CIS-2,6-DIMETHYLMORPHOLINE

Name	Dimethylmorpholine
Synonyms	Cdmm Dimethylmorpholine Cis-2,6-Methylmorpoline cis-2,6-Dimethylmorpoline cis-2,6-Dimethylmorpholin CIS-2,6-DIMETHYLMORPHOLINE (Z)-2,6-Dimethylmorpholine cis-2,6-Dimethylmorpholine P-methoxy-alpha-Bromoacetophenone (2R,6S)-2,6-dimethylmorpholin-4-ium
CAS	6485-55-8
EINECS	229-353-0
InChI	InChI=1/C6H13NO/c1-5-3-7-4-6(2)8-5/h5-7H,3-4H2,1-2H3/p+1/t5-,6+

Molecular Formula	C6H13NO
Molar Mass	115.17
Density	0.93
Melting Point	-85 °C
Boling Point	140-142 °C
Flash Point	41 °C
Vapor Presure	3.38-5.4hPa at 15.1-21.9℃
Appearance	Liquid
Color	Clear colorless
BRN	878182
pKa	9.04±0.60(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.445-1.447

Risk Codes	R34 - Causes burns R21/22 - Harmful in contact with skin and if swallowed. R10 - Flammable R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed
Safety Description	S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S23 - Do not breathe vapour. S39 - Wear eye / face protection.
UN IDs	1993
RTECS	QE1750000
HS Code	29339900
Hazard Class	3
Packing Group	III

introduction	cis -2, 6-dimethylmorpholine is an important intermediate of antitumor drug sonigib (Sonidegib). In the prior art, a method for synthesizing cis-2, 6-dimethylmorpholine is to use diisopropanolamine in the presence of concentrated sulfuric acid at high temperature dehydration and cyclizing, and then high vacuum Fractionation of cis-trans isomers.
background	2,6-dimethylmorpholine is an important pesticide and pharmaceutical intermediate, which is indispensable in the synthesis of fungicides such as germicide, myroline, propanolene, butadiene morpholine and antifungal drug amoprofen hydrochloride. For propioline, the activity of cis isomer inhibiting bacteria is significantly higher than that of trans isomer, while the activity of cis and trans isomer mixture is lower. Usually in the field of medicine, the molecular structure of propenoline refers to the cis isomer.
application	cis -2, 6-dimethylmorpholine is an organic synthesis intermediate and a pharmaceutical intermediate, which can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes.
use	pharmaceutical intermediate, which can be used to synthesize amorofen

Last Update：2024-04-10 22:29:15

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