CS-1734
PF-06447475
CAS: 1527473-33-1
Molecular Formula: C17H15N5O
CS-1734 - Names and Identifiers
CS-1734 - Physico-chemical Properties
| Molecular Formula | C17H15N5O |
| Molar Mass | 305.33 |
| Density | 1.40±0.1 g/cm3(Predicted) |
| Melting Point | >223°C (dec.) |
| Solubility | DMSO: ≥ 33 mg/mL |
| Appearance | powder |
| Color | white to beige |
| pKa | 12.96±0.50(Predicted) |
| Storage Condition | room temp |
| In vitro study | In macrophage Raw264.7, PF-06447475 inhibited its endogenous LRRK2 kinase activity with an IC50 of less than 10 nM. In astrocytes, PF-06447475 were able to rescue defects in lysosomal morphology and function due to LRRK2 mutations. |
| In vivo study | In G2019S-LRRK2 transgenic mice (G2019S BAC-transgenic mice),PF-06447475 (100 mg/kg, p.o.) it can inhibit the phosphorylation of LRRK2 S935 and S1292 with IC50 of 103 nM and 21 nM, respectively. In G2019S-LRRK2 rats, PF-06447475 (30 mg/kg, p.o.) prevented α-synuclein-induced dopaminergic neurodegeneration and reduced neuroinflammation associated with G2019S-LRRK2 expression. |
CS-1734 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
CS-1734 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.275 ml | 16.376 ml | 32.751 ml |
| 5 mM | 0.655 ml | 3.275 ml | 6.55 ml |
| 10 mM | 0.328 ml | 1.638 ml | 3.275 ml |
| 5 mM | 0.066 ml | 0.328 ml | 0.655 ml |
Last Update：2024-01-02 23:10:35
CS-1734 - Reference Information
| biological activity | PF-06447475 is an effective, selective LRRK2 kinase inhibitor that can penetrate into the brain, IC50 is 3 nM. |
| target | TargetValue LRRK2 (Cell-free assay) 3nM G2019S LRRK2 (Cell-free assay) 11nM |
| Target | Value |
| LRRK2 (Cell-free assay) | 3nM |
| G2019S LRRK2 (Cell-free assay) | 11nM |
| in vitro study | in macrophage Raw264.7, PF-06447475 inhibited its endogenous LRRK2 kinase activity with IC50 less than 10 nM. In astrocytes, PF-06447475 can save lysosomal morphological and functional defects caused by LRRK2 mutation. |
| in vivo study | in G2019S-LRRK2 transgenic mice (G2019S BAC-transgenic mice),PF-06447475 (100 mg/kg, p.o.) can inhibit phosphorylation of LRRK2 S935 and S1292 with IC50 of 103 nM and 21 nM respectively. In G2019S-LRRK2 rats, PF-06447475 (30 mg/kg, p.o.) can prevent α-synuclein-induced dopaminergic neurodegeneration and reduce neuroinflammation related to G2019S-LRRK2 expression. |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: PF-06447475 Visit Supplier Webpage Request for quotationCAS: 1527473-33-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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