CORVATON
molsidomine
CAS: 25717-80-0
Molecular Formula: C9H14N4O4
CORVATON - Names and Identifiers
| Name | molsidomine |
| Synonyms | SIN-10 CORVATON corvasal Moisidomine Molsidomine molsidomine n-carboxy-3-morpholinosynonimine ethyl ester N-Carboxy-3-morpholino-syndone imine ethyl ester N-(ETHOXYCARBONYL)-3-(4-MORPHOLINO)SYDNONE IMINE N-[ETHOXYCARBONYL]-3-[4-MORPHOLINYL]SYDNONE IMINE ethoxy{[3-(morpholin-4-yl)-1,2,3-oxadiazol-3-ium-5-yl]imino}methanolate ethyl (3-morpholin-4-yl-1-oxa-2-aza-3-azoniacyclopenta-2,4-dien-5-yl)aminoformate |
| CAS | 25717-80-0 |
| EINECS | 247-207-4 |
| InChI | InChI=1/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3 |
CORVATON - Physico-chemical Properties
| Molecular Formula | C9H14N4O4 |
| Molar Mass | 242.23 |
| Density | 1.3186 (rough estimate) |
| Melting Point | 140-141°C |
| Boling Point | 385.05°C (rough estimate) |
| Solubility | Sparingly soluble in water, soluble in anhydrous ethanol and in methylene chloride. |
| Appearance | neat |
| Color | White to Off-White |
| Maximum wavelength(λmax) | 317nm(MeOH)(lit.) |
| Merck | 14,6234 |
| pKa | pK (100°) 3.0 ± 0.1 |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.6300 (estimate) |
| Physical and Chemical Properties | Colorless or white crystalline powder, odorless, gradually discoloration when exposed to light. Melting point 140-141 ℃. Soluble in chloroform, soluble in dilute hydrochloric acid, ethanol, ethyl acetate, insoluble in water, benzene, acetone, extremely insoluble in ether. |
| Use | Suitable for the treatment of angina pectoris, myocardial infarction (except acute phase), chronic coronary artery insufficiency and other diseases |
| In vivo study | Molsidomane (100,250 μg/kg) reduced coronary blood flow but did not affect coronary resistance. Molsidene reduced myocardial oxygen consumption. Heart rate and contractility are not affected by them. After treatment with molsidoman, the cardiac stroke volume and cardiac output decreased, venous return decreased due to the decrease in cardiac output, and blood pressure decreased immediately thereafter. |
CORVATON - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | WU7677400 |
| HS Code | 29349990 |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 780, 750, 1380, 1350 s.c.; 860, 800, 830, 760 i.v.; 700, 760, 1250, 1250 i.p.; 830, 840, 1050, 1200 orally (Nakaguchi) |
CORVATON - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.128 ml | 20.642 ml | 41.283 ml |
| 5 mM | 0.826 ml | 4.128 ml | 8.257 ml |
| 10 mM | 0.413 ml | 2.064 ml | 4.128 ml |
| 5 mM | 0.083 ml | 0.413 ml | 0.826 ml |
Last Update：2024-01-02 23:10:35
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