CROMOSIL
adrenochrome semicarbazone
CAS: 69-81-8
Molecular Formula: C10H12N4O3
CROMOSIL - Names and Identifiers
| Name | adrenochrome semicarbazone |
| Synonyms | CROMOSIL ADRENOXYL CROMADRENAL Carbazochrome CARBAZOCHROME ADENOCHROME SEMICARBAZONE adrenochrome semicarbazone adrenochrome monosemicarbazone 3-HYDROXY-1-METHYL-5,6-INDOLINEDIONE SEMICARBAZONE 3-HYDROXY-1-METHYL-5,6-INDOLINEDION 5-SEMICARBAZONE 3-hydroxy-1-methyl-5,6-indolinedione 5-semicarbazone 3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione 5-semicarbazone (5Z)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione 5-semicarbazone |
| CAS | 69-81-8 |
| EINECS | 200-717-0 |
| InChI | InChI=1/C10H12N4O3/c1-14-4-9(16)5-2-6(12-13-10(11)17)8(15)3-7(5)14/h2-3,9,16H,4H2,1H3,(H3,11,13,17) |
CROMOSIL - Physico-chemical Properties
| Molecular Formula | C10H12N4O3 |
| Molar Mass | 236.23 |
| Density | 1.63±0.1 g/cm3(Predicted) |
| Melting Point | 203° (dec) |
| Solubility | DMSO (Slightly), Water (Slightly, Heated) |
| Appearance | Solid |
| Color | Dark Orange to Very Dark Orange |
| Merck | 14,172 |
| pKa | 12.38±0.40(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Hygroscopic |
| Refractive Index | 1.732 |
| MDL | MFCD00059705 |
| Physical and Chemical Properties | Orange-red crystal or crystalline powder. The melting point is not lower than 220 °c (decomposition). Slightly soluble in water, ethanol, insoluble in ether, chloroform. Its sodium salicylate ([1305- 01-9]) is orange powder, melting point 196- 197.5 ℃ (decomposition), solubility in water at 25 ℃ 0.61 mg/mL, insoluble in ether, chloroform, the pH of the 10% aqueous solution is 6.7-7.3. |
| Use | Haemostatic medicine, used for persistent Ziban syndrome, hereditary telangiectasia and prevention of lung, kidney, intestine, brain, uterus and other bleeding |
CROMOSIL - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | NM1925500 |
| HS Code | 29339900 |
CROMOSIL - Reference Information
| Clinical application | carbamol, also known as anluoxue, is one of the commonly used hemostatic drugs in clinic, which is mainly used for retinal hemostasis. Nasal wound hemostasis, can also be combined with gelatin made hemostatic cotton for local hemostasis. Its mechanism of action is to increase the resistance of capillaries to injury, reduce the fragility of capillaries, so as to achieve the purpose of hemostasis. |
| pharmacological action | The carbamol is sodium salicylate, which is the oxidation product of adrenalin, and has no adrenergic effect, therefore, it does not affect blood pressure and heart rate, but can enhance the resistance of capillaries to injury, stabilize the acidic mucopolysaccharides in blood vessels and surrounding tissues, reduce the permeability of capillaries, and enhance the contractile effect of damaged capillary ends, thereby shortening the hemostasis time. In addition, the drug can also inhibit the synthesis and release of prostaglandin E(PCE), thereby reducing capillary permeability and preventing the exudation of pyrogenic substances. |
| indications | carbamod is mainly used for bleeding caused by increased capillary permeability, such as idiopathic purpura, retinal hemorrhage, chronic pulmonary hemorrhage, gastrointestinal bleeding, epistaxis, Massive hemoptysis, blood. Urine, bleeding hemorrhoids, uterine bleeding l, cerebral hemorrhage. |
| precautions | 1. 2. The drug can not be used for intravenous injection. 3. The curative effect on massive hemorrhage and Arterial hemorrhage is poor. |
| adverse reaction | carbamod has low toxicity, and can produce salicylic acid-like reaction (because it contains sodium salicylate) in a large number of applications, such as Nausea, Vomit, dizziness, tinnitus, vision loss, can also cause Mental Disorder and abnormal EEG activity. |
| drug interaction | 1. Antihistamines and Anticholinergics can affect the hemostasis of this drug. The effect should be avoided. This drug can reduce the effect of antipsychotic drugs such as haloperidol, and the combination of the two drugs can worsen psychosis. 3. The drug can reduce the anti-epileptic drug |
| Use | hemostatic. It is used to prevent pulmonary, renal, intestinal, cerebral and uterine bleeding and hereditary telangiectasia. This product can reduce the permeability of capillaries, promote the retraction of damaged capillary end and stop bleeding. It is mainly used for bleeding caused by increased capillary permeability, such as idiopathic purpura, retinal hemorrhage, chronic pulmonary hemorrhage, gastrointestinal bleeding, epistaxis, hemoptysis, hematuria, hemorrhoid bleeding, uterine bleeding, cerebral hemorrhage, etc. The effect on massive hemorrhage and Arterial hemorrhage is poor. Haemostatic medicine, for persistent purple syndrome, hereditary telangiectasia and prevent lung, kidney, intestine, brain, uterus and other bleeding. |
| production method | adrenaline hydrochloride is obtained by oxidation, cyclization, and condensation. |
Last Update：2024-04-10 22:41:30
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