CP673451

Name	CP 673451
Synonyms	CP673451 CP 673451 CP-673451 1-[2-[5-(2-Methoxyethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-ylamine 4-PiperidinaMine,1-[2-[5-(2-Methoxyethoxy)-1H-benziMidazol-1-yl]-8-quinolinyl]- 1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine 1-(2-(5-(2-methoxyethoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine 1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamineCP 673451 1-[2-[5-(2-Methoxyethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-ylamine CP 673451
CAS	343787-29-1

Molecular Formula	C24H27N5O2
Molar Mass	417.5
Density	1.32
Boling Point	656.3±65.0 °C(Predicted)
pKa	9.84±0.20(Predicted)
Storage Condition	-20℃
In vitro study	CP-673451 is a selective PDGFR α/β inhibitor with an IC50 value of 10 nM/1 nM, which is more than 450 times more selective than other angiogenic receptors. In malignant glial tumors, CP-673451 (33 mg/kg) was able to inhibit> 50% of the PDGFR-β receptor for 4 H, with a corresponding EC50 of 120 ng/mL at C max in plasma. In the angiogenesis model of sponges, CP-673451 at 3 mg/kg (q.d. × 5, p.o., at a dose of 5.5 ng/mL at C max), 70% PDGF-BB-stimulated angiogenesis was inhibited. CP-673451 reduces cell proliferation by reducing phosphorylation of GSK-3α and GSK-3β. In RD and RUCH2 medium, CP-673451 interferes with rhabdosphere formation ability and cell differentiation, resulting in increased senescence.
In vivo study	CP 673451 (once daily oral dosing) inhibits a number of human transplanted tumors in athymic mice, including H460 human lung carcinoma, Colo205 and LS174T human colon carcinoma, and U87MG human glioblastoma, in its subcutaneous growth (ED50 < 33 mg/kg). In RUCH2 xenografted mice, CP 673451 reduced tumor growth and stromal cell infiltration.

Last Update：2024-01-02 23:10:35

Product Name: CP-673451 Visit Supplier Webpage Request for quotation
CAS: 343787-29-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: CP-673451 Visit Supplier Webpage Request for quotation
CAS: 343787-29-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

CP673451

CP673451 Request for Quotation