CS-1242
SAR245409
CAS: 934493-76-2
Molecular Formula: C13H14N6O
CS-1242 - Names and Identifiers
CS-1242 - Physico-chemical Properties
| Molecular Formula | C13H14N6O |
| Molar Mass | 270.29 |
| Density | 1.397±0.06 g/cm3(Predicted) |
| Boling Point | 605.0±65.0 °C(Predicted) |
| Solubility | DMSO: 16 mg/mL |
| pKa | 12.54±0.10(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | XL765 was the first oral dual inhibitor of PI3K and mTOR, with IC50 values of 39, 113, 9, 43, and -150 nM for p110α, β, γ, δ, and mTOR, respectively. In vitro, XL765 reduced cell viability in a concentration-dependent manner. |
| In vivo study | Oral feeding of XL765 resulted in a 12-fold decrease in metaphase tumors compared to the control group. XL765 showed activity either alone or in combination with other drugs in various GBM xenografts. XL765 acts on in vitro cultured human xenografts, resulting in down-regulation of the downstream phosphorylated proteins of PI3K: pAkt and pPRAS40, and the downstream phosphorylated proteins of mTOR: pS6 and p4EBP1. |
CS-1242 - Risk and Safety
| HS Code | 29337900 |
CS-1242 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.7 ml | 18.499 ml | 36.997 ml |
| 5 mM | 0.74 ml | 3.7 ml | 7.399 ml |
| 10 mM | 0.37 ml | 1.85 ml | 3.7 ml |
| 5 mM | 0.074 ml | 0.37 ml | 0.74 ml |
Last Update：2024-01-02 23:10:35
Supplier List
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Product Name: Voxtalisib (XL765, SAR245409) Visit Supplier Webpage Request for quotationCAS: 934493-76-2
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Product Name: SAR245409 Visit Supplier Webpage Request for quotationCAS: 934493-76-2
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Product Name: SAR245409 Visit Supplier Webpage Request for quotation
CAS: 934493-76-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 934493-76-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Voxtalisib (XL765, SAR245409) Visit Supplier Webpage Request for quotationCAS: 934493-76-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: XL765; SAR245409 Visit Supplier Webpage Request for quotationCAS: 934493-76-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SAR245409 Visit Supplier Webpage Request for quotationCAS: 934493-76-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: SAR245409 Visit Supplier Webpage Request for quotation
CAS: 934493-76-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 934493-76-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
CS-1242
三甲基乙烯基铵 (溴化物)
2-Methoxypyridine-5-boronic Acid (contains varying aMounts of Anhydride)
ETHYL 2-AMINO-5-OXAZOLECARBOXYLATE
2-巯基苯甲酰胺
3-硝基苯叉基乙酰乙酸乙脂
DIETHYLENE GLYCOL DIMETHYL ETHER
三甲基乙烯基铵 (溴化物)
2-Methoxypyridine-5-boronic Acid (contains varying aMounts of Anhydride)
ETHYL 2-AMINO-5-OXAZOLECARBOXYLATE
2-巯基苯甲酰胺
3-硝基苯叉基乙酰乙酸乙脂
DIETHYLENE GLYCOL DIMETHYL ETHER