CS-1751
Remodelin (hydrobromide)
CAS: 1622921-15-6
Molecular Formula: C15H15BrN4S
CS-1751 - Names and Identifiers
CS-1751 - Physico-chemical Properties
| Molecular Formula | C15H15BrN4S |
| Molar Mass | 363.2754 |
| Solubility | DMSO : ≥ 44 mg/mL (121.12 mM)H2O : < 0.1 mg/mL (insoluble) |
| Storage Condition | -20℃ |
| Use | Remodelin hydrobromide is a new potent selective inhibitor of acetyltransferase NAT10. Remodelin is a cell-permeable, potent, and stable analog of CPTH2. Remodelin inhibits acetyl-transferase NAT10, a nucleolar N-acetyltransferase involved in stabilization of microtubules. Remodelin is a cell-permeable, potent, and stable analog of CPTH2. Remodelin was found to correct cell defects associated with progeria, restoring and improving nuclear shape and reducing the DNA damage believed to be associated with mutations in the gene for laminin A. |
| In vitro study | Remodelin, by inhibiting NAT10, mediates microtubule recombination to remedy the nuclear shape of LMNA-depleted cells and to improve the nuclear shape and health of HGPS cells. Remodelin may therefore provide therapeutic potential for alleviating malnutrition and premature aging diseases. Remodelin, by inhibiting NAT10, mediates microtubule recombination to remedy the nuclear shape of LMNA-depleted cells and improves the nuclear shape and health of HGPS cells. Remodelin may therefore provide therapeutic potential for alleviating malnutrition and premature aging diseases. |
CS-1751 - Reference
| Reference Show more | 1: de Carlo TE, Chin AT, Bonini Filho MA, Adhi M, Branchini L, Salz DA, Baumal CR, Crawford C, Reichel E, Witkin AJ, Duker JS, Waheed NK. DETECTION OF MICROVASCULAR CHANGES IN EYES OF PATIENTS WITH DIABETES BUT NOT CLINICAL DIABETIC RETINOPATHY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. Retina. 2015 Oct 14. [Epub ahead of print] PubMed PMID: 26469537. 2: Lacruz RS, Bromage TG, O'Higgins P, Toro-Ibacache V, Warshaw J, Berger LR. Distinct growth of the nasomaxillary complex in Au. sediba. Sci Rep. 2015 Oct 15;5:15175. doi: 10.1038/srep15175. PubMed PMID: 26469387. 3: Ock S, Lee WS, Ahn J, Kim HM, Kang H, Kim HS, Jo D, Abel ED, Lee TJ, Kim J. Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice. Endocrinology. 2015 Oct 15:en20151709. [Epub ahead of print] PubMed PMID: 26469138. 4: Meï C, Michaud M, Cussac M, Albrieux C, Gros V, Maréchal E, Block MA, Jouhet J, Rébeillé F. Levels of polyunsaturated fatty acids correlate with growth rate in plant cell cultures. Sci Rep. 2015 Oct 15;5:15207. doi: 10.1038/srep15207. PubMed PMID: 26469123. 5: Kim SY, Sim CK, Tang H, Han W, Zhang K, Xu F. Acetylome Analysis Identifies SIRT1 Targets in mRNA-Processing and Chromatin-Remodeling in Mouse Liver. PLoS One. 2015 Oct 15;10(10):e0140619. doi: 10.1371/journal.pone.0140619. eCollection 2015. PubMed PMID: 26468954. |
CS-1751 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.753 ml | 13.764 ml | 27.527 ml |
| 5 mM | 0.551 ml | 2.753 ml | 5.505 ml |
| 10 mM | 0.275 ml | 1.376 ml | 2.753 ml |
| 5 mM | 0.055 ml | 0.275 ml | 0.551 ml |
Last Update：2024-01-02 23:10:35
CS-1751 - Introduction
Remodelin (hydrobromide) is a compound whose chemical name is hydrobrominated Remodelin. The following is a description of the nature, use, formulation and safety information of Remodelin (hydrobromide):
Properties: Remodelin (hydrobroromide) is a white crystalline powder, soluble in water and organic solvents. It is a compound that inhibits enzyme activity and can be used to inhibit the function of certain enzymes.
Uses: Remodelin (hydrobromide) has anti-tumor activity and can be used for cancer treatment research. It can also be applied in genetic studies to explore the mechanisms involved in cell reprogramming and tissue regeneration.
Preparation method: The preparation method of Remodelin (hydrobromide) is relatively complicated, and generally requires a chemical synthesis reaction. Specific methods of preparation can be found in the relevant scientific literature or consulted with experts in the field of medicinal chemistry.
Safety Information: Remodelin (hydrobromide) is generally relatively safe when used and stored correctly. However, as a pharmaceutical compound, it is recommended to use and handle under professional guidance. Safety practices should be followed during use and appropriate personal protective equipment should be used. In case of accidental ingestion or contact with skin or eyes, please seek medical advice and bring the safety data sheet of the relevant substance. When using Remodelin (hydrobromide), care should also be taken to avoid incompatible reactions with other chemicals and to ensure proper handling and disposal of waste.
Properties: Remodelin (hydrobroromide) is a white crystalline powder, soluble in water and organic solvents. It is a compound that inhibits enzyme activity and can be used to inhibit the function of certain enzymes.
Uses: Remodelin (hydrobromide) has anti-tumor activity and can be used for cancer treatment research. It can also be applied in genetic studies to explore the mechanisms involved in cell reprogramming and tissue regeneration.
Preparation method: The preparation method of Remodelin (hydrobromide) is relatively complicated, and generally requires a chemical synthesis reaction. Specific methods of preparation can be found in the relevant scientific literature or consulted with experts in the field of medicinal chemistry.
Safety Information: Remodelin (hydrobromide) is generally relatively safe when used and stored correctly. However, as a pharmaceutical compound, it is recommended to use and handle under professional guidance. Safety practices should be followed during use and appropriate personal protective equipment should be used. In case of accidental ingestion or contact with skin or eyes, please seek medical advice and bring the safety data sheet of the relevant substance. When using Remodelin (hydrobromide), care should also be taken to avoid incompatible reactions with other chemicals and to ensure proper handling and disposal of waste.
Last Update：2024-04-09 01:59:57
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Spot supply
Product Name: Remodelin (hydrobromide) Visit Supplier Webpage Request for quotationCAS: 1622921-15-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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