CS-1285

Name	4SC-202 (free base)
Synonyms	CS-1285 Domatinostat domatinostat HCl 4SC-202 (free base) Domatinostat (4SC202) (E)-N-(2-aminophenyl)-3-(1-(4-(1-methyl-1H-pyrazol-4-yl)phenylsulfonyl)-1H-pyrrol-3-yl)acrylamide (2E)-N-(2-Aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-2-propenamide 2-Propenamide, N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-, (2E)-
CAS	910462-43-0

Molecular Formula	C23H21N5O3S
Molar Mass	447.51
Density	1.34±0.1 g/cm3(Predicted)
Solubility	DMSO: ≥ 58 mg/mL
pKa	12.60±0.70(Predicted)
Storage Condition	-20℃
In vitro study	In HeLa cells, 4SC-202 induced hyperacetylation of histone H3 with an EC50 of 1.1 μm. 4SC-202 induces G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causes spindle collapse and multiple nucleation centers. In addition, 4SC-202 exhibited broad-spectrum anti-tumor activity against human cancer cell lines with an IC50 of 0.7 μm.
In vivo study	In Vivo, 4SC-202 has high oral bioavailability and exhibits high metabolic stability and low plasma clearance. In the A549 NSCLC xenograft and RKO27 colon cancer models, 4SC-202 (120 mg/kg p.o.) showed significant potent antitumor activity.

Last Update：2024-01-02 23:10:35

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Product Name: 4SC-202 (free base) Visit Supplier Webpage Request for quotation
CAS: 910462-43-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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CS-1285

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