CHEMBRDG-BB 3015435
Isobutyric acid hydrazide
CAS: 3619-17-8
Molecular Formula: C4H10N2O
CHEMBRDG-BB 3015435 - Names and Identifiers
CHEMBRDG-BB 3015435 - Physico-chemical Properties
| Molecular Formula | C4H10N2O |
| Molar Mass | 102.14 |
| Density | 0.976±0.06 g/cm3(Predicted) |
| Melting Point | 97 °C |
| Boling Point | 238.6±9.0 °C(Predicted) |
| Flash Point | 98.1°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.042mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| pKa | 13.46±0.36(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.442 |
CHEMBRDG-BB 3015435 - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN2811 |
| Hazard Class | IRRITANT |
CHEMBRDG-BB 3015435 - Reference Information
| application | isobutyryhydrazide can be used as an intermediate in pharmaceutical synthesis. Examples of its application are as follows: 1) Preparation of 3-isopropyl -4-amino -1,2,4-triazolin-5-one, including: Step 1, in a n-butanol solvent, at a reaction temperature of 50-150°C, Isobutyric acid and hydrazine hydrate are reacted to generate isobutyryl hydrazide; Step 2, at a reaction temperature of 0-60°C, the isobutyrylhydrazide reaction liquid synthesized in step 1 is reacted with phosgene or solid light and n-butanol as a solvent to generate 2-isobutylhydrazinyl butyl formate; step 3, in an alkali solution, at a reaction temperature of 80~120 ℃, the 2-isobutylhydrazinyl butyl formate synthesized in step 2 is reacted with hydrazine hydrate to generate 3-isopropyl-4-amino-1, 2, 4-Triazolin-5-one and n-butanol. The reaction of the invention uses a single n-butanol as a solvent, the intermediate process is not separated, has a simple reaction system, the reaction speed is fast, the amount of "three wastes" is small. 2) Preparation of a new class of indole derivatives. Using indole -3-formaldehyde derivatives and isobutyryl hydrazide as raw materials, groups with anti-cancer activity such as-OCH3,-C = N-NH-C = O, etc. are introduced into the appropriate positions of indole through chemical reactions to obtain a series of indole compounds containing polyfunctional groups. The process is simple to operate, mild reaction conditions, high yield, and the compounds have good biological activity, can be used for the treatment of tumors, and has a wide range of application prospects in the field of pharmacy. |
Last Update：2024-04-09 02:00:08
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View History
CHEMBRDG-BB 3015435
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真空干燥箱
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TYRPHOSTIN AG 9