Name | BAMB-4 |
Synonyms | BAMB4 BAMB-4 BAMB 4 CS-1193 ITPKA-IN-C14 BAMB-4(ITPKA-IN-C14) Benzamide, N-1,2-benzisoxazol-3-yl-4-methyl- |
CAS | 891025-25-5 |
Molecular Formula | C15H12N2O2 |
Molar Mass | 252.27 |
Density | 1.295±0.06 g/cm3(Predicted) |
Boling Point | 360.3±25.0 °C(Predicted) |
Solubility | DMSO : ≥ 40 mg/mL (158.56 mM) |
pKa | 10.94±0.43(Predicted) |
Storage Condition | 2-8°C |
Use | BAMB-4(ITPKA-IN-C14) is a new membrane permeable ITPKA inhibitor with IC50 of 37uM in ADP-Glo experiments. |
Reference Show more | 1: Schröder D, Tödter K, Gonzalez B, Franco-Echevarría E, Rohaly G, Blecher C, Lin HY, Mayr GW, Windhorst S. The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells. Biochem Pharmacol. 2015 Jul 15;96(2):143-50. doi: 10.1016/j.bcp.2015.05.004. Epub 2015 May 15. PubMed PMID: 25986882. 2: Schröder D, Rehbach C, Seyffarth C, Neuenschwander M, Kries JV, Windhorst S. Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A. Biochem Biophys Res Commun. 2013 Sep 20;439(2):228-34. doi: 10.1016/j.bbrc.2013.08.053. Epub 2013 Aug 24. PubMed PMID: 23981806. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.964 ml | 19.82 ml | 39.64 ml |
5 mM | 0.793 ml | 3.964 ml | 7.928 ml |
10 mM | 0.396 ml | 1.982 ml | 3.964 ml |
5 mM | 0.079 ml | 0.396 ml | 0.793 ml |
biological activity | BAMB-4(ITPKA-IN-C14) is a novel membrane permeable ITPKA inhibitor with an IC50 of 37uM in the ADP-Glo experiment. |