CID-2011756,5-(3-chlorophenyl)-N-(4-(MorpholinoMethyl)phenyl)furan-2-carboxaMide
5-(3-Chlorophenyl)-N-[4-morpholin-4-ymethyl)phenyl]furan-2-carboxamide
CAS: 638156-11-3
Molecular Formula: C22H21ClN2O3
CID-2011756,5-(3-chlorophenyl)-N-(4-(MorpholinoMethyl)phenyl)furan-2-carboxaMide - Names and Identifiers
CID-2011756,5-(3-chlorophenyl)-N-(4-(MorpholinoMethyl)phenyl)furan-2-carboxaMide - Physico-chemical Properties
| Molecular Formula | C22H21ClN2O3 |
| Molar Mass | 396.87 |
| Density | 1.297±0.06 g/cm3(Predicted) |
| Boling Point | 491.0±45.0 °C(Predicted) |
| Solubility | DMSO: soluble10mg/mL (clear solution) |
| Appearance | powder |
| Color | white to beige |
| pKa | 12.54±0.70(Predicted) |
| Storage Condition | room temp |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| In vitro study | CID 2011756 is an ATP-competitive PKD1 inhibitor, with an IC 50 of 3.2 µM. CID 2011756 decreases the phosphorylation of endogenous PKD1 Ser 916 in LNCaP cancer cells with an EC 50 of 10±0.7 µM. CID 2011756 also has cellular pan-PKD inhibitory effects, with IC 50 s of 0.6±0.1 µM and 0.7±0.2 µM for PKD2 and PKD3, respectively. |
CID-2011756,5-(3-chlorophenyl)-N-(4-(MorpholinoMethyl)phenyl)furan-2-carboxaMide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
CID-2011756,5-(3-chlorophenyl)-N-(4-(MorpholinoMethyl)phenyl)furan-2-carboxaMide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.52 ml | 12.599 ml | 25.197 ml |
| 5 mM | 0.504 ml | 2.52 ml | 5.039 ml |
| 10 mM | 0.252 ml | 1.26 ml | 2.52 ml |
| 5 mM | 0.05 ml | 0.252 ml | 0.504 ml |
Last Update：2024-01-02 23:10:35
CID-2011756,5-(3-chlorophenyl)-N-(4-(MorpholinoMethyl)phenyl)furan-2-carboxaMide - Reference Information
| biological activity | CID 2011756 is an inhibitor of protein kinase D (PKD), the IC50 values of PKD3 were 3.2, 0.6 and 0.7 μm, respectively. |
| Target | TargetValue PKD2 () 0.6 μm PKD3 () 0.7 μm PKD1 () 3.2 μm |
| Target | Value |
| PKD2 () | 0.6 μM |
| PKD3 () | 0.7 μM |
| PKD1 () | 3.2 μM |
| in vitro study | CID 2011756 is an ATP-competitive PKD1 inhibitor, with an IC 50 of 3.2 µm. CID 2011756 reduce the dispersion of endogenous PKD1 Ser 916 in LNCaP cancer cells with an EC 50 of 10±0.7 µm. CID 2011756 also has cellular pan-PKD inhibitory effects, with IC 50 s of 0.6±0.1 µM and 0.7±0.2 µM for PKD2 and PKD3, respectively. |
Last Update：2024-04-09 20:52:54
Supplier List
Spot supply
Product Name: 5-(3-Chlorophenyl)-N-[4-morpholin-4-ymethyl)phenyl]furan-2-carboxamide Visit Supplier Webpage Request for quotationCAS: 638156-11-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: 5-(3-Chlorophenyl)-N-[4-morpholin-4-ymethyl)phenyl]furan-2-carboxamide Visit Supplier Webpage Request for quotationCAS: 638156-11-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History