSO: 120 mg/mL (234.34 mM)Water: 10 mg/mL (19.53 mM)( < 1 mg/ml refers to the product slightly soluble or insoluble) |
| Appearance | solid |
| Color | off-white |
| Storage Condition | Inert atmosphere,2-8°C |
| Use | CGP71683 hydrochloride is a competitive neuropeptide receptor (neuropeptide Y5 receptor) antagonist with a Ki value of 1.3 nM. In cell membrane, it has no obvious effect on Y1 and Y2 receptors (Ki,>4000 nM,200 nM). |
| In vitro study | CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a K i of 1.3 nM, and shows no obvious activity at Y1 receptor (K i , >4000 nM) and Y2 receptor (K i , 200 nM) in cell membranes. |
| In vivo study | CGP71683 (15 nmol/rat, icv, twice daily) shows anorexigenic effect, reducing food intake and bady weight of fed rats. CGP71683 causes 3-times higher serum total T4 and 37% increase in free T4 in the fasted rats than in the fasted controls rats. |
CGP71683HCl - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
CGP71683HCl - Reference
| Reference Show more | 1: Ghahramanian Golzar M, Babri S, Ataie Z, Ebrahimi H, Mirzaie F, Mohaddes G. NPY Receptors Blockade Prevents Anticonvulsant Action of Ghrelin in the Hippocampus of Rat. Adv Pharm Bull. 2013;3(2):265-71. doi: 10.5681/apb.2013.043. Epub 2013 Aug 20. PubMed PMID: 24312846; PubMed Central PMCID: PMC3848244. 2: Li L, Mayer M, Schneider E, Schreiber E, Bernhardt G, Peng S, Buschauer A. Preparation of fluorescent nonpeptidic neuropeptide Y receptor ligands: analogues of the quinazoline-type anti-obesity Y5 antagonist CGP 71683A. Arch Pharm (Weinheim). 2003 Dec;336(12):585-90. PubMed PMID: 14677152. 3: Lecklin A, Lundell I, Paananen L, Wikberg JE, Männistö PT, Larhammar D. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br J Pharmacol. 2002 Apr;135(8):2029-37. PubMed PMID: 11959807; PubMed Central PMCID: PMC1573328. 4: Della Zuana O, Sadlo M, Germain M, Félétou M, Chamorro S, Tisserand F, de Montrion C, Boivin JF, Duhault J, Boutin JA, Levens N. Reduced food intake in response to CGP 71683A may be due to mechanisms other than NPY Y5 receptor blockade. Int J Obes Relat Metab Disord. 2001 Jan;25(1):84-94. PubMed PMID: 11244462. |
CGP71683HCl - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.953 ml | 9.764 ml | 19.529 ml |
| 5 mM | 0.391 ml | 1.953 ml | 3.906 ml |
| 10 mM | 0.195 ml | 0.976 ml | 1.953 ml |
| 5 mM | 0.039 ml | 0.195 ml | 0.391 ml |
Last Update：2024-01-02 23:10:35
CGP71683HCl - Introduction
CGP71683 hydrochloride is a compound with the formula C23H27ClN6O3. It is a white solid powder, soluble in water and organic solvents.
CGP71683 hydrochloride is commonly used as a research tool to study the treatment of diseases such as tumors, cancer and autoimmune diseases. It has been found to have anti-inflammatory, anti-tumor and immunomodulatory activities.
The method for preparing CGP71683 hydrochloride is to first synthesize its intermediate and then react with hydrochloric acid. This method is generally used for laboratory research and preparation, and the specific reaction conditions and Operation steps need to be adjusted according to the actual situation.
Regarding safety information, CGP71683 hydrochloride needs to be handled in accordance with Good Laboratory Practices and pay attention to protective measures. It may be irritating to the eyes, skin and respiratory system, so appropriate personal protective equipment should be worn when handling. In addition, it should be kept away from fire and oxidizing agents and avoid contact with air and moisture. Appropriate regulations and procedures shall be observed during storage and handling. For specific safety operation instructions, please refer to the safety data sheet provided with the product.
CGP71683 hydrochloride is commonly used as a research tool to study the treatment of diseases such as tumors, cancer and autoimmune diseases. It has been found to have anti-inflammatory, anti-tumor and immunomodulatory activities.
The method for preparing CGP71683 hydrochloride is to first synthesize its intermediate and then react with hydrochloric acid. This method is generally used for laboratory research and preparation, and the specific reaction conditions and Operation steps need to be adjusted according to the actual situation.
Regarding safety information, CGP71683 hydrochloride needs to be handled in accordance with Good Laboratory Practices and pay attention to protective measures. It may be irritating to the eyes, skin and respiratory system, so appropriate personal protective equipment should be worn when handling. In addition, it should be kept away from fire and oxidizing agents and avoid contact with air and moisture. Appropriate regulations and procedures shall be observed during storage and handling. For specific safety operation instructions, please refer to the safety data sheet provided with the product.
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: CGP71683 hydrochloride Visit Supplier Webpage Request for quotationCAS: 192322-50-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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