CHOLESTYRAMINE
cholestyramine resin
CAS: 11041-12-6
Molecular Formula: C27H47N
CHOLESTYRAMINE - Names and Identifiers
CHOLESTYRAMINE - Physico-chemical Properties
| Molecular Formula | C27H47N |
| Molar Mass | 385.66878 |
| Solubility | Insoluble in water, in methylene chloride and in ethanol (96 per cent). |
| Appearance | neat |
| Storage Condition | Room Temprature |
| Use | Hypolipidemic drugs, suitable for type II hyperlipidemia, atherosclerosis and other diseases |
CHOLESTYRAMINE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | FZ9310000 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 3914002000 |
CHOLESTYRAMINE - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | coleenamine, alias: cholestyramine, cholesterol-lowering sensitivity, cholestyramine; English name: Colestyramine; Molecular formula: C27H47N. Main active ingredient: chloride of polystyrene quaternary ammonium type strong basic anion exchange resin. Properties: white to white-like powder, odorless or slightly amines; hygroscopic. Insoluble in water, ethanol, chloroform or ether. Function: Used for type II hyperlipidemia, atherosclerosis, liver cirrhosis, and itching caused by cholelithiasis. The disadvantage is that 2% of patients have gastrointestinal reactions. |
| product description | coleenamine (cholestyramine) is the most important resin drug with lipid-lowering effect. The effect of this drug on lowering cholesterol and reducing the morbidity and mortality of coronary heart disease has been confirmed by long-term large-scale clinical practice. However, due to certain side effects and the lipid-lowering effect is not as good as "statins" drugs, it has been rarely used clinically in recent years. However, when combined with other types of lipid-lowering drugs, it can improve the curative effect and reduce side effects. Good clinical significance. |
| action | this product is a strong alkaline quaternary amine anion exchange resin and is the drug with the strongest cholesterol-lowering effect. After oral administration, this product combines with bile acid in the intestine, and the resulting coordination compound is not absorbed, but excreted from the body with the feces, thereby blocking the hepatic and intestinal circulation of bile acid and reducing the amount of bile acid in the liver. As a result, the cholesterol in the blood is more converted into bile acid, and the cholesterol content in the blood is reduced. At the same time, bile acid is an essential substance for the intestinal absorption of cholesterol. Cholic acid is combined with this product in the intestine to reduce the absorption of cholesterol in food and also play a role in lowering cholesterol. |
| application | Carbopol is a commonly used auxiliary material in pharmaceutical preparations. compared with coleenamine, coleenamine has a longer gastric retention time, and the drug can be evenly distributed throughout the stomach after taking it. This finding suggests that coleenamine may be developed into a mucosal drug release preparation targeting the gastric mucosa. For example, it can be combined with antibiotics to make membrane adhesion tablets for the eradication of Helicobacter pylori infection. Coleenamine is made into microcapsules that can float and release drugs in the stomach. This microcapsule can greatly extend the time of gastric retention through mucosal adsorption. This preparation is very helpful in treating gastric ulcers caused by Helicobacter pylori. Therefore, it can be expected that with the in-depth study of the subject, it is possible for colenamine to be used in pharmaceutical preparations for the treatment of gastric ulcers. |
| anion exchange resin | coleenamine, also known as cholestyramine, cholesterol-lowering sensitivity, cholestyramine, lipid-lowering resin No. 1, is a strong alkaline quaternary amine anion exchange resin, applied to low-density lipoprotein hyperlipemia, namely Ⅱa and Ⅱb hyperlipidemia, is the drug with the strongest cholesterol-lowering effect. It is not absorbed after oral administration. The chloride ions contained in the intestinal cavity are exchanged with bile acids, and they are stably combined with bile acids until they are excreted with feces, which reduces the absorption of exogenous cholesterol and hinders the absorption of bile acids into the liver and intestine. The circulation is absorbed into the blood, which reduces the amount of bile acid in the blood. As a result, it promotes the conversion of blood cholesterol to bile acid, thereby lowering cholesterol. Coleenamine has no reducing effect on triglycerides. Due to its strong cholesterol-lowering effect, this product has become the first choice for type IIa hyperlipoproteinemia. Type Ⅱb hyperlipoproteinemia should be combined with drugs that can reduce triglycerides in the blood, such as clofibrate or niacin. For type III, IV, and V hyperlipoproteinemia, cholestyramine should not be used. In addition, this product can also be used to treat atherosclerosis, liver cirrhosis, and skin itching caused by cholelithiasis. |
| Indications | Coleenamine: Mainly used to treat type Ⅱa hyperlipoproteinemia, especially familial hypercholesterolemia. It is also used to treat primary biliary cirrhosis, pruritus of cholestatic jaundice caused by drugs, hypercholesterolemia, chronic cholecystitis, gallstones, porphyrin disease, etc. treatment of atherosclerosis: 4~5g,3 times/d. Antipruritic: start 6~10g/d, maintain 3g/d, take 3 times. Long-term use can reduce the combination of bile salts in the intestine and cause fat malabsorption. Long-term use should be appropriately supplemented with fat-soluble vitamins such as vitamins A, D, K and calcium, and those who respond to the gastrointestinal tract can be appropriately added. stomach medicine. |
| adverse reactions and precautions | 1. starting taking it can cause gastrointestinal reactions such as nausea, abdominal distension, diarrhea, constipation, etc., and continuing taking it can disappear by itself. Constipation for too long should be stopped, individual patients can cause intestinal obstruction. 2. this product is dry powder and smells bad, so it needs to be mixed with flavoring agent and taken evenly. 3. Long-term large-scale administration can affect the absorption of fat and fat-soluble vitamins, so appropriate vitamin A, D, K and calcium salts should be supplemented. 4. Long-term use of coleenamine can cause folic acid deficiency, especially in children, 5mg of folic acid should be taken daily. 5. Coleenamine can be combined with cardiac glycosides, dicoumarin anticoagulants, hydrochlorothiazide, phenobarbital, thyroxine, phenylbutazone, warfarin and other drugs, and hinder the absorption of these drugs Therefore, when taking the same drugs with the above drugs, a certain interval is required. |
| use | hypolipidemic drugs are used for type ii hyperlipidemia, atherosclerosis and other diseases. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:06
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View History
CHOLESTYRAMINE
TITANIUM(IV) BIS(AMMONIUM LACTATO)DIHYDROXIDE
MANGANESE PENTACARBONYL BROMIDE
Tryptophenolide
AMINO-OXAMIDE
2-[(trimethylsilyl)oxy]propane-1,3-diyl bis(2-methylprop-2-e...
TRIISOBUTYLCHLOROSILANE
TITANIUM(IV) BIS(AMMONIUM LACTATO)DIHYDROXIDE
MANGANESE PENTACARBONYL BROMIDE
Tryptophenolide
AMINO-OXAMIDE
2-[(trimethylsilyl)oxy]propane-1,3-diyl bis(2-methylprop-2-e...
TRIISOBUTYLCHLOROSILANE