CS-1469
Ro 5126766
CAS: 946128-88-7
Molecular Formula: C21H18FN5O5S
CS-1469 - Names and Identifiers
| Name | Ro 5126766 |
| Synonyms | CS-1469 CH5126766 Ro 5126766 RO5126766(CH5126766) 3-{2-(methylaminosulfonyl)amino-3-fluoropyridin-4-ylmethyl}-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran Sulfamide, N-[3-fluoro-4-[[4-methyl-2-oxo-7-(2-pyrimidinyloxy)-2H-1-benzopyran-3-yl]methyl]-2-pyridinyl]-N'-methyl- 3-[[2-[(Methylaminosulfonyl)amino]-3-fluoropyridin-4-yl]methyl]-4-methyl-7-[(pyrimidin-2-yl)oxy]-2H-1-benzopyran-2-one RO5126766(CH5126766) 3-[[2-[(Methylaminosulfonyl)amino]-3-fluoropyridin-4-yl]methyl]-4-methyl-7-[(pyrimidin-2-yl)oxy]-2H-1-benzopyran-2-one |
| CAS | 946128-88-7 |
CS-1469 - Physico-chemical Properties
| Molecular Formula | C21H18FN5O5S |
| Molar Mass | 471.46 |
| Density | 1.495±0.06 g/cm3(Predicted) |
| Boling Point | 690.8±65.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 6.60±0.50(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | In HCT116 KRAS-mutant colorectal cancer cells, CH5126766 significantly reduced the levels of phospho-MEK and phospho-ERK. CH5126766 inhibits RAF kinase by binding to MEK1 and makes MEK a dominant negative inhibitor of RAF. In Raf or RAS-mutant cell lines SK-MEL-28,SK-MEL-2,MIAPaCa-2,SW480,HCT116, and PC3 cells, CH5126766 inhibited cell growth with IC50 of 65,28,40,46, and 277 nM. In two melanoma cell lines containing either BRAF V600E or NRAS mutations, RO5126766 induced G1 cell cycle arrest with CDK inhibitor p27 upregulation and cyclin D1 downregulation. |
| In vivo study | In the HCT116 (G13D KRAS) mouse xenograft model, CH5126766 (25 mg/kg, p.o.) inhibition of ERK signaling output is more potent than standard MEK inhibitors, which induce MEK phosphorylation, and have potent anti-tumor activity. In HCT116 (K-ras) and COLO205 (B-raf) mutant xenografts, CH5126766 (0.3 mg/kg) caused a significant reduction in [18 μF] FDG uptake. RO5126766 also inhibited tumor growth in a SK-MEL-2 xenograft model. |
CS-1469 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.121 ml | 10.605 ml | 21.211 ml |
| 5 mM | 0.424 ml | 2.121 ml | 4.242 ml |
| 10 mM | 0.212 ml | 1.061 ml | 2.121 ml |
| 5 mM | 0.042 ml | 0.212 ml | 0.424 ml |
Last Update：2024-01-02 23:10:35
CS-1469 - Introduction
PD 5126766 is a compound with the chemical name 2-(4-amino-7-chloroquinolin-1-yl) acetic acid. It is a new type of alkaloid compound with unique chemical structure and biological activity.
The main use of Ro 5126766 is as an anti-cancer drug, which is a kind of kinase inhibitor. It inhibits the growth and spread of tumor cells by inhibiting the key signaling pathways of tumorigenesis, thus having anti-tumor activity.
The method of preparing PD 5126766 is generally by chemical synthesis. Specifically, 7-chloroquinoline-1-carboxylic acid is first synthesized and then reacted with 4-aminoacetic acid to give PD 5126766.
Regarding safety information, Ro 5126766 need to follow relevant safety procedures during use and storage. It may have certain toxic and irritating effects on the human body, so protective measures should be paid attention. Wear appropriate protective equipment during use to avoid inhalation, contact with skin and eyes. At the same time, it needs to be stored properly to avoid reaction with other chemicals or being affected by heat sources, fire sources, etc.
The main use of Ro 5126766 is as an anti-cancer drug, which is a kind of kinase inhibitor. It inhibits the growth and spread of tumor cells by inhibiting the key signaling pathways of tumorigenesis, thus having anti-tumor activity.
The method of preparing PD 5126766 is generally by chemical synthesis. Specifically, 7-chloroquinoline-1-carboxylic acid is first synthesized and then reacted with 4-aminoacetic acid to give PD 5126766.
Regarding safety information, Ro 5126766 need to follow relevant safety procedures during use and storage. It may have certain toxic and irritating effects on the human body, so protective measures should be paid attention. Wear appropriate protective equipment during use to avoid inhalation, contact with skin and eyes. At the same time, it needs to be stored properly to avoid reaction with other chemicals or being affected by heat sources, fire sources, etc.
Last Update：2024-04-09 21:11:58
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CAS: 946128-88-7
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Product Name: Ro 5126766 Visit Supplier Webpage Request for quotation
CAS: 946128-88-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 946128-88-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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