CPI-455

CPI-455 - Names and Identifiers

Name	CPI-455； 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
Synonyms	CPI455 CPI-455 CPI 455 CPI-455(free base) 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl- CPI-455； 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
CAS	1628208-23-0

CPI-455 - Physico-chemical Properties

Molecular Formula	C16H14N4O
Molar Mass	278.31
Density	1.28±0.1 g/cm3(Predicted)
Boling Point	488.7±55.0 °C(Predicted)
Solubility	Soluble in DMSO
Appearance	solid
Color	Off-white
pKa	-5.10±0.60(Predicted)
Storage Condition	-20°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Use	CPI-455 is a specific pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A, CPI-455 mediates KDM5 inhibition, improves the overall level of H3K4me3, and reduces the number of drug-resistant persistent cancer cells in a multi-tumor cell line model.

CPI-455 - Reference

Reference

1: Vinogradova M, Gehling VS, Gustafson A, Arora S, Tindell CA, Wilson C, Williamson KE, Guler GD, Gangurde P, Manieri W, Busby J, Flynn EM, Lan F, Kim HJ, Odate S, Cochran AG, Liu Y, Wongchenko M, Yang Y, Cheung TK, Maile TM, Lau T, Costa M, Hegde GV, Jackson E, Pitti R, Arnott D, Bailey C, Bellon S, Cummings RT, Albrecht BK, Harmange JC, Kiefer JR, Trojer P, Classon M. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol. 2016 Jul;12(7):531-8. doi: 10.1038/nchembio.2085. PubMed PMID: 27214401.